Latamoxef sodium | 64953-12-4

Latamoxef sodium Properties

Melting point	>156oC (dec.)
alpha	D22 -45° (water)
storage temp.	Inert atmosphere,2-8°C
solubility	Methanol (Slightly)
form	White to Pale Yellow
color	White to off-white
Merck	13,6311
Stability	Unstable in solution (DMSO or Methanol)
InChIKey	GRIXGZQULWMCLU-GDUWRUPCSA-L
FDA UNII	5APW73W3QZ

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H317-H334
Precautionary statements	P261-P280-P342+P311
Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	22-36/37-45
WGK Germany	2
RTECS	RN6824000

Latamoxef sodium price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	M8158	Moxalactam sodium salt analytical standard	64953-12-4	1g	$233	2024-03-01	Buy
Sigma-Aldrich	M8158	Moxalactam sodium salt analytical standard	64953-12-4	5g	$761	2024-03-01	Buy
Alfa Aesar	J67056	Moxalactam sodium salt, 50 mg/ml in distilled water, sterile-filtered	64953-12-4	1ml	$71.7	2023-06-20	Buy
Alfa Aesar	J67056	Moxalactam sodium salt, 50 mg/ml in distilled water, sterile-filtered	64953-12-4	5x1ml	$200	2023-06-20	Buy
Cayman Chemical	15869	Moxalactam (sodium salt) ≥85% (mixture of isomers)	64953-12-4	250mg	$64	2024-03-01	Buy

Product number	Packaging	Price	Buy
M8158	1g	$233	Buy
M8158	5g	$761	Buy
J67056	1ml	$71.7	Buy
J67056	5x1ml	$200	Buy
15869	250mg	$64	Buy

Latamoxef sodium Chemical Properties,Uses,Production

Description

Latamoxef was synthesized by Shionogi Pharmaceuticals in 1975 starting with benzylpenicillin and using a novel drug design. The oxacephem nucleus, in which the sulfur atom had been replaced by oxygen, was substituted with a methoxyl group at the 7α position, as in the cephamycins. A carboxyl moiety and a hydroxybenzyl group were added at the 7β position, as in carbenicillin, and a methyltetrazolylthiomethyl group was attached at the 3 position. These substitutions resulted in a strong activity against gram-negative bacteria and a high resistance to the action of βlactamase, along with excellent activity against Pseudomonas aeruginosa, even though the compound has no activity against Staphylococcus aureus.

Originator

Moxam,Lilly,US,1981

Uses

Moxalactam Sodium is an oxacephem antibiotic. Moxalactam Sodium is more effective against Escherichia coli and Pseudomonas aeruginosa than cephalosporins.

Uses

Antibacterial;Bacterial transpeptidase inhibitor

Manufacturing Process

To a stirred suspension of p-(p-methoxybenzyloxy)-phenylmalonic acid (125 mg) in methylene chloride (3 ml) are added triethylamine (55 l) and oxalyl chloride (26 l) at -15°C, and the suspension is stirred for 40 minutes at 0°C. The mixture is added to a solution of diphenylmethyl 7β-amino-7α-methoxy-3- (1-methyltetrazol-5-yl)thiomethyl-1-oxadethia-3-cephem-4-carboxylate (100 mg) in methylene chloride (3 ml) and pyridine (63 l), and the mixture is stirred for 30 minutes at 0°C. The reaction mixture is diluted with ethyl acetate, washed with aqueous 2N-hydrochloric acid and water, dried over sodium sulfate, and concentrated to give crude product (212 mg), which is chromatographed on silica gel (20 g) and eluted with a mixture of ethyl acetate and acetic acid (99:1) to give diphenylmethyl-7β-[α-p-(pmethoxybenzyloxy)phenyl-α-carboxyacetamido]-7α-methoxy-3-(1- methyltetrazol-5yl)thiomethyl-1-oxadethia-3-cephem-4-carboxylate as foam (71 mg). Yield: 45%.
To a solution of diphenylmethyl-7β-[α-p-(p-methoxybenzyl)-oxy-phenyl-α-pmethoxybenzyl-oxycarbonil-acetamido]-7α-methoxy-3-(1-methyltetrazol-5- yl)thiomethyl-1-oxadethia-3-cephem-4-carboxylate (1.20 g) in methylene chloride (24 ml) are added anisole (2.4 ml) and a solution of aluminum chloride (2.58 g) in nitromethane (12 ml) at 0°C under nitrogen. After stirring for 15 minutes at 0°C, the mixture is poured into cold 5% sodium hydrogen carbonate aqueous solution (100 ml) and filtered to remove the formed precipitate. The filtate is washed twice with methylene chloride (2 x 100 ml), acidified with 2N-hydrochloric acid to pH 2.60, and poured in a column of high porous polymer HP-20 (60 ml) sold by Mitsubishi Chemical Industries Ltd. The column is washed with water (300 ml) and eluted with methanol. The eluate is concentrated under reduced pressure at room temperature. The residue is dissolved in methanol, treated with active carbon, and concentrated under reduced pressure to give 7β(α-p-hydroxyphenyl-α-carboxyacetamido)-7β- methoxy-3-(1-methyl-tetrazol-5-yl)thiomethyl1-oxadethia-3-cephem-4- carboxylic acid as powder (595 mg) decomposing at 125°C to 132°C. Yield: 88.5%.
To a solution of 7β(α-p-hydroxyphenyl-α-carboxyacetamido)-7α-methoxy-3-(1- methyl-tetrazol-5-yl)thiomethyl1-oxadethia-3-cephem-4-carboxylic acid (359 mg) in methanol (7 ml) is added a solution of sodium 2-ethylhexanoate in methanol (2 mols/liter; 1.73 ml) at room temperature. After stirring for 10 minutes, the reaction mixture is diluted with ethyl acetate, stirred for 5 minutes, and filtered to collect separated solid, which is washed with ethyl acetate, and dried to give disodium salt of 7β(α-p-hydroxyphenyl-α- carboxyacetamido)-7α-methoxy-3-(1-methyl-tetrazol-5-yl)thiomethyl1- oxadethia-3-cephem-4-carboxylic acid (342 mg). Yield: 888%. Colorless powder. MP decomposition from 170°C.

brand name

Moxam (Lilly).

Therapeutic Function

Antiinfective

Biological Activity

moxalactam (sodium salt) is a β-lactam antibiotic.β-lactam antibiotics (beta-lactam antibiotics) are a class of broad-spectrum antibiotics that contain a beta-lactam ring in their molecular structures. most β-lactam antibiotics act by inhibiting cell wall biosynthesis.moxalactam is an oxacephem antibiotic and inhibits most commonly occurring gram positive, gram negative, and anaerobic bacteria. moxalactam was more active against klebsiella and e coli than cefoperazone. moxalactam did not inhibit methicillin-resistant s. aureus and enterococci. moxalactam had been extremely active against haemophilis and neisseria gonorrhoeae. moxalactam was extremely resistant to hydrolysis by all plasmid and chromosmal β-lactamases [1]. in certain situations, moxalactam impaired normal hemostasis and prolonged bleeding time [2].

References

[1]. neu hc. the in vitro activity, human pharmacology, and clinical effectiveness of new beta-lactam antibiotics. annu rev pharmacol toxicol. 1982;22:599-642.
[2]. sattler fr, weitekamp mr, ballard jo. potential for bleeding with the new beta-lactam antibiotics. ann intern med. 1986 dec;105(6):924-31.

Latamoxef sodium Preparation Products And Raw materials

Raw materials

Aluminum chloride Sodium 2-ethylhexanoate

Preparation Products

Latamoxef sodium Suppliers

Global( 208)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618092446649	sarah@tnjone.com	China	1143	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29882	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58

Supplier	Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Shandong chuangyingchemical Co., Ltd.	58
Chongqing Chemdad Co., Ltd	58
Shenzhen Excellent Biotech Co., Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
TargetMol Chemicals Inc.	58
ANHUI WITOP BIOTECH CO., LTD	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from Latamoxef sodium manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Moxalactam sodium salt 64953-12-4	US $29.00 / mg		93.33%	10g	TargetMol Chemicals Inc.
2024-04-29	latamoxefsodium 64953-12-4	US $0.00 / kg	1kg	99%	20tons	Shaanxi TNJONE Pharmaceutical Co., Ltd
2024-04-10	Latamoxef Sodium 64953-12-4	US $0.00-0.00 / mg	10mg	90%+	10g	Guangzhou PI PI BIOTECH INC

Moxalactam sodium salt
64953-12-4
US $29.00 / mg
93.33%
TargetMol Chemicals Inc.

latamoxefsodium
64953-12-4
US $0.00 / kg
99%
Shaanxi TNJONE Pharmaceutical Co., Ltd

Latamoxef Sodium
64953-12-4
US $0.00-0.00 / mg
90%+
Guangzhou PI PI BIOTECH INC

Latamoxef sodium Spectrum

Latamoxef sodium(64953-12-4)MS

64953-12-4(Latamoxef sodium)Related Search:

Sodium hydroxide Trisodium phosphate 4-Methoxyphenylacetone Sodium citrate p-Anisaldehyde

Latamoxef Cefonicid sodium Sodium nitrite Acetyl chloride Acetylacetone

Cefotaxime sodium Ethylenediaminetetraacetic acid disodium salt Diclofenac sodium p-Anisidine Sodium acetate

Cefoperazone sodium +sulbactam sodium(1:1/2:1) Sodium chloride (Trifluoromethoxy)benzene

1of4

MOXALACTAM SODIUM SALT 5-oxa-1-azabicyclo(4.2.o)oct-2-ene-2-carboxylicacid,7-((carboxy(4-hydroxyphen 6059s antibiotic6059-s disodiumlatamoxef latamoxefsodium ly127935 moxalactamdisodium moxam moxalactam sodium moxalactam sodium salt, mixture of isomers disodium 7-[[carboxylato(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-carboxy(4-hydroxyphenyl)acetyl]amino]-7-methoxy-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, disodium salt, (6R,7R)- (9CI) Festamoxin LY 12735 S 6059 Shiomarin Shionogi 6059S (6R,7R)-7-[2-Carboxy-2-(p-hydroxyphenyl)acetylamino]-7-methoxy-3-(1-methyl-1H-tetrazol-5-ylthiomethyl)-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid disodium salt 5-Oxa-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((carboxy(4-hydroxyphenyl)acetyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, disodium salt Einecs 265-288-4 Moxalactam Disodium (500 mg) 5-Oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[(2R)-2-carboxy-2-(4-hydroxyphenyl)acetyl]aMino]-7-Methoxy-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-,sodiuM salt (1:2), (6R,7R)- (6R,7R)-7-[[(2R)-Carboxy(4-hydroxyphenyl)acetyl]aMino]-7-Methoxy-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid DisodiuM Salt MoxalactaM SodiuM Salt (Mixture of diastereoMers) Moxalactam sodium, >=830 μg/mg Latamoxef Disodium HY-B1484 FestamoxinLy Latamoxef sodium USP/EP/BP Latamoxef sodiumr Moxalactam Sodium Salt (Mixture of Diastereomers) (10mM in DMSO) TIANFU-CHEM CAS NO.64953-12-4 Latamoxef sodium Latamoxef sodium, CAS:64953-12-4 Sodium (6R,7R)-7-((R)-2-carboxylato-2-(4-hydroxyphenyl)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate Moxalactam Sodium Salt (Latamoxef Sodium) (6R,7R)-7-((R)-2-carboxy-2-(4-hydroxyphenyl)acetamido)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-oxa-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, sodium salt Laxocefuroxime sodium 64953-12-4 4953-12-4 C20H18N6Na2O9S C20H18N6O9S2Na Antibiotics G-M Antibiotics Antibiotics A to Z BioChemical Inhibitors Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds METI - MZForensic and Veterinary Standards OthersAntibiotics Penicillins and Cephalosporins (beta-Lactams)More...Close... Antibacterial Antibiotics Antibiotics A to