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ChemicalBook >> CAS DataBase List >>3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE

3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE

3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Structure
3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE structure
CAS No.
676599-90-9
Chemical Name:
3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE
Synonyms
APHA-8;MC1353;MC-1353;MC 1353;APHA COMPOUND 8;Aroyl pyrrole hydroxy amide #8;3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE;(E)-N-hydroxy-3-(1-Methyl-4-(2-phenylacetyl)-1H-pyrrol-2-yl)acrylaMide;2-Propenamide, N-hydroxy-3-[1-methyl-4-(2-phenylacetyl)-1H-pyrrol-2-yl]-
CBNumber:
CB4360159
Molecular Formula:
C16H16N2O3
Molecular Weight:
284.31
MDL Number:
MFCD05865226
MOL File:
676599-90-9.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:49
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3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Properties

storage temp. 2-8°C
solubility DMSO: 10 mg/mL, soluble
form solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H317-H318
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
Hazard Codes  Xn
Risk Statements  22-41-43
Safety Statements  26-36/37/39
WGK Germany  2
NFPA 704
0
3 0

3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE price More Price(4)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A2478 APHA Compound 8 ≥98% (HPLC), solid 676599-90-9 1mg $156 2024-03-01 Buy
Cayman Chemical 21228 APHA Compound 8 676599-90-9 500μg $62 2024-03-01 Buy
Cayman Chemical 21228 APHA Compound 8 676599-90-9 1mg $92 2024-03-01 Buy
AK Scientific 3575DN 3-(1-Methyl-4-phenylacetyl-1H-2-pyrrolyl)-N-hydroxy-2-propenamide 676599-90-9 1mg $199 2021-12-16 Buy
Product number Packaging Price Buy
A2478 1mg $156 Buy
21228 500μg $62 Buy
21228 1mg $92 Buy
3575DN 1mg $199 Buy

3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Chemical Properties,Uses,Production

Description

APHA compound 8 is an inhibitor of class I histone deacetylases (HDACs; IC50s = 3.7, 7.4, 0.42, and 2.8 μM for HDAC1, -2, -3, and -8, respectively) as well as class II HDACs (IC50s = 3.1, 0.1, 3.1, and 4.2 μM for HDAC4, -6, -7, and -10, respectively). It is selective for class I and II HDACs over class III HDACs (IC50s = >30 μM for SIRT1, SIRT2, and SIRT3) and the histone acetyltransferase PCAF (IC50 = >30 μM). At 48 hours post-infection, APHA compound 8 increases replication of oncolytic herpes simplex virus (oHSV) in MDA-MB-231 and 4T1 breast cancer cells when used prior to viral infection at concentrations of 10 and 50 μM.

3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE Suppliers

Global( 25)Suppliers
Supplier Tel Email Country ProdList Advantage
Creative Enzymes 		1-516-855-7709 info@creative-enzymes.com United States 8748 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52927 58
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
Syntechem Co.,Ltd info@syntechem.com China 12990 57
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
BOC Sciences -- info@bocsci.com USA 0 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24017 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Supplier Advantage
Creative Enzymes 		58
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
VDM Biochemicals 64
Syntechem Co.,Ltd 57
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
3-(1-METHYL-4-PHENYLACETYL-1H-2-PYRROLYL)-N-HYDROXY-2-PROPENAMIDE APHA COMPOUND 8 (E)-N-hydroxy-3-(1-Methyl-4-(2-phenylacetyl)-1H-pyrrol-2-yl)acrylaMide 2-Propenamide, N-hydroxy-3-[1-methyl-4-(2-phenylacetyl)-1H-pyrrol-2-yl]- APHA-8 Aroyl pyrrole hydroxy amide #8 MC 1353 MC1353 MC-1353 676599-90-9 Biochemicals and Reagents BioChemical Histone deacetylase D to K Enzyme Inhibitors Enzyme Inhibitors by Enzyme Enzymes, Inhibitors, and Substrates Histone Deacetylase (HDAC) inhibitor.