LOFEPRAMINE HYDROCHLORIDE
- CAS No.
- 26786-32-3
- Chemical Name:
- LOFEPRAMINE HYDROCHLORIDE
- Synonyms
- db-2182;WHR 2908A;WHR-2908A;ropylaminehcl;LOFEPRAMINE HCL;acetophenonehcl;leo640hydrochloride;iopraminehydrochloride;lopraminehydrochloride;clopepraminehydrochloride
- CBNumber:
- CB4351274
- Molecular Formula:
- C26H28Cl2N2O
- Molecular Weight:
- 455.42
- MDL Number:
- MFCD00941486
- MOL File:
- 26786-32-3.mol
- MSDS File:
- SDS
Melting point | 152-154° |
---|---|
Flash point | 9℃ |
storage temp. | 2-8°C |
solubility | DMSO: ~24 mg/mL |
form | solid |
color | off-white |
FDA UNII | Z24K96F991 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS02,GHS05,GHS06,GHS08 |
---|---|
Signal word | Danger |
Hazard statements | H225-H290-H301+H311+H331-H370 |
Precautionary statements | P210-P280-P302+P352+P312-P304+P340+P312-P370+P378-P403+P235 |
Hazard Codes | Xn |
Risk Statements | 22-37-53 |
Safety Statements | 22-24/25-26-28-36/37/39-38 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 2 |
RTECS | AM6485000 |
Toxicity | LD50 in mice, rats (mg/kg): >2500, >1000 orally; 920, >1000 i.p.; >1000, >1000 s.c. (Eriksoo, Rohte) |
LOFEPRAMINE HYDROCHLORIDE price More Price(2)
LOFEPRAMINE HYDROCHLORIDE Chemical Properties,Uses,Production
Originator
Gamonil,E. Merck
Uses
Monoamine reuptake inhibitor; tricyclic antidepressant.
Uses
Lofepramine Hydrochloride is a tricyclic anti-depressent drug. Potent inhibitor of noradenaline uptake.
Definition
ChEBI: Lofepramine hydrochloride is a hydrochloride. It has a role as an antidepressant. It contains a lofepramine.
Manufacturing Process
9.8 parts of 10,11-dihydro-5H-dibenzo[b,f]azepine are dissolved in 10 parts of
dry toluene and 3.1 parts of sodium amide are added and the mixture is
refluxed and stirred for four hours. A solution of 13.5 parts of 1-(4-
chlorophenyl)-2-[(3-chloropropyl)methylamino]ethanone in 20 parts of dry
toluene is added dropwise and the mixture is stirred and refluxed for eight
hours.
After cooling to room temperature water is carefully added to the reaction
mixture and the toluene solution is extracted with water to which hydrochloric
acid is added so that the aqueous phase obtains the pH-value of 5. The
aqueous extract is discarded and the toluene phase is evaporated to dryness
in vacuum. The residue is dissolved in 50 parts of methanol. Hydrogen gas is
introduced to give the crystalline hydrochloride 1-(4-chlorophenyl)-2-((3-
(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)propyl)methylamino)ethanone;
MP: 154°-156°C. The hydrochloride may be removed by adding an equivalent
of any base (triethyl amine, sodium hydroxide and so on).
Therapeutic Function
Antidepressant
LOFEPRAMINE HYDROCHLORIDE Preparation Products And Raw materials
LOFEPRAMINE HYDROCHLORIDE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Xi'an ZB Biotech Co.,Ltd | +8618591943808 | sales01@xazbbio.com | China | 816 | 58 |
Finetech Industry Limited | +86-27-87465837 +8618971612321 | info@finetechnology-ind.com | China | 9640 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50003 | 58 |
LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2127 | 70 |
Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9649 | 58 |
Hangzhou ChangCun Biotechnology Co., Ltd. | 0571-; 13567100326 | 158848739@qq.com | China | 108 | 50 |
Supplier | Advantage |
---|---|
BOC Sciences | 58 |
TargetMol Chemicals Inc. | 58 |
Xi'an ZB Biotech Co.,Ltd | 58 |
Finetech Industry Limited | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 58 |
Alfa Chemistry | 58 |
GIHI CHEMICALS CO.,LIMITED | 58 |
LGM Pharma | 70 |
Finetech Industry Limited | 58 |
Hangzhou ChangCun Biotechnology Co., Ltd. | 50 |