(2R,6R)-Hydroxynorketamine
- CAS No.
- 1430202-69-9
- Chemical Name:
- (2R,6R)-Hydroxynorketamine
- Synonyms
- (2R,6R)-Hydroxynorketamine;(2R,6R)-Hydroxynorketamine hydrochloride;(2R,6R)-Hydroxynorketamine hydrochloride >=98% (HPLC);(2R,6R)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride;(2S,6R)-2-amino-3-(2-chlorophenyl)-6-hydroxycyclohexanone hydrochloride;(2R,6R)-2-amino-2-(2-chlorophenyl)-6-hydroxycyclohexan-1-onehydrochloride
- CBNumber:
- CB44668950
- Molecular Formula:
- C12H15Cl2NO2
- Molecular Weight:
- 276.16
- MDL Number:
- MOL File:
- 1430202-69-9.mol
- MSDS File:
- SDS
| storage temp. | 2-8°C |
|---|---|
| solubility | DMF: 5 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 5 mg/ml |
| form | powder |
| color | white to beige |
| optical activity | [α]/D -95 to -115°, c = 1 in H2O |
| FDA UNII | A2F3JNU7UV |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
(2R,6R)-Hydroxynorketamine price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1873 | (2R,6R)-Hydroxynorketamine hydrochloride ≥98% (HPLC) | 1430202-69-9 | 5mg | $131 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1873 | (2R,6R)-Hydroxynorketamine hydrochloride ≥98% (HPLC) | 1430202-69-9 | 25mg | $530 | 2024-03-01 | Buy |
| Cayman Chemical | 19603 | (2R,6R)-Hydroxynorketamine (hydrochloride) | 1430202-69-9 | 1mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 19603 | (2R,6R)-Hydroxynorketamine (hydrochloride) | 1430202-69-9 | 5mg | $404 | 2024-03-01 | Buy |
| Tocris | 6094 | (2R,6R)-Hydroxynorketamine hydrochloride ≥98%(HPLC) | 1430202-69-9 | 10 | $298 | 2021-12-16 | Buy |
(2R,6R)-Hydroxynorketamine Chemical Properties,Uses,Production
Uses
cis-2-Amino-2-(2-chlorophenyl)-6-hydroxycyclohexanone Hydrochloride is a metabolite of ketamine and increase AMPA receptor-mediated excitatory post-synaptic potentials in the CA 1 region of hippocampal slices. Anti-depressive effects.
Biochem/physiol Actions
(2R,6R)-Hydroxynorketamine is a ketamine metabolite that has rapid antidepressant activity without ketamine-related side effects. The NMDAR antagonist (R,S)-ketamine must be metabolized to (2S,6S;2R,6R)-hydroxynorketamine (HNK) to have antidepressant effects. The (2R,6R)-HNK enantiomer appears to be the enantiomer most responsible for antidepressant effects in a mouse study and unlike (2S,6S)-HNK, (2R,6R)-HNK caused no significant changes in locomotion or coordination. (2R,6R)-HNK does not seem to have the same addiction potential as ketamine, since mice did not self-administer pharmacologically relevant doses of (2R,6R)-HNK under the same conditions where ketamine was readily self-administered. The (2R,6R)-HNK antidepressant appears to involve activation of AMPA glutamate receptors rather than inhibition of NMDA glutamate receptors.
storage
Store at RT
(2R,6R)-Hydroxynorketamine Preparation Products And Raw materials
Raw materials
Preparation Products
(2R,6R)-Hydroxynorketamine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19105 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Zhengzhou Akem Chemical Co., Ltd | 13303867194 | 3001317055@qq.com | China | 9625 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 18621169109 | market03@meryer.com | China | 27996 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 13417589054 | trendseenbio@gmail.com | China | 8941 | 58 |
| Shureli Biopharma Co.,Ltd | 0871-68355600 18787766125 | 756338076@qq.com | China | 570 | 58 |
| Shanghai Haozhu Pharmaceutical Technology Co. , Ltd. | 18912729622 | 66161984@qq.com | China | 779 | 58 |