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-Defensin-4 (human) (trifluoroacetate salt)

-Defensin-4 (human) (trifluoroacetate salt) Structure
-Defensin-4 (human) (trifluoroacetate salt) structure
CAS No.
370570-43-7
Chemical Name:
-Defensin-4 (human) (trifluoroacetate salt)
Synonyms
β-Defensin-4 (human) trifluoroacetate salt;-Defensin-4 (human) (trifluoroacetate salt)
CBNumber:
CB44665621
Molecular Formula:
C182H296F3N63O54S6
Molecular Weight:
4480.0725496
MDL Number:
MOL File:
370570-43-7.mol
Last updated:2023-05-21 10:59:17
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-Defensin-4 (human) (trifluoroacetate salt) Properties

storage temp. Store at -20°C
solubility Water: 1 mg/ml
form A lyophilized powder

-Defensin-4 (human) (trifluoroacetate salt) price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 24579 β-Defensin-4 (human) (trifluoroacetate salt) ≥95% 370570-43-7 100μg $275 2024-03-01 Buy
Product number Packaging Price Buy
24579 100μg $275 Buy

-Defensin-4 (human) (trifluoroacetate salt) Chemical Properties,Uses,Production

Description

β-Defensin-4 is a peptide with antimicrobial properties that protects the skin and mucosal membranes of the respiratory, genitourinary, and gastrointestinal tracts.1 It induces migration of monocytes in vitro when used at a concentration of 10 nM but does not affect migration of neutrophils and eosinophils.2 β-Defensin-4 (30 μg/ml) stimulates gene expression and production of IL-6, IL-10, CXCL10, CCL2, MIP-3α, and RANTES by keratinocytes.3 It also stimulates calcium mobilization, migration, and proliferation of keratinocytes when used at concentrations of 30, 10, and 40 μg/ml, respectively. β-Defensin-4 induces IL-31 production by human peripheral blood-derived mast cells in vitro when used at a concentration of 10 μg/ml and by rat mast cells in vivo following a 500 ng intradermal dose.4 It also inhibits growth of E. coli, P. aeruginosa, and S. aureus with lethal concentration (LC) values of 5, 12, and 15 μM, respectively, of S. carnosus (MIC = 4.5 μg/ml), and of C. albicans with a minimum fungicidal concentration (MFC) value of 7.5 μM.2,5

References

1. Lehrer, R.I. Primate defensins Nat. Rev. Microbiol. 2(9),727-738(2004).
2. García, J.R., Krause, A., Schulz, S., et al. Human β-defensin 4: A novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity FASEB J. 15(10),1819-1821(2001).
3. Niyonsaba, F., Ushio, H., Nakano, N., et al. Antimicrobial peptides human β-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines J. Invest. Dermatol. 127(3),594-604(2007).
4. Niyonsaba, F., Ushio, H., Hara, M., et al. Antimicrobial peptides human β-defensins and cathelicidin LL-37 induce the secretion of a pruritogenic cytokine IL-31 by human mast cells J. Immunol. 184(7),3526-3534(2010).
5. Sharma, H., and Nagaraj, R. Antimicrobial activity of human β-defensin 4 analogs: Insights into the role of disulfide linkages in modulating activity Peptides 38(2),255-265(2012).

-Defensin-4 (human) (trifluoroacetate salt) Preparation Products And Raw materials

Raw materials

Preparation Products

-Defensin-4 (human) (trifluoroacetate salt) Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 28091 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
TargetMol Chemicals Inc. 58
-Defensin-4 (human) (trifluoroacetate salt) β-Defensin-4 (human) trifluoroacetate salt 370570-43-7