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Losartan carboxylic acid

Losartan carboxylic acid structure

CAS No.: 124750-92-1

Chemical Name:: Losartan carboxylic acid

Synonyms: exp3174;Losartan Carboxylic Acid;e-3174;LOSARTAN CARBOXY ACID;EXP 317;l-158641;AKOS 91941;ALSTint-A07;Losartan acid;E-3174, EXP-3174

CBNumber:: CB4399601

Molecular Formula:: C22H21ClN6O2

Molecular Weight:: 436.89

MDL Number:: MFCD00871928

MOL File:: 124750-92-1.mol

MSDS File:: SDS

Last updated:2023-06-30 15:45:59

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Losartan carboxylic acid Properties

Melting point	130-132°C
Boiling point	707.8±70.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	Dimethylformamide, Dimethyl Sulfoxide, Methanol
form	Solid
pka	0.79±0.50(Predicted)
color	Light-Yellow
InChIKey	ZEUXAIYYDDCIRX-UHFFFAOYSA-N
SMILES	C1(CCCC)N(CC2=CC=C(C3=CC=CC=C3C3=NNN=N3)C=C2)C(C(O)=O)=C(Cl)N=1
FDA UNII	GD76OCH73X

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Danger
Hazard statements	H317-H360D-H362
Precautionary statements	P202-P260-P263-P280-P302+P352-P308+P313
Safety Statements	24/25
HS Code	29339900

Losartan carboxylic acid price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	SMB01354	Losartan carboxylic acid ≥95% (HPLC)	124750-92-1	5MG	$75.9	2023-01-07	Buy
Sigma-Aldrich	SMB01354	Losartan carboxylic acid ≥95% (HPLC)	124750-92-1	25MG	$303	2023-01-07	Buy
Cayman Chemical	15957	Losartan Carboxylic Acid ≥98%	124750-92-1	1mg	$37	2024-03-01	Buy
Cayman Chemical	15957	Losartan Carboxylic Acid ≥98%	124750-92-1	5mg	$98	2024-03-01	Buy
Cayman Chemical	15957	Losartan Carboxylic Acid ≥98%	124750-92-1	10mg	$161	2024-03-01	Buy

Product number	Packaging	Price	Buy
SMB01354	5MG	$75.9	Buy
SMB01354	25MG	$303	Buy
15957	1mg	$37	Buy
15957	5mg	$98	Buy
15957	10mg	$161	Buy

Losartan carboxylic acid Chemical Properties,Uses,Production

Description

Losartan carboxylic acid is a physiologically active metabolite of losartan , produced by cytochrome P450 isoforms in the liver. Like the parent compound, losartan carboxylic acid is a potent AT₁ antagonist (K_is = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation. When administered intravenously, losartan carboxylic acid is more potent and has a longer duration of action than losartan. However, the metabolite has very low oral bioavailability. Losartan, but not its metabolite, inhibits platelet aggregation in vitro.

Chemical Properties

Light-Yellow Solid

Uses

Losartan carboxylic acid is used as a metabolite of Losartan.

Definition

ChEBI: A biphenylyltetrazole that is losartan with the hydroxymethyl group at position 5 on the imidazole ring replaced with a carboxylic acid.

in vitro

e-3174 potently blocked the specific binding of [125i]-aii to vsmc isolated from rat aorta. e-3174 was able to dampen the platelet-derived growth factor-induced increase in cell dna synthesis and protein, which led to the blockade of the aii-induced increase in cell protein [1].

in vivo

rats were administrated e-3174 intravenously at a dose of l.0 mg/kg. after 6 hours, e-3174 markedly attenuated the cardiovascular effects of aii in rats. e-3174 induced a progressive fall in mean arterial pressure and a marked increase in renal flow only [2].

storage

Store at -20°C

References

[1]. li, x. & widdop, r. angiotensin type i receptor antagonists cy-11974 and exp 3174 cause selective renal vasodilatation in conscious spontaneously hypertensive rats. clinical science, 1996; 91(2): 147-154.
[2]. sachinidis, a., ko, y., weisser, p., zu bricbkwedde, m., dsing, r., & christian, r. et al. exp3174, a metabolite of losartan (mk954, dup753) is more potent than losartan in blocking the angiotensin ll-induced responses in vascular smooth muscle cells. journal of hypertension. 1993; 11(2): 155-162.

Losartan carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

Losartan Allisartan Isoproxil N-Trityl Losartan Carboxylic Acid

Losartan carboxylic acid Suppliers

Global( 154)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14336	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	9128	58
Hebei Lingding Biotechnology Co., Ltd.	+86-18031140164 +86-19933155420	erin@hbldbiotech.com	China	465	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9626	58
Baoji Guokang Healthchem co.,ltd	+8615604608665 15604608665	dominicguo@gk-bio.com	CHINA	9427	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52861	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10522	58

Supplier	Advantage
Standardpharm Co. Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Shaanxi Dideu Medichem Co. Ltd	58
Hebei Lingding Biotechnology Co., Ltd.	58
Finetech Industry Limited	58
Baoji Guokang Healthchem co.,ltd	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
Zhejiang J&C Biological Technology Co.,Limited	58

View Lastest Price from Losartan carboxylic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2021-10-20	Losartan Carboxylic Acid 124750-92-1	US $100.00 / KG	1KG	99%	9000kg/per week	Hebei Lingding Biotechnology Co., Ltd.
2020-05-10	Losartan Carboxylic Acid 124750-92-1	US $0.00-0.00 / Kg	1KG	99.0%	500 MT	Shaanxi Dideu Medichem Co. Ltd
2020-01-18	2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID 124750-92-1	US $1.00 / KG	1KG	85.0-99.8%	200kgs	Career Henan Chemical Co

Losartan Carboxylic Acid
124750-92-1
US $100.00 / KG
99%
Hebei Lingding Biotechnology Co., Ltd.

Losartan Carboxylic Acid
124750-92-1
US $0.00-0.00 / Kg
99.0%
Shaanxi Dideu Medichem Co. Ltd

2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID
124750-92-1
US $1.00 / KG
85.0-99.8%
Career Henan Chemical Co

124750-92-1(Losartan carboxylic acid)Related Search:

Losartan potassium Ethyl acetate Metoprolol Candesartan cilexetil Valsartan

Irbesartan Losartan Trityl losartan 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]-methyl-1H-imidazole-5-carboxylic acid (LOSARTAN METABOLITE). AKOS 91707

AKOS 91711 Losartan carboxylic acid

1of3

AKOS 91941 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID ’-biphenyl)-4-yl)methyl)- 1h-imidazole-5-carboxylicacid,2-butyl-4-chloro-1-((2’-(14-tetrazol-5-yl)(1,1 1-((2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl)-2-butyl-4-chloro-1H-imidazole-5-carboxylic acid 1H-Imidazole-5-carboxylicacid, 2-butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]- 2-Butyl-4-chloro-1-[[2(1H-tetrazol-5-yl)[1,1biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylicAcid EXP 317 Losartan Carboxylic AcidDiscontinued see product # L470510 l-158641 EXP 3174 (LOSARTAN CARBOXYLIC ACID) 2-Butyl-3-[[2'-(2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]-5-chloro-3H-imidazole-4-carboxylic acid 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-imidazole-5-carboxylic acid 2-Butyl-4-chloro-1-[2'-(1H-tetrazol-5-yl)biphenyl-4-ylmethyl]imidazole-5-carboxylic acid 1H-Imidazole-5-carboxylic acid, 2-butyl-4-chloro-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)- Losartan Carboxylic Acid NEW CATALOGUE NUMBER: see product # L470510 Losartan acid Losartan carboxylic acid, >=98% 2-Butyl-4-chloro-1-[p-(o-1H-tetrazol-5-ylphenyl)benzyl]imidazole-5-formic acid LOSARTAN,2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID Losartan Impurity 14 1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic Acid 2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1 E-3174;EXP-3174;E 3174;EXP 3174;E3174;EXP3174;2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5-YL)[1;1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-CARBOXYLIC ACID Losartan Carboxylic Acid USP/EP/BP 2-BUTYL-4-CHLORO-1-[(2'-(1-H-TETRAZOL-5-YL)[1,1'-BIPHENYL]-4-YL)METHYL]-1-H-IMIDAZOLE-5-CARBOXYLIC ACID USP/EP/BP Losartan Carboxylic Acid (Losartan Carboxylate) Losartan Carboxylic acid Impurity Losartan carboxylic acidQ: What is Losartan carboxylic acid Q: What is the CAS Number of Losartan carboxylic acid Q: What is the storage condition of Losartan carboxylic acid Q: What are the applications of Losartan carboxylic acid 2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid ALSTint-A07 2-n-butyl-5-chloro-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazole-4-carboxylic acid E-3174, EXP-3174 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid E-3174;EXP-3174;E 3174;EXP 3174;E3174;EXP3174 LOSARTAN CARBOXY ACID Losartan Carboxylic Acid e-3174 exp3174 124750-92-1 C22H21ClN6O2 Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Heterocycles