(+/-)-NICOTINE
- CAS No.
- 22083-74-5
- Chemical Name:
- (+/-)-NICOTINE
- Synonyms
- NICOTINE;(r,s)-nicotine;rac-Nicotine;1-METHYL-2-(3-PYRIDYL)PYRROLIDINE;Nicotine for system suitability CRS;dl-nicotine;(+-)-pyridin;(+-)-nicotin;BLACK LEAF 40;(+/-)-NICOTINE
- CBNumber:
- CB2459639
- Molecular Formula:
- C10H14N2
- Molecular Weight:
- 162.23
- MDL Number:
- MFCD00065370
- MOL File:
- 22083-74-5.mol
| Melting point | -79 °C |
|---|---|
| Boiling point | 67°C/0.5 mm |
| Density | 1.02 g/mL at 25 °C(lit.) |
| Flash point | 101 °C |
| storage temp. | Refrigerator |
| solubility | ethanol: 50 mg/mL |
| pka | 8.02(at 25℃) |
| form | liquid |
| color | yellow |
| optical activity | [α]25/D 0°(lit.) |
| BRN | 82108 |
| Stability | Air Sensitive |
| CAS DataBase Reference | 22083-74-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H310-H411 | |||||||||
| Precautionary statements | P262-P264-P273-P280-P301+P310-P302+P352+P310 | |||||||||
| Hazard Codes | T+,N | |||||||||
| Risk Statements | 25-27-51/53 | |||||||||
| Safety Statements | 36/37-45-61 | |||||||||
| RIDADR | UN 1654 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | QS5257500 | |||||||||
| NFPA 704 |
|
(+/-)-NICOTINE Chemical Properties,Uses,Production
Chemical Properties
(+/-)-NICOTINE is Colourless Liquid
Uses
This is the unnatural isomer of Nicotine
Uses
(+/-)-NICOTINE is an alkaloid isolated from plants. It is an active stimulant, having both addictive and carcinogenic properties.
Uses
Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tra ct and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.
Definition
ChEBI: 3-(1-methylpyrrolidin-2-yl)pyridine is an N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2. It is a N-alkylpyrrolidine, a pyridine alkaloid and a pyrrolidine alkaloid.
Biochem/physiol Actions
Prototype nicotinic acetylcholine receptor agonist.
Purification Methods
(+/-)-NICOTINE is purified by fractional distillation. Its solubility in EtOH is ~5%. The picrate forms yellow needles from hot H2O and has m 219o. The methiodide has m 219o (from MeOH). [Craig J Am Chem Soc 55 2854 1933, Nakane & Hutchinson J Org Chem 43 3922 1978, Beilstein 23/6 V 64.] POISONOUS.
(+/-)-NICOTINE Preparation Products And Raw materials
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