Bakuchiol
- CAS No.
- 10309-37-2
- Chemical Name:
- Bakuchiol
- Synonyms
- BAKUCHIOL;Backuchiol;Drupanol;(S,E)-4-(3,7-dimethyl-3-vinylocta-1,6-dien-1-yl)phenol;UP 256;BAKUCHIOL;Aids046581;Aids-046581;98%Bakuchiol;BAKUCHIOL(SH)
- CBNumber:
- CB4365255
- Molecular Formula:
- C18H24O
- Molecular Weight:
- 256.38
- MDL Number:
- MFCD01707441
- MOL File:
- 10309-37-2.mol
- MSDS File:
- SDS
| Boiling point | 391℃ |
|---|---|
| Density | 0.963 |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.4500 (estimate) |
| Flash point | 177℃ |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml) |
| form | Liquid |
| pka | 10.10±0.26(Predicted) |
| color | Oil |
| optical activity | [α]/D +24.0 to +30.0°, c = 0.1 in chloroform |
| BRN | 3611720 |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| InChIKey | LFYJSSARVMHQJB-WYMLVPIESA-N |
| LogP | 5.09 at 20℃ and pH6.31 |
| Surface tension | 43.92mN/m at 1g/L and 20℃ |
| EWG's Food Scores | 1 |
| FDA UNII | OT12HJU3AR |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H332-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| WGK Germany | 3 |
| RTECS | SL3785000 |
| Toxicity | LD50 orl-mus: 2560 mg/kg MZHUDX 42,646,80 |
Bakuchiol price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SMB00604 | Bakuchiol ≥95% | 10309-37-2 | 20mg | $313 | 2024-03-01 | Buy |
| Sigma-Aldrich | 68612 | Bakuchiol analytical standard | 10309-37-2 | 10mg | $262 | 2022-05-15 | Buy |
| Cayman Chemical | 11684 | Bakuchiol ≥95% | 10309-37-2 | 5mg | $53 | 2024-03-01 | Buy |
| Cayman Chemical | 11684 | Bakuchiol ≥95% | 10309-37-2 | 10mg | $98 | 2024-03-01 | Buy |
| Cayman Chemical | 11684 | Bakuchiol | 10309-37-2 | 25mg | $221 | 2024-03-01 | Buy |
Bakuchiol Chemical Properties,Uses,Production
Description
Bakuchiol (10309-37-2) is a natural terpenoid antioxidant.It has the follow effects: 1.Inhibits oxidative stress-induced decrease in mitochondrial membrane potential and associated release of pro-apoptotic factors.2.Protects against acute lung injury.3.Displays neuroprotective and anti-inflammatory effects.
Uses
(S)-Bakuchiol is a meroterpen found in the medicinal resinous shrub Psoralea glandulosa. An analogue of Resveratrol (R150000) with antifungal and anti-tumor effects. Studies have shown that Bakuchiol is a potent cytotoxic agent that exhibiting concentration dependent growth inhibition against leukemia cancer cells.
Biological Activity
Bakuchiol (BAK) has various pharmacological effects such as antioxidant, anti-aging, anti-inflammatory, antimicrobial, antidiabetic, cardioprotective, and estrogen-like effects. BAK exhibits antimicrobial activity against oral microorganisms such as Streptococcus mutans. It is also a DNA polymerase inhibitor and showed anti-tumour activity in human lung adenocarcinoma A549 cells. BAK showed hepatoprotective activity in vitro and in vivo against liver injury in rats.
Safety Profile
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.When heated to decomposition it emits acrid smoke andfumes.
Mode of action
The research found that BAK upregulates the expression of the antiapoptotic molecule Bcl2 and downregulates the expression of the proapoptotic molecules Bax and caspase-3 by activating the silent information regulator 1 (SIRT1) signaling pathway and thereby inhibits mitochondrial damage and ameliorates myocardial IRI. BAK promotes apoptosis in hepatic astrocytes through the caspase-3-dependent pathway and inhibits liver fibrosis. In addition, BAK exerts a protective effect against hepatotoxicity induced by tert-butyl hydroperoxide (tBH), tetrachloromethane (CCl4), and d-galactosamine (D-GalN). BAK (60?mg/kg) treatment significantly reduces edema and pathological changes in lung tissues by inhibiting intense inflammation and exerting protective effects in the lung under sepsis conditions[5-6].
References
1) Adhikari et al. (2007), Physico-chemical studies on the evaluation of the antioxidant activity of herbal extracts and active principles of some Indian medicinal plants; J. Clin. Biochem. Nutr., 40 174
2) Kim et al. (2013), Protective effects of the compounds isolated from the seed of Psoralea corylifolia on oxidative stress-induced retinal damage; Toxicol. Appl. Pharmacol., 269 109
3) Zhang et al. (2017), Bakuchiol protects against acute lung injury in septic mice; Inflammation, 40 351
4) Kim et al. (2016), Quantitative Analysis of Psoralea corylifolia Linne and its Neuroprotective and Anti-Neuroinflammatory Effects in HT22 Hippocampal Cells and BV-2 Microglia; Molecules, 21 E1076
[5] Zhenlong Xin . “Bakuchiol: A newly discovered warrior against organ damage.” Pharmacological research 141 (2019): Pages 208-213.
[6] Jianyu Feng. “Bakuchiol attenuates myocardial ischemia reperfusion injury by maintaining mitochondrial function: the role of silent information regulator 1.” Apoptosis 71 1 (2016): 532–545.
Bakuchiol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Tauto Biotech Co., Ltd. | +86-021-51320588 | export@tautobiotech.com | China | 2 | 58 |
| Chemsigma International Co., Ltd. | +86-18136843612 +86-19951791336 | info@chemsigma.com | China | 1369 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 | gao490372054@gamil.com | China | 1249 | 58 |
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | sales006@ingredients-lonier.com | China | 2608 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 423 | 58 |
| Sinoway Industrial co., ltd. | 0592-5800732; +8613806035118 | xie@china-sinoway.com | China | 988 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1001 | 58 |
| Wuhan Haorong Biotechnology Co.,ltd | +86-18565342920; +8618565342920 | sales@chembj.net | China | 289 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20284 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
Related articles
- Anti-aging effects of Bakuchiol
- Bakuchiol (BAK), a meroterpene phenol abundant in the plant Psoralea corylifolia, is an emerging cosmeceutical agent with prom....
- Dec 26，2023
View Lastest Price from Bakuchiol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-23 | Bakuchiol
10309-37-2
|
US $0.00-0.00 / Kg/Bag | 1Kg/Bag | 98.5% up / EP | 20 tons | Sinoway Industrial co., ltd. | |
 |
2024-12-23 | Bakuchiol
10309-37-2
|
US $100.00-75.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2024-12-23 | Bakuchiol
10309-37-2
|
US $35.00 / kg | 1kg | 99% | 5000kg/Week | Hebei Zhuanglai Chemical Trading Co.,Ltd |