MELITTIN
- CAS No.
- 20449-79-0
- Chemical Name:
- MELITTIN
- Synonyms
- C11198;forapin;forapine;melitten;MELITTIN;MELLITIN;melittini;melittin(major);beevenommelittin;honeybeemelittin
- CBNumber:
- CB4388272
- Molecular Formula:
- C131H229N39O31
- Molecular Weight:
- 2846.46
- MDL Number:
- MFCD00076868
- MOL File:
- 20449-79-0.mol
- MSDS File:
- SDS
alpha | D21 -89.52° (c = 0.409) |
---|---|
Density | 1.39 |
storage temp. | -20°C |
solubility | Soluble to 1 mg/ml in 20% acetonitrile |
form | White to faint tan powder. |
color | White to off-white |
Water Solubility | Soluble to 1 mg/ml in water |
Sequence | H-Gly-Ile-Gly-Ala-Val-Leu-Lys-Val-Leu-Thr-Thr-Gly-Leu-Pro-Ala-Leu-Ile-Ser-Trp-Ile-Lys-Arg-Lys-Arg-Gln-Gln-NH2 |
InChIKey | VDXZNPDIRNWWCW-JFTDCZMZSA-N |
EWG's Food Scores | 1 |
FDA UNII | 24VT8NVE75 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
---|---|
Signal word | Danger |
Hazard statements | H301+H311 |
Precautionary statements | P264-P270-P280-P301+P310-P302+P352+P312-P361+P364 |
Hazard Codes | T |
Risk Statements | 23/24/25 |
Safety Statements | 36-45-36/37/39 |
RIDADR | UN 3462 6.1/PG 1 |
WGK Germany | 3 |
RTECS | OS3965000 |
F | 10-21 |
MELITTIN price More Price(30)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | M4171 | Melittin ≥97% (HPLC), synthetic | 20449-79-0 | 250μg | $511 | 2024-03-01 | Buy |
Sigma-Aldrich | M2272 | Melittin from honey bee venom ≥85% (HPLC) | 20449-79-0 | 1mg | $83.3 | 2024-03-01 | Buy |
Sigma-Aldrich | M2272 | Melittin from honey bee venom ≥85% (HPLC) | 20449-79-0 | 5mg | $280 | 2024-03-01 | Buy |
Cayman Chemical | 17494 | Melittin | 20449-79-0 | 500μg | $107 | 2023-06-20 | Buy |
Cayman Chemical | 17494 | Melittin | 20449-79-0 | 5mg | $796 | 2023-06-20 | Buy |
MELITTIN Chemical Properties,Uses,Production
Uses
Melittin has been used in standard bacterium-killing assay to determine bactericidal activity and study the role of melittin in allergic reactions.
Uses
Melittin from honey bee venom has been used:
- In 3-(4, 5-dimethyl thiazol-2-yl)-2,5diphenyl tetrazolium bromide (MTT) assay to determine its cytotoxicity effect on the growth of human cell lines.
- To study the anti-microbial activity of melittin on the growth of Borrelia burgdorferi in in vitro conditions.
- As a positive control in hemolysis assay and as a cytotoxic agent against HeLa cells.
Definition
ChEBI: A 26-membered polypeptide consisting of Gly, Ile, Gly, Ala, Val, Leu, Lys, Val, Leu, Thr, Thr, Gly, Leu, Pro, Ala, Leu, Ile, Ser, Trp, Ile, Lys, Arg, Lys, Arg, Gln and Gln-NH2 residues joined in sequence. It is the principal active com onent of bee venom.
General Description
Chemical structure: peptide
Biochem/physiol Actions
Melittin acts as an anti-coagulating protein by increasing the time of blood clotting in vitro. Melittin inhibits the activity of S100 calcium-binding protein B (S100B) and plays a vital role in Epilepsy treatment. Melittin retard cathepsin S-induced invasion, proliferation and angiogenesis via inhibition of the vascular endothelial growth factor A (VEGF-A) /VEGF receptor 2 (VEGFR-2)/ mitogen-activated protein kinase 1 (MEK1)/ extracellular signal-regulated kinase 1/2 (ERK1/2) pathway in human MHCC97-H cells (liver cancer cells). Melittin has therapeutic application in various inflammatory diseases such as skin inflammation, neuroinflammation, atherosclerosis, arthritis and liver inflammation. Accumulated melittin degrades phospholipid packing in the cell membrane and causes cell lysis and cell death.
storage
Store at -20°C
MELITTIN Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Henan Bao Enluo International TradeCo.,LTD | +86-17331933971 +86-17331933971 | deasea125996@gmail.com | China | 2503 | 58 |
Shanghai Yunao International Trade Co., Ltd | +8617621705551 | asdf@shanghaihg.cn | China | 265 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10978 | 58 |
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | sales03@chemcn.cn | China | 973 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
Hebei Shengyang Water Conservancy Engineering Co., Ltd. | +8615373025980 | clara@hbshengyang.com | China | 870 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10318 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
View Lastest Price from MELITTIN manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-06-26 | Melittin
20449-79-0
|
US $30.00 / box | 1box | 98% | 2000kg | hebei hongtan Biotechnology Co., Ltd | ||
2024-05-10 | Melittin
20449-79-0
|
US $18.00-18.00 / kg | 1kg | 99.9 | 5000 | Hebei Shengyang Water Conservancy Engineering Co., Ltd. | ||
2024-05-10 | Melittin
20449-79-0
|
US $0.10-0.30 / kg | 1kg | >98% | 20 tons | Zibo Hangyu Biotechnology Development Co., Ltd |
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