(+/-)-NICOTINE

(+/-)-NICOTINE Basic information

Product Name:	(+/-)-NICOTINE
Synonyms:	BLACK LEAF 40;(+/-)-NICOTINE;3-(1-methyl-2-pyrrolidinyl)-pyridin;3-(1-methyl-pyrrolidin-2-yl)-pyridine;(±)-Nicotine-d7;(+-)-nicotin;(+-)-pyridin;(+)-3-[(2R)-1-Methyl-2-pyrrolidinyl]pyridine
CAS:	22083-74-5
MF:	C10H14N2
MW:	162.23
EINECS:
Product Categories:	AgonistsIon Channels;Cholinergics;Ligand-Gated Ion Channels;Neurotransmitters;Nicotinic Acetylcholine Receptor Modulators;Nicotine Derivatives;Neurochemicals
Mol File:	22083-74-5.mol

(+/-)-NICOTINE Chemical Properties

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

(+/-)-NICOTINE Usage And Synthesis

Chemical Properties	(+/-)-NICOTINE is Colourless Liquid
Uses	This is the unnatural isomer of Nicotine
Uses	(+/-)-NICOTINE is an alkaloid isolated from plants. It is an active stimulant, having both addictive and carcinogenic properties.
Uses	Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tra ct and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.
Definition	ChEBI: 3-(1-methylpyrrolidin-2-yl)pyridine is an N-alkylpyrrolidine that consists of N-methylpyrrolidine bearing a pyridin-3-yl substituent at position 2. It is a N-alkylpyrrolidine, a pyridine alkaloid and a pyrrolidine alkaloid.
Biochem/physiol Actions	Prototype nicotinic acetylcholine receptor agonist.
Purification Methods	(+/-)-NICOTINE is purified by fractional distillation. Its solubility in EtOH is ~5%. The picrate forms yellow needles from hot H2O and has m 219o. The methiodide has m 219o (from MeOH). [Craig J Am Chem Soc 55 2854 1933, Nakane & Hutchinson J Org Chem 43 3922 1978, Beilstein 23/6 V 64.] POISONOUS.

(+/-)-NICOTINE Preparation Products And Raw materials

Raw materials	CALCIUM CARBONATE-->3-(4,5-DIHYDRO-1-METHYL-1H-PYRROL-2-YL)PYRIDINE-->N-METHYLSUCCINIMIDE-->(+)-NICOTINE-(+)-DI-P-TOLUOYL TARTRATE-->(+/-)-Isomyosmine-->3-(2-Pyrrolidinyl)pyridine-->(R,S)-1-METHYL-3-NICOTINOYLPYRROLIDONE-->rac Cotinine-->Nicotine-->3-Pyridyl bromide-->Formic acid-->Iodomethane-->Formaldehyde-->N-Vinyl-2-pyrrolidone
Preparation Products	MYOSMINE

Tag:(+/-)-NICOTINE(22083-74-5) Related Product Information

Nicotinic acid Nicotinamide NICOTINE BI-L-(+)-TARTRATE DL-Nicotine-d3 (methyl-d3),TRIDEUTEROMETHYL-NICOTINE,dl-nicotine-methyl-d3,nicotine-d3(methyl-d3) (-)-NICOTINE D-(+)-HYDROGEN TARTRATE (Nicotine Metabolite) Nicotine (+/-)-COTININE-D3 (+/-)-NICOTINE (-)-COTININE NICOTINE SALICYLATE Nicotine Sulfate (40-45% in Water as Nicotine base) (+)-NICOTINE-(+)-DI-P-TOLUOYL TARTRATE NICOTINE, L-, [N-METHYL-3H] rac trans-4-Cotininecarboxylic Acid NICOTINE, D [N-METHYL 14C] (+)-NICOTINE (+)-DI-P-TOLUOYLTARTRATE SALT NICOTINE, DL-, [N-METHYL-3H]

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