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RO 31-8220 METHANESULFONATE

RO 31-8220 METHANESULFONATE Structure
RO 31-8220 METHANESULFONATE structure
CAS No.
125314-64-9
Chemical Name:
RO 31-8220 METHANESULFONATE
Synonyms
RO-31-8220;RO 31-8220 MESYLATE;BisindolylMaleiMide IX;Bisindoylmaleimidine IX;RO 31-8220 METHANESULFONATE;Ro 31-8220 methanesulfonate salt;BISINDOLYLMALEIMIDE IX METHANESULFONATE;BISINDOYLMALEIMIDINE IX METHANESULFONATE;Ro 31-8220 mesylate (Bisindolylmaleimide IX);3-[1-3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL) MALEIMIDE
CBNumber:
CB4355393
Molecular Formula:
C25H23N5O2S
Molecular Weight:
457.55
MDL Number:
MFCD00236436
MOL File:
125314-64-9.mol
MSDS File:
SDS
Last updated:2023-05-18 11:31:16
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RO 31-8220 METHANESULFONATE Properties

Density 1.42±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility H2O: 7.3 mg/mL
pka 7.90±0.60(Predicted)
form solid
color orange to red
FDA UNII W9A0B5E78O

SAFETY

Risk and Safety Statements

WGK Germany  3

RO 31-8220 METHANESULFONATE price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Tocris 2002 Ro31-8220mesylate ≥97%(HPLC) 125314-64-9 10 $270 2021-12-16 Buy
Usbiological 256481 Ro 31-8220 mesylate 125314-64-9 10mg $531 2021-12-16 Buy
Biorbyt Ltd orb181118 Ro 31-8220 mesylate >98% 125314-64-9 100mg $615.4 2021-12-16 Buy
American Custom Chemicals Corporation KIN0000215 RO-31-8220 95.00% 125314-64-9 1MG $664.82 2021-12-16 Buy
ApexBio Technology B1287 Ro31-8220 125314-64-9 50mg $399 2021-12-16 Buy
Product number Packaging Price Buy
2002 10 $270 Buy
256481 10mg $531 Buy
orb181118 100mg $615.4 Buy
KIN0000215 1MG $664.82 Buy
B1287 50mg $399 Buy

RO 31-8220 METHANESULFONATE Chemical Properties,Uses,Production

Uses

Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.

Definition

ChEBI: Ro 31-8220 is an imidothiocarbamic ester, a member of indoles and a member of maleimides. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor. It is functionally related to a maleimide.

Biological Activity

Protein kinase C inhibitor, with activity at other protein kinases (IC 50 values are 33, 3, 8, 15 and 38 nM for PKC α , MAPKAP-K1b, MSK1, GSK3 β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na + channels in the micromolar range.

References

[1]. wilkinson se, parker pj, nixon js. isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase c. biochem j, 1993, 294 ( pt 2): 335-337.
[2]. beltman j, mccormick f, cook sj. the selective protein kinase c inhibitor, ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (mkp-1) expression, induces c-jun expression, and activates jun n-terminal kinase. j biol chem, 1996, 271(43): 27018-27024.
[3]. geiselhart l, conti dj, freed bm. ro 31-8220, a novel protein kinase c inhibitor, inhibits early and late t cell activation events. transplantation, 1996, 61(11): 1637-1642.
[4]. standaert ml, bandyopadhyay g, antwi ek, et al. ro 31-8220 activates c-jun n-terminal kinase and glycogen synthase in rat adipocytes and l6 myotubes. comparison to actions of insulin.

RO 31-8220 METHANESULFONATE Preparation Products And Raw materials

Raw materials

Preparation Products

RO 31-8220 METHANESULFONATE Suppliers

Global( 75)Suppliers
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Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30253 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43348 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131980 58
Shanghai Boyle Chemical Co., Ltd. sales@boylechem.com China 2923 55
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
ChemCell Biomedicine Co.,Ltd. 020-13556033878 2965585218 13556033878 chemcell@hotmail.com China 369 52
SpringPharma Tech Co.,Ltd +86-25-68710855, +86-25-68710897 sales@springpharma.net China 1261 62
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4863 58
LETOPHARM LIMITED +86-21-5821 5861 sales@letopharm.com China 2384 58
Supplier Advantage
Career Henan Chemica Co 		58
InvivoChem 		58
LEAPCHEM CO., LTD. 		58
Amadis Chemical Company Limited 		58
Shanghai Boyle Chemical Co., Ltd. 55
3B Pharmachem (Wuhan) International Co.,Ltd. 69
ChemCell Biomedicine Co.,Ltd. 52
SpringPharma Tech Co.,Ltd 62
MedChemexpress LLC 58
LETOPHARM LIMITED 58

125314-64-9(RO 31-8220 METHANESULFONATE)Related Search:

Silver GF109203X RO 31-8220 (BISINDOYLMALEIMIDINE IX) RO-31-8220 3,4-Di-1H-indol-3-yl-1H-pyrrole-2,5-dione
RO 31-8220 METHANESULFONATE

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BISINDOLYLMALEIMIDE IX METHANESULFONATE BISINDOYLMALEIMIDINE IX METHANESULFONATE RO-31-8220 RO 31-8220 MESYLATE RO 31-8220 METHANESULFONATE 3-[3-[2,5-DIHYDRO-4-(1-METHYL-1H-INDOL-3-YL)-2,5-DIOXO-1H-PYRROL-3-YL]-1H-INDOL-1-YL]PROPYL CARBAMIMIDOTHIOIC ACID ESTER MESYLATE 3-[1-3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL) MALEIMIDE 3-[1-[3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE METHANESULFONATE 2-[1-[3-(AMIDINOTHIO)PROPYL]-1H-INDOL-3-YL]-3-(1-METHYLINDOL-3-YL)-MALEIMIDE METHANESULFONATE BisindolylMaleiMide IX 2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate salt Bisindoylmaleimidine IX Ro 31-8220 methanesulfonate salt 3-[1-[3-(Amidinothio)propyl-1H-indol-3-yl]-3-(1-methyl-1H-indol-3-yl)maleimide] meslate Ro 31-8220 mesylate (Bisindolylmaleimide IX) Carbamimidothioic acid, 3-(3-(2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl)-1H-indol-1-yl)propyl ester 125314-64-9 C25H23N5O2SCH3SO3H Protein Kinase