Propargyl-PEG4-(CH2)3-acid
- CAS No.
- 1872433-74-3
- Chemical Name:
- Propargyl-PEG4-(CH2)3-acid
- Synonyms
- Propargyl-PEG4-CH2-acid;5,8,11,14-Tetraoxaheptadec-16-ynoic acid;4,7,10,13-tetraoxaheptadec-1-yn-17-oic acid
- CBNumber:
- CB43363993
- Molecular Formula:
- C13H22O6
- Molecular Weight:
- 274.31
- MDL Number:
- MFCD29079388
- MOL File:
- 1872433-74-3.mol
Propargyl-PEG4-(CH2)3-acid Chemical Properties,Uses,Production
Description
Propargyl-PEG4-(CH2)3-CO2H is a linker containing a propargyl group at one end and a carboxylic acid at the other end. The carboxylic acid reacts with amine groups in the presence of activators (EDC or HATU). Under the catalyzation of copper, the propargyl group forms linkage with azide group of biomolecules.
Uses
Propargyl-PEG4-CH2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-CH2-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Propargyl-PEG4-(CH2)3-acid Preparation Products And Raw materials
Raw materials
Preparation Products
Propargyl-PEG4-(CH2)3-acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42056 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-0431-80514535 19917294565 | et@chemextension.com | China | 3962 | 55 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6355 | 58 | |
| Shaanxi Xinyan Bomei Biotechnology Co., Ltd. | 029-86217788 13892832556 | 2440688701@qq.com | China | 1986 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85563444 18351873721 | purchase@synzest.com | China | 10434 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 3001317055@qq.com | China | 9967 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29774 | 58 |
| Zhejiang Rui 'ao Biological Technology Co.,LTD. | 0573-82087565 18966369783 | gemma_wang@ruiaobio.com | China | 647 | 58 |
1872433-74-3(Propargyl-PEG4-(CH2)3-acid)Related Search:
1of4