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IWP-051
- CAS No.
- 1354041-91-0
- Chemical Name:
- IWP-051
- Synonyms
- IWP-051;4(3H)-Pyrimidinone, 5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1H-pyrazol-3-yl]-
- CBNumber:
- CB43304417
- Molecular Formula:
- C17H11F2N5O2
- Molecular Weight:
- 355.3
- MDL Number:
- MOL File:
- 1354041-91-0.mol
Last updated:2023-03-31 09:12:59
IWP-051 Chemical Properties,Uses,Production
Description
IWP-051 is a potent, orally active sGC stimulator (EC50 = 290nM). IWP-051 showed >99% plasma protein binding, high metabolic stability, high permeability, and no efflux in a Caco-2 model of intestinal absorption. IWP-051 achieves good alignment of potency, stability, selectivity, and pharmacodynamic effects while maintaining favorable pharmacokinetic properties with once-daily dosing potential in humans.
IWP-051 Preparation Products And Raw materials
Raw materials
Preparation Products
IWP-051 Suppliers
Global( 2)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
TargetMol Chemicals Inc. | 58 |
IWP-051
4(3H)-Pyrimidinone, 5-fluoro-2-[1-[(2-fluorophenyl)methyl]-5-(3-isoxazolyl)-1H-pyrazol-3-yl]-
1354041-91-0