ChemicalBook >> CAS DataBase List >>Fezolinetant
Fezolinetant
- CAS No.
- 1629229-37-3
- Chemical Name:
- Fezolinetant
- Synonyms
- ESN-364;Fezolinetant;Fexolinetant;FEZOLINETANT; ESN-364; ESN 364; ESN364;Inhibitor,Neurokinin Receptor,ESN364,Tachykinin receptor,ESN 364,Fezolinetant,inhibit,NK receptor;(R)-(4-fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone;Methanone, [(8R)-5,6-dihydro-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl](4-fluorophenyl)-
- CBNumber:
- CB43159873
- Molecular Formula:
- C16H15FN6OS
- Molecular Weight:
- 358.39
- MDL Number:
- MFCD30532641
- MOL File:
- 1629229-37-3.mol
Last updated:2024-08-13 13:49:30
| Boiling point | 623.0±65.0 °C(Predicted) |
|---|---|
| Density | 1.56±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO:20.0(Max Conc. mg/mL);55.8(Max Conc. mM) |
| pka | -0.28±0.40(Predicted) |
| form | Solid |
| color | White to yellow |
| InChI | InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1 |
| InChIKey | PPSNFPASKFYPMN-SECBINFHSA-N |
| SMILES | C(N1CCN2C(C3SN=C(C)N=3)=NN=C2[C@H]1C)(C1=CC=C(F)C=C1)=O |
| FDA UNII | 83VNE45KXX |
Fezolinetant price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-7952 | Fezolinetant 98.16% | 1629229-37-3 | 1mg | $120 | 2021-12-16 | Buy |
| ChemScene | CS-7952 | Fezolinetant 98.16% | 1629229-37-3 | 5mg | $390 | 2021-12-16 | Buy |
| ChemScene | CS-7952 | Fezolinetant 98.16% | 1629229-37-3 | 10mg | $570 | 2021-12-16 | Buy |
| ChemScene | CS-7952 | Fezolinetant 98.16% | 1629229-37-3 | 25mg | $1140 | 2021-12-16 | Buy |
| ChemScene | CS-7952 | Fezolinetant 98.16% | 1629229-37-3 | 50mg | $1740 | 2021-12-16 | Buy |
Fezolinetant Chemical Properties,Uses,Production
Uses
Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.
Definition
ChEBI: Fezolinetant is a triazolopyrazine that is 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine substituted by 3-methyl-1,2,4-thiadiazol-5-yl, 4-fluorobenzoyl and methyl groups at positions 3, 7, and 8R, respectively. It is a prescription medicine used to reduce moderate to severe vasomotor symptoms due to menopause. It has a role as a neurokinin-3 receptor antagonist. It is a member of monofluorobenzenes, a triazolopyrazine, a member of thiadiazoles, a member of benzamides and a tertiary carboxamide.
Mechanism of action
Fezolinetant is an oral non-hormonal therapy that is an NK3R antagonist. It works by binding to and blocking the activity of NK3 receptors, which play a role in the regulation of body temperature in the brain.
Side effects
The common side effects of Fezolinetant include abdominal pain, diarrhoea, insomnia, back pain, hot flushes and elevated liver transaminases.
Fezolinetant Preparation Products And Raw materials
Raw materials
Preparation Products
Fezolinetant Suppliers
Global( 88)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd. | +86-0311-67591193 +8613931880626 | sales02@dingminpharma.com | China | 242 | 58 |
| S&Y Biochem Co.,Ltd | +8617774091612 | marketing@sybiochem.com | China | 94 | 58 |
| Jinan Million Pharmaceutical Co., Ltd | 0531-68659554 +8613031714605 | info@millionpharm.com | China | 197 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 7621 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 13185 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| Chemtour Biotech Co., Ltd | +8617327281506 | market@chemtour.com | China | 1460 | 58 |
View Lastest Price from Fezolinetant manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-23 | Birinapant
1629229-37-3
|
US $1.00-0.50 / kg | 1kg | 99% | 200 | Jinan Million Pharmaceutical Co., Ltd | |
 |
2024-08-22 | Fezolinetant
1629229-37-3
|
US $10.00 / kg | 1kg | 99 | 100 | S&Y Biochem Co.,Ltd | |
 |
2024-08-20 | Fezolinetant
1629229-37-3
|
US $0.00 / g | 1g | More Than 99% | 50kg/Month | BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. |
-
- Birinapant
1629229-37-3
- US $1.00-0.50 / kg
- 99%
- Jinan Million Pharmaceutical Co., Ltd
-
- Fezolinetant
1629229-37-3
- US $10.00 / kg
- 99
- S&Y Biochem Co.,Ltd
-
- Fezolinetant
1629229-37-3
- US $0.00 / g
- More Than 99%
- BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
ESN-364
FEZOLINETANT; ESN-364; ESN 364; ESN364
Methanone, [(8R)-5,6-dihydro-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl](4-fluorophenyl)-
Inhibitor,Neurokinin Receptor,ESN364,Tachykinin receptor,ESN 364,Fezolinetant,inhibit,NK receptor
(R)-(4-fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone
Fexolinetant
Fezolinetant
1629229-37-3
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