2-(4-PIPERAZINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE DIHYDROCHLORIDE
- CAS No.
- 854127-90-5
- Chemical Name:
- 2-(4-PIPERAZINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE DIHYDROCHLORIDE
- Synonyms
- LY-303,511 dihydrochloride;8-phenyl-2-piperazin-1-ylchromen-4-one:dihydrochloride;2-(4-PIPERAZINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE DIHYDROCHLORIDE
- CBNumber:
- CB4338242
- Molecular Formula:
- C19H20Cl2N2O2
- Molecular Weight:
- 379.28
- MDL Number:
- MFCD06801360
- MOL File:
- 854127-90-5.mol
2-(4-PIPERAZINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE DIHYDROCHLORIDE price More Price(3)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 15514 | LY303511 (hydrochloride) ≥98% | 854127-90-5 | 1mg | $47 | 2024-03-01 | Buy |
Cayman Chemical | 15514 | LY303511 (hydrochloride) ≥98% | 854127-90-5 | 5mg | $160 | 2024-03-01 | Buy |
AK Scientific | 5473DW | 2-(4-Piperazinyl)-8-phenyl-4h-1-benzopyran-4-onedihydrochloride | 854127-90-5 | 1mg | $149 | 2021-12-16 | Buy |
2-(4-PIPERAZINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE DIHYDROCHLORIDE Chemical Properties,Uses,Production
Description
LY303511 is a close structural analog of LY294002 , a selective phosphatidylinositol 3-kinase (PI3K) inhibitor.1 LY303511, however, does not inhibit PI3K-dependent phosphorylation of Akt but instead has been shown to inhibit mTOR-dependent phosphorylation of S6K.1 It can reduce cell proliferation in human lung epithelial adenocarcinoma cells, blocking G2/M progression and inhibiting casein kinase 2 activity.1 LY303511 demonstrates tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sensitizing activity in HeLa cells that are refractory to TRAIL-induced apoptosis.2 LY303511 is also reported to block voltage-gated potassium (Kv) channels.3
References
1. Kristof, A.S., Pacheco-Rodriguez, G., Schremmer, B., et al. LY303511 (2-
2. Mellier, G., Liu, D., Bellot, G., et al. Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27 Cell Death Dis. 4,e890(2013).
3. Pattnaik, B.R., and Hughes, B.A. Regulation of Kir channels in bovine retinal pigment epithelial cells by phosphatidylinositol 4,5-
2-(4-PIPERAZINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE DIHYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
2-(4-PIPERAZINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE DIHYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
Supplier | Advantage |
---|---|
Shanghai Hongye Biotechnology Co. Ltd | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 58 |