CGP 25454A
- CAS No.
- 104391-26-6
- Chemical Name:
- CGP 25454A
- Synonyms
- CGP 25454A;CGP25454A;CGP 25454A
- CBNumber:
- CB43134115
- Molecular Formula:
- C15H21Cl2N3O2
- Molecular Weight:
- 346.25
- MDL Number:
- MOL File:
- 104391-26-6.mol
CGP 25454A price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-5748 | CGP25454A 99.46% | 104391-26-6 | 10mg | $480 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611435 | CGP-25454A | 104391-26-6 | 5mg | $569.5 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611435 | CGP-25454A | 104391-26-6 | 10mg | $734.4 | 2021-12-16 | Buy |
| ChemScene | CS-5748 | CGP25454A 99.46% | 104391-26-6 | 50mg | $960 | 2021-12-16 | Buy |
| ChemScene | CS-5748 | CGP25454A 99.46% | 104391-26-6 | 5mg | $280 | 2021-12-16 | Buy |
CGP 25454A Chemical Properties,Uses,Production
Biological Activity
CGP 25454A is a novel and selective presynaptic dopamine autoreceptor antagonist.
in vitro
CGP 25454A increase the field-stimulated [3H]- and [14C]-overflow from rat striatal slices preloaded with [3H]dopamine and [14C]choline, indicating that CGP 25454A is able to enhance the release of both dopamine (DA) and acetylcholine (ACh). However, CGP 25454A is 12.9 times more potent in increasing, by 1/6 of the apparent maximal increase, the release of [3H]DA than that of [14C]ACh.
in vivo
CGP 25454A increase [3H]spiperone binding to receptors of the D2 family in rat striatum by 90-110% (ED50: 13 mg/kg i.p.). As a similar increase in [3H]spiperone binding is found with a variety of agents which increase the synaptic concentration of endogenous DA, the effect of CGP 25454A most probably reflects an enhanced release of DA under in vivo conditions. At 30-100 mg/kg, CGP 25454A inhibit [3H]spiperone binding in the pituitary of the same animals as a result of a blockade of postsynaptic DA receptors.
CGP 25454A Preparation Products And Raw materials
Raw materials
Preparation Products
CGP 25454A Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7553 | 61 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | chenjw@absin.cn | China | 24734 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 29778 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |