3-(2-Pyrrolidinyl)pyridine
- CAS No.
- 5746-86-1
- Chemical Name:
- 3-(2-Pyrrolidinyl)pyridine
- Synonyms
- DL-NORNICOTINE;(R,S)-NORNICOTINE;NORNICOTINE, DL-;(+/-)-NORNICOTINE;Nicotine USP RC F;(+/-)-nornicotine;DL-Nornicotine,96%;beta-dl-nornicotine;(+ -)-NORNICOTINE 98+%;Sertindole Impurity 20
- CBNumber:
- CB4385206
- Molecular Formula:
- C9H12N2
- Molecular Weight:
- 148.21
- MDL Number:
- MFCD00016913
- MOL File:
- 5746-86-1.mol
Melting point | 235-236 °C(Solv: ethanol (64-17-5)) |
---|---|
Boiling point | 107-108°C 2mm |
Density | 1,074 g/cm3 |
refractive index | 1.54 |
Flash point | 101°C |
storage temp. | 2-8°C |
solubility | H2O: 50 mg/mL |
form | liquid |
pka | 9.09±0.10(Predicted) |
color | yellow |
Specific Gravity | 1.074 |
Water Solubility | Soluble in acetone, chloroform and water (50mg/ml). |
Merck | 14,6712 |
BRN | 81968 |
Stability | Hygroscopic, Light Sensitive, Moisture Sensitive |
CAS DataBase Reference | 5746-86-1(CAS DataBase Reference) |
EWG's Food Scores | 1 |
FDA UNII | 83H6L5QD8Z |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
Hazard Codes | Xn,Xi,T,F | |||||||||
Risk Statements | 20/21/22-36/37/38-39/23/24/25-23/24/25-11 | |||||||||
Safety Statements | 26-36/37-45-16-7 | |||||||||
RIDADR | 2810 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | QS6350000 | |||||||||
F | 3-10 | |||||||||
HazardClass | 6.1 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29399990 | |||||||||
Toxicity | LDLo ipr-rat: 6 mg/kg AJEBAK 25,83,47 | |||||||||
NFPA 704 |
|
3-(2-Pyrrolidinyl)pyridine price More Price(47)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PHR3063 | Nicotine Related Compound F pharmaceutical secondary standard, certified reference material | 5746-86-1 | 50MG | $461 | 2024-03-01 | Buy |
Sigma-Aldrich | N-071 | (±)-Nornicotine solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? | 5746-86-1 | 1mL | $107 | 2024-03-01 | Buy |
Sigma-Aldrich | 1463371 | Nicotine Related Compound F United States Pharmacopeia (USP) Reference Standard | 5746-86-1 | 20mg | $1380 | 2024-03-01 | Buy |
Alfa Aesar | L10809 | DL-Nornicotine, 98% | 5746-86-1 | 10mg | $69.1 | 2021-12-16 | Buy |
Alfa Aesar | L10809 | DL-Nornicotine, 98% | 5746-86-1 | 50mg | $225 | 2021-12-16 | Buy |
3-(2-Pyrrolidinyl)pyridine Chemical Properties,Uses,Production
Description
(±)-Nornicotine is a metabolite of nicotine that acts as a neuronal nicotinic acetylcholine receptor (nAChR) agonist. The α6 and α7 subunit-containing neuronal nAChRs are particularly responsive to nornicotine with EC50 values of approximately 4 and 17 μM, respectively, when expressed in Xenopus oocytes. Nornicotine promotes cell migration and destabilizes cell-cell junctions in an endothelial cell line. It is generally thought to be free from abuse potential, but it has been self-administered by rats. It can be detected in urine.
Chemical Properties
Colourless Oil
Uses
3-(2-Pyrrolidinyl)pyridine is a tobacco alkaloid and the major Nicotine (N412420) metabolite in brain. Nornicotine appears to activate different nAChR subtypes, has a better pharmacokinetic profile, and produces less toxicity than Nicotine. Nornicotine shows a significant analgesic activity. Nicotine USP Related Compound F (3-(pyrrolidine-2-yl)pyridine).
Uses
A metabolite of Nicotine ((N412420). Can catalyze aqueous aldol reactions.
Uses
A metabolite of Nicotine. Can catalyze aqueous aldol reactions
Synthesis Reference(s)
Tetrahedron Letters, 37, p. 1137, 1996 DOI: 10.1016/0040-4039(96)00002-0
Safety Profile
Poison by intraperitoneal route.When heated to decomposition it emits very toxic fumesof NOx and HCl. See also NORNICOTINE
3-(2-Pyrrolidinyl)pyridine Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co.,Ltd | +8613288715578 | angelia@hbmojin.com | China | 968 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9337 | 55 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 | 1015@dideu.com | China | 4088 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
View Lastest Price from 3-(2-Pyrrolidinyl)pyridine manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-14 | 3-(2-Pyrrolidinyl)pyridine
5746-86-1
|
US $0.00 / kg | 1kg | 99% | 50000KG/month | Hebei Mojin Biotechnology Co.,Ltd | |
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2019-12-31 | 2-(3-Pyridyl)pyrrolidine, 3-(2-Pyrrolidinyl)pyridine;Nicotine, 1'-demethyl-, (+-)-
5746-86-1
|
US $1.00 / KG | 1KG | 99% | 200kg | Career Henan Chemical Co |
-
- 3-(2-Pyrrolidinyl)pyridine
5746-86-1
- US $0.00 / kg
- 99%
- Hebei Mojin Biotechnology Co.,Ltd
-
- 2-(3-Pyridyl)pyrrolidine, 3-(2-Pyrrolidinyl)pyridine;Nicotine, 1'-demethyl-, (+-)-
5746-86-1
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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