RO 31-8220 METHANESULFONATE
- CAS No.
- 125314-64-9
- Chemical Name:
- RO 31-8220 METHANESULFONATE
- Synonyms
- RO-31-8220;RO 31-8220 MESYLATE;BisindolylMaleiMide IX;Bisindoylmaleimidine IX;RO 31-8220 METHANESULFONATE;Ro 31-8220 methanesulfonate salt;BISINDOLYLMALEIMIDE IX METHANESULFONATE;BISINDOYLMALEIMIDINE IX METHANESULFONATE;Ro 31-8220 mesylate (Bisindolylmaleimide IX);3-[1-3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL) MALEIMIDE
- CBNumber:
- CB4355393
- Molecular Formula:
- C25H23N5O2S
- Molecular Weight:
- 457.55
- MDL Number:
- MFCD00236436
- MOL File:
- 125314-64-9.mol
- MSDS File:
- SDS
| Density | 1.42±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | H2O: 7.3 mg/mL |
| pka | 7.90±0.60(Predicted) |
| form | solid |
| color | orange to red |
| FDA UNII | W9A0B5E78O |
| UNSPSC Code | 12352200 |
RO 31-8220 METHANESULFONATE price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 2002 | Ro31-8220mesylate ≥97%(HPLC) | 125314-64-9 | 10 | $270 | 2021-12-16 | Buy |
| Usbiological | 256481 | Ro 31-8220 mesylate | 125314-64-9 | 10mg | $531 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb181118 | Ro 31-8220 mesylate >98% | 125314-64-9 | 100mg | $615.4 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000215 | RO-31-8220 95.00% | 125314-64-9 | 1MG | $664.82 | 2021-12-16 | Buy |
| ApexBio Technology | B1287 | Ro31-8220 | 125314-64-9 | 50mg | $399 | 2021-12-16 | Buy |
RO 31-8220 METHANESULFONATE Chemical Properties,Uses,Production
Uses
Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor.
Definition
ChEBI: Ro 31-8220 is an imidothiocarbamic ester, a member of indoles and a member of maleimides. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor. It is functionally related to a maleimide.
Biological Activity
Protein kinase C inhibitor, with activity at other protein kinases (IC 50 values are 33, 3, 8, 15 and 38 nM for PKC α , MAPKAP-K1b, MSK1, GSK3 β and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na + channels in the micromolar range.
References
[1]. wilkinson se, parker pj, nixon js. isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase c. biochem j, 1993, 294 ( pt 2): 335-337.
[2]. beltman j, mccormick f, cook sj. the selective protein kinase c inhibitor, ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (mkp-1) expression, induces c-jun expression, and activates jun n-terminal kinase. j biol chem, 1996, 271(43): 27018-27024.
[3]. geiselhart l, conti dj, freed bm. ro 31-8220, a novel protein kinase c inhibitor, inhibits early and late t cell activation events. transplantation, 1996, 61(11): 1637-1642.
[4]. standaert ml, bandyopadhyay g, antwi ek, et al. ro 31-8220 activates c-jun n-terminal kinase and glycogen synthase in rat adipocytes and l6 myotubes. comparison to actions of insulin.
RO 31-8220 METHANESULFONATE Preparation Products And Raw materials
Raw materials
Preparation Products
RO 31-8220 METHANESULFONATE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30233 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| ChemCell Biomedicine Co.,Ltd. | 020-13556033878 2965585218 13556033878 | chemcell@hotmail.com | China | 369 | 52 |
| SpringPharma Tech Co.,Ltd | +86-25-68710855, +86-25-68710897 | sales@springpharma.net | China | 1261 | 62 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
View Lastest Price from RO 31-8220 METHANESULFONATE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-10-28 | Ro 31-8220
125314-64-9
|
US $2500.00-1980.00 / mg | 10g | TargetMol Chemicals Inc. |
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- Ro 31-8220
125314-64-9
- US $2500.00-1980.00 / mg
- TargetMol Chemicals Inc.