ChemicalBook >> CAS DataBase List >>PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH

PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH

CAS No.
112208-00-1
Chemical Name:
PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH
Synonyms
sine;P 3C;Pam3CSK4;Pam3CSK41;Pam3CysSK4;Pam3Cys-SKKKK;Pam3Cys-Ser-(Lys)4;PaM3Cys-Ser-(Lys)4 . 3HCl;PAM3-CYS-SER-LYS-LYS-LYS-LYS-OH;PamCys-Ser-(Lys), Hydrochloride
CBNumber:
CB4345219
Molecular Formula:
C81H156N10O13S
Molecular Weight:
1510.23
MDL Number:
MFCD06801383
MOL File:
112208-00-1.mol
Last updated:2023-06-30 15:45:59

PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH Properties

Boiling point 1408.0±65.0 °C(Predicted)
Density 1.054±0.06 g/cm3(Predicted)
storage temp. -15°C
solubility Soluble to 1 mg/ml in 50% Ethanol / H2O
form Lyophilized solid
pka 3.27±0.10(Predicted)

PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 506350 PamCys-Ser-(Lys), Hydrochloride 112208-00-1 2mg $490 2024-03-01 Buy
Tocris 4633 Pam3CSK4 112208-00-1 1 $182 2021-12-16 Buy
Usbiological 256160 Pam3CSK4 112208-00-1 1mg $432 2021-12-16 Buy
Usbiological 256161 Pam3CSK4 112208-00-1 100ug $460 2021-12-16 Buy
ApexBio Technology B5662 Pam3CSK4 112208-00-1 1mg $274 2021-12-16 Buy
Product number Packaging Price Buy
506350 2mg $490 Buy
4633 1 $182 Buy
256160 1mg $432 Buy
256161 100ug $460 Buy
B5662 1mg $274 Buy

PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH Chemical Properties,Uses,Production

General Description

A cell-permeable, water-soluble synthetic cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide, and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. Acts as a selective agonist of TLR2 (Toll-like receptor 2).
A cell-permeable, water-soluble, synthetic, cationic lipohexapeptide analog of the immunologically active N-terminal portion of bacterial lipoprotein that potently activates monocytes and macrophages. Induces the release of IL-1, IL-6, TNF-α, superoxide and NO. Promotes the translocation of NF-κB, enhances tyrosine protein phosphorylation, and activates ERK1/2 and MEK1/2. Acts as a selective TLR-2 (Toll-like receptor 2) agonist.

Biological Activity

pam3csk4 is an agonist of toll-like receptor 1/2 (tlr1/2) [1].toll-like receptors (tlrs) are proteins that play an important role in the innate immune system. tlrs are mainly expressed in sentinel cells that recognize molecules derived from microbes and then activate immune cell responses.pam3csk4 is a tlr1/2 agonist. pam3csk4 increased tyrosine phosphorylation of plcγ2 and the adaptor protein lat in a syk- and src-dependent way. also, pam3csk4 evoked platelet activation [1].in a mouse rhinitis model sensitized to dermatophagoides farinae allergen, pam3csk4 significantly improved the nasal allergic symptoms and reduced total inflammation cells and the eosinophils in bronchoalveolar lavage fluid (balf). also, pam3csk4 significantly increased ifn-γ release and decreased the levels of il-13 and total ige [2]. pam3csk4 induced the production of both no and tnf-ɑ by macrophages [3]. in a murine asthma model challenged with ova, pam3csk4 significantly reduced eosinophilia and total inflammatory cell infiltrate in balf and inhibited the secretion of il-4 and il-5 induced by ova. also, pam3csk4 reduced the level of ige and increased the production of il-12 [4].

storage

Store at -20°C

PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH Preparation Products And Raw materials

Raw materials

Preparation Products

PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH Suppliers

Global( 74)Suppliers
Supplier Tel Email Country ProdList Advantage
Shenzhen Nexconn Pharmatechs Ltd
+86-755-89396905 +86-15013857715 admin@nexconn.com China 10311 58
BOC Sciences
+1-631-485-4226 inquiry@bocsci.com United States 19553 58
Creative Enzymes
1-516-855-7709 info@creative-enzymes.com United States 8748 58
Zhejiang J&C Biological Technology Co.,Limited
+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10473 58
Chengdu Youngshe Chemical Co., Ltd.
+8618108235634 Cecilia@youngshechem.com China 2345 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
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TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Nanjing TGpeptide
+86-13347807150 +86-13347807150 support@tgpeptide.com China 3279 58
Zhejiang Hangyu API Co., Ltd
+8617531972939 anna@api-made.com China 2943 58
Changsha MOL Changes Biotechnology Co., Ltd.
+8619375158599 info@molchanges.com China 5223 58

View Lastest Price from PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Pam3CSK41 pictures 2021-05-07 Pam3CSK41
112208-00-1
US $398.00 / mg 5mg 98% 100mg BOC Sciences
  • Pam3CSK41 pictures
  • Pam3CSK41
    112208-00-1
  • US $398.00 / mg
  • 98%
  • BOC Sciences
PAM3-CYS-SER-LYS-LYS-LYS-LYS-OH PALMITOYL-CYS((RS)-2,3-DI(PALMITOYLOXY)-PROPYL)-SER-LYS-LYS-LYS-LYS-OH n-palmitoyl-s-(2,3-bis(palmitoyloxy)propyl)cysteinyl-seryl-lysyl-lysyl-lysyl-ly sine N-palmitoyl-S-(2,3-bis(palmitoyloxy)propyl)cysteinyl-seryl-lysyl-lysyl-lysyl-lysine PaM3Cys-Ser-Lys-Lys-Lys-Lys-OH, PaM3CSK4 PaM3Cys-Ser-(Lys)4 . 3HCl P 3C Pam3CSK4 Pam3CysSK4 S-[2,3-Bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl-L-lysine Pam3Cys-SKKKK Pam3CSK41 L-Lysine, S-[2,3-bis[(1-oxohexadecyl)oxy]propyl]-N-(1-oxohexadecyl)-L-cysteinyl-L-seryl-L-lysyl-L-lysyl-L-lysyl- Pam3Cys-Ser-(Lys)4 PamCys-Ser-(Lys), Hydrochloride (2S)-6-Amino-2-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-6-amino-2-[(2S)-2-[(2R)-3-{[2,3-bis(hexadecanoyloxy)propyl]sulfanyl}-2-hexadecanamidopropanamido]-3-hydroxypropanamido]hexanamido]hexanamido]hexanamido]hexanoic acid 112208-00-1 C81H156N10O13S Pharmaceutical