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3-(2-Pyrrolidinyl)pyridine

3-(2-Pyrrolidinyl)pyridine Structure
3-(2-Pyrrolidinyl)pyridine structure
CAS No.
5746-86-1
Chemical Name:
3-(2-Pyrrolidinyl)pyridine
Synonyms
DL-NORNICOTINE;(R,S)-NORNICOTINE;(±)-Nornicotine;NORNICOTINE, DL-;Nicotine USP RC F;(+/-)-nornicotine;DL-Nornicotine,96%;beta-dl-nornicotine;(+ -)-NORNICOTINE 98+%;Sertindole Impurity 20
CBNumber:
CB4385206
Molecular Formula:
C9H12N2
Molecular Weight:
148.21
MDL Number:
MFCD00016913
MOL File:
5746-86-1.mol
Last updated:2025-03-06 08:32:39
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3-(2-Pyrrolidinyl)pyridine Properties

Melting point 235-236 °C(Solv: ethanol (64-17-5))
Boiling point 107-108°C 2mm
Density 1,074 g/cm3
refractive index 1.54
Flash point 101°C
storage temp. 2-8°C
solubility H2O: 50 mg/mL
form liquid
pka 9.09±0.10(Predicted)
color yellow
Specific Gravity 1.074
Water Solubility Soluble in acetone, chloroform and water (50mg/ml).
Merck 14,6712
BRN 81968
Stability Hygroscopic, Light Sensitive, Moisture Sensitive
CAS DataBase Reference 5746-86-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 83H6L5QD8Z
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338
Hazard Codes  Xn,Xi,T,F
Risk Statements  20/21/22-36/37/38-39/23/24/25-23/24/25-11
Safety Statements  26-36/37-45-16-7
RIDADR  2810
WGK Germany  3
RTECS  QS6350000
F  3-10
HazardClass  6.1
PackingGroup  III
HS Code  29399990
Toxicity LDLo ipr-rat: 6 mg/kg AJEBAK 25,83,47
NFPA 704
1
2 1

3-(2-Pyrrolidinyl)pyridine price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR3063 Nicotine Related Compound F pharmaceutical secondary standard, certified reference material 5746-86-1 50MG $461 2024-03-01 Buy
Sigma-Aldrich N-071 (±)-Nornicotine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? 5746-86-1 1mL $107 2024-03-01 Buy
Sigma-Aldrich 1463371 Nicotine Related Compound F United States Pharmacopeia (USP) Reference Standard 5746-86-1 20mg $1380 2024-03-01 Buy
Alfa Aesar L10809 DL-Nornicotine, 98% 5746-86-1 10mg $69.1 2021-12-16 Buy
Alfa Aesar L10809 DL-Nornicotine, 98% 5746-86-1 50mg $225 2021-12-16 Buy
Product number Packaging Price Buy
PHR3063 50MG $461 Buy
N-071 1mL $107 Buy
1463371 20mg $1380 Buy
L10809 10mg $69.1 Buy
L10809 50mg $225 Buy

3-(2-Pyrrolidinyl)pyridine Chemical Properties,Uses,Production

Description

(±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. The α6 and α7 subunit-containing neuronal nAChRs are particularly responsive to nornicotine with EC50 values of approximately 4 and 17 μM, respectively, when expressed in Xenopus oocytes. Nornicotine promotes cell migration and destabilizes cell-cell junctions in an endothelial cell line. It is generally thought to be free from abuse potential, but it has been self-administered by rats. It can be detected in urine.

Chemical Properties

Colourless Oil

Uses

3-(2-Pyrrolidinyl)pyridine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity. Nicotine USP Related Compound F (3-(pyrrolidine-2-yl)pyridine).

Uses

A metabolite of Nicotine ((N412420). Can catalyze aqueous aldol reactions.

Uses

A metabolite of Nicotine. Can catalyze aqueous aldol reactions

Synthesis Reference(s)

Tetrahedron Letters, 37, p. 1137, 1996 DOI: 10.1016/0040-4039(96)00002-0

Safety Profile

Poison by intraperitoneal route.When heated to decomposition it emits very toxic fumesof NOx and HCl. See also NORNICOTINE

3-(2-Pyrrolidinyl)pyridine synthesis

532-12-7
5746-86-1
Synthesis of 3-(2-Pyrrolidinyl)pyridine from MYOSMINE

3-(2-Pyrrolidinyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

LY-2795050 NORNICOTINE, DL-(RG) (+/-)-NICOTINE

3-(2-Pyrrolidinyl)pyridine Suppliers

Global( 212)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Mujin Biotechnology Co.,Ltd 		+8613288715578 angelia@hbmojin.com China 750 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29730 60
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49732 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29808 58
Shanghai zaiqi biology technology co., ltd 		+86-21-54824098 13817598959 sales@chemzq.com CHINA 136 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244 mike_yan@xuanranglobal.com CHINA 4017 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52849 58
Supplier Advantage
Hebei Mujin Biotechnology Co.,Ltd 		58
Capot Chemical Co.,Ltd. 		60
Hubei xin bonus chemical co. LTD 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
Shanghai zaiqi biology technology co., ltd 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58

View Lastest Price from 3-(2-Pyrrolidinyl)pyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-(2-Pyrrolidinyl)pyridine pictures 2025-03-21 3-(2-Pyrrolidinyl)pyridine
5746-86-1
 US $0.00 / kg 1kg 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
3-(2-Pyrrolidinyl)pyridine pictures 2025-03-06 3-(2-Pyrrolidinyl)pyridine
5746-86-1
 US $0.00 / kg 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-(3-Pyridyl)pyrrolidine, 3-(2-Pyrrolidinyl)pyridine;Nicotine, 1'-demethyl-, (+-)- pictures 2019-12-31 2-(3-Pyridyl)pyrrolidine, 3-(2-Pyrrolidinyl)pyridine;Nicotine, 1'-demethyl-, (+-)-
5746-86-1
 US $1.00 / KG 1KG 99% 200kg Career Henan Chemical Co

5746-86-1(3-(2-Pyrrolidinyl)pyridine)Related Search:

Pyridine Polyvinylpyrrolidone Pyrrolidine Povidone iodine N-Methyl-2-pyrrolidone
N-Vinyl-2-pyrrolidone 3-(Pyrrolidin-2-yl)pyridine hydrochloride 3-(pyrrolidin-2-yl)pyridine dihydrochloride Nicotine (+/-)-COTININE-D3
(-)-COTININE (+/-)-NICOTINE-METHYL-D3 (+)-3-[(2R)-1-Methyl-2-pyrrolidinyl]pyridine,3-[(2R)-1-Methyl-2-pyrrolidinyl]pyridine (+/-)-COTININE-D3 NICOTINE DITARTRATE DIHYDRATE
(S)-3-(1-METHYL-2-PYRROLIDINYL)PYRIDINE, DI-D-TARTRATE,(S)-3-(1-METHYL-2-PYRROLIDINYL)PYRIDINE TARTRATE SALT 4-(2-PYRROLIDINYL)PYRIDINE METHYL-2-PYRROLIDONE

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NORNICOTINE, DL- (+-)-1’-demethylnicotine beta-dl-nornicotine 3-PYRROLIDIN-2-YLPYRIDINE 2-[3-PYRIDYL]PYRROLIDINE 2-[3-PYRIDYL]PYRROLIDONE (+/-)-3-(2-PYRROLIDINYL)PYRIDINE 3-(2-PYRROLIDINYL)PYRIDINE DL-2-(3-Pyridyl)pyrrolidine (+ -)-NORNICOTINE 98+% DL-Nornicotine,96% 2-(3-Pyridyl)pyrrolidine, 3-(2-Pyrrolidinyl)pyridine Nicotine, 1'-demethyl-, (+-)- Pyridine, 3-(2-pyrrolidinyl)-, (+-)- (9ci) (±)-Nornicotine,2-(3-Pyridyl)pyrrolidine, 3-(2-Pyrrolidinyl)pyridine DL-Nornicotine/3-(Pyrrolidin-2-yl)pyridine 2-(3-Pyridinyl)pyrrolidine 2-(Pyridin-3-yl)pyrrolidine (RS)-Nornicotine (1.0 Mg/ML in Methanol) 3-(2-Pyrrolidyl)pyridine (±)-Nornicotine solution Pyridine, 3-(2-pyrrolidinyl)- Nicotine Related Compound F Nicotine USP RC F Nicotine USP Related Compound F (rac-Nicotine EP Impurity F) Nicotine Related Compound F (20 mg) (2S)-2-(3-Pyridinyl)pyrrolidinium (+/-)-nornicotine (R,S)-NORNICOTINE DL-NORNICOTINE (+/-)-Nornicotine, 3-(2-Pyrrolininyl)pyridine 3-[(2S)-pyrrolidin-2-yl]pyridine (nornicotine) Nicotine EP Impurity F as Racemate rac-Nicotine EP Impurity F Sertindole Impurity 20 3-[(2RS)-Pyrrolidin-2-yl]pyridine ((RS)-Nornicotine) (±)-Nornicotine solution (±)-Nornicotine 5746-86-1 AMINE BioChemical Cell Biology Cell Signaling and Neuroscience Ion Channels Ligand-Gated Ion Channels Nicotinic Acetylcholine Receptor Modulators Metabolites & Impurities Aromatics Chiral Reagents Heterocycles Mutagenesis Research Chemicals pharmacetical Nicotine Derivatives Benzenes Heterocycle-Pyridine series Alkaloids