-Defensin-4 (human) (trifluoroacetate salt)
- CAS No.
- 370570-43-7
- Chemical Name:
- -Defensin-4 (human) (trifluoroacetate salt)
- Synonyms
- β-Defensin-4 (human) trifluoroacetate salt;-Defensin-4 (human) (trifluoroacetate salt)
- CBNumber:
- CB44665621
- Molecular Formula:
- C182H296F3N63O54S6
- Molecular Weight:
- 4480.0725496
- MDL Number:
- MOL File:
- 370570-43-7.mol
-Defensin-4 (human) (trifluoroacetate salt) price More Price(1)
-Defensin-4 (human) (trifluoroacetate salt) Chemical Properties,Uses,Production
Description
β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1 It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils.2 β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3 It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-4 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 μg/ml and by rat mast cells in vivo following a 500 ng intradermal dose.4 It also inhibits growth of E. coli, P. aeruginosa, and S. aureus with lethal concentration (LC) values of 5, 12, and 15 μM, respectively, of S. carnosus (MIC = 4.5 μg/ml), and of C. albicans with a minimum fungicidal concentration (MFC) value of 7.5 μM.2,5
References
1. Lehrer, R.I. Primate defensins Nat. Rev. Microbiol. 2(9),727-738(2004).
2. García, J.R., Krause, A., Schulz, S., et al. Human β-
3. Niyonsaba, F., Ushio, H., Nakano, N., et al. Antimicrobial peptides human β-
4. Niyonsaba, F., Ushio, H., Hara, M., et al. Antimicrobial peptides human β-
5. Sharma, H., and Nagaraj, R. Antimicrobial activity of human β-
-Defensin-4 (human) (trifluoroacetate salt) Preparation Products And Raw materials
Raw materials
Preparation Products
-Defensin-4 (human) (trifluoroacetate salt) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |