ChemicalBook >> CAS DataBase List >>Verubecestat Trifluoroacetate
Verubecestat Trifluoroacetate
- CAS No.
- 2095432-65-6
- Chemical Name:
- Verubecestat Trifluoroacetate
- Synonyms
- Verubecestat (TFA);Verubecestat Trifluoroacetate;(R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide 2,2,2-trifluoroacetate
- CBNumber:
- CB44672249
- Molecular Formula:
- C19H18F5N5O5S
- Molecular Weight:
- 523.44
- MDL Number:
- MOL File:
- 2095432-65-6.mol
Last updated:2023-05-18 11:31:19
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Verubecestat Trifluoroacetate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Ambeed | A246701 | (R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide2,2,2-trifluoroacetate 95% | 2095432-65-6 | 100mg | $121 | 2021-12-16 | Buy |
| Ambeed | A246701 | (R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide2,2,2-trifluoroacetate 95% | 2095432-65-6 | 250mg | $241 | 2021-12-16 | Buy |
| Ambeed | A246701 | (R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide2,2,2-trifluoroacetate 95% | 2095432-65-6 | 1g | $603 | 2021-12-16 | Buy |
Verubecestat Trifluoroacetate Chemical Properties,Uses,Production
Biological Activity
Verubecestat (MK-8931) Trifluoroacetat is a potent and selective beta-secretase inhibitor, a BACE1 inhibitor.
in vitro
Verubecestat(MK-8931) effectively reduces Aβ40 in cells, Ki：7.8 nM and IC50 ：13 nM.
in vivo
single oral dose of Verubecestat (MK-8931) to rats and cynomolgus monkeys significantly reduced cerebrospinal fluid (CSF) and cortical Aβ40. MK-8931 has an in vivo half-life of 20 hours, and is suitable for a once-daily dosing frequency.
target
| Target | Value |
| BACE2 (Cell-free assay) | 0.37 nM(Ki) |
| BACE1 (Cell-free assay) | 1.75 nM(Ki) |
Verubecestat Trifluoroacetate Preparation Products And Raw materials
Raw materials
Preparation Products
Verubecestat Trifluoroacetate Suppliers
Global( 14)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66099280 17798518460 | cfzhang@aikonchem.com | China | 19918 | 55 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
| Nantong Hi-Future Biotechnology Co., Ltd | 18051384581 | sales@chemhifuture.com | China | 3058 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 63720 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6755 | 58 |
| Bide Pharmatech Ltd. | 400-6005915 | sales@picasso-e.com | China | 39668 | 58 |
| Henan Alpha Chemical Co., Ltd. | 0371-55013243 15324716602 | 2853979810@qq.com | China | 10010 | 58 |
(R)-5-Fluoro-N-(4-fluoro-3-(3-imino-2,5-dimethyl-1,1-dioxido-1,2,4-thiadiazinan-5-yl)phenyl)picolinamide 2,2,2-trifluoroacetate
Verubecestat (TFA)
Verubecestat Trifluoroacetate
2095432-65-6