ChemicalBook >> CAS DataBase List >>1,2-Cyclobutanedicarboxylic acid, 3,4-diphenyl-, 1,2-bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] ester, (1R,2S,3R,4S)-
1,2-Cyclobutanedicarboxylic acid, 3,4-diphenyl-, 1,2-bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] ester, (1R,2S,3R,4S)-
- CAS No.
- 490-15-3
- Chemical Name:
- 1,2-Cyclobutanedicarboxylic acid, 3,4-diphenyl-, 1,2-bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] ester, (1R,2S,3R,4S)-
- Synonyms
- β-Truxilline;Diclazuril Impurity?1 (Diclazuril EP Impurity?A);bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl](1r,2c,3t,4t)-3,4-diphenylcyclobutane-1,2-dicarboxylate(β-truxilline);1,2-Cyclobutanedicarboxylic acid, 3,4-diphenyl-, 1,2-bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] ester, (1R,2S,3R,4S)-
- CBNumber:
- CB44833156
- Molecular Formula:
- C38H46N2O8
- Molecular Weight:
- 658.78
- MDL Number:
- MOL File:
- 490-15-3.mol
Last updated:2023-05-15 10:43:18
1,2-Cyclobutanedicarboxylic acid, 3,4-diphenyl-, 1,2-bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] ester, (1R,2S,3R,4S)- Properties
Melting point | Decomposes at 120°C |
---|---|
Density | 1.29±0.1 g/cm3(Predicted) |
pka | 9.09±0.60(Predicted) |
FDA UNII | X4WN4Y5R5N |
1,2-Cyclobutanedicarboxylic acid, 3,4-diphenyl-, 1,2-bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] ester, (1R,2S,3R,4S)- Chemical Properties,Uses,Production
Description
This isomeric alkaloid from the leaf extract of Erythroxylon truxillense Rusby sinters at 45°C and decomposes above 120°C. It is laevorotatory with [α]D - 29.3°. On acid hydrolysis it yields MeOH, (-)-ecgonine and {3-truxillic acid, m.p. 206°C and may be synthesized in a similar manner to the preceding base.
Uses
β-Truxilline is an alkaloid found in coca leaves. It is an impurity of illicit Cocaine (C633500), which inhibits the dopamine, norepinephrine, and serotonin transporters.
References
Hesse., Pharm. Zeit., 407,668 (1887)
Liebermann., Ber., 21,2342 (1888)
Hesse., ibid, 22,665 (1889)
Liebermann, Drory., ibid, 22,682 (1889)
1,2-Cyclobutanedicarboxylic acid, 3,4-diphenyl-, 1,2-bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] ester, (1R,2S,3R,4S)- Preparation Products And Raw materials
Raw materials
Preparation Products
1,2-Cyclobutanedicarboxylic acid, 3,4-diphenyl-, 1,2-bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] ester, (1R,2S,3R,4S)- Suppliers
Global( 1)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Zhuhai Anzhe Biotechnology Co,Ltd. | 13169972583 | 513211116@qq.com | China | 3015 | 58 |
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Zhuhai Anzhe Biotechnology Co,Ltd. | 58 |
1,2-Cyclobutanedicarboxylic acid, 3,4-diphenyl-, 1,2-bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl] ester, (1R,2S,3R,4S)-
β-Truxilline
bis[(1R,2R,3S,5S)-2-(methoxycarbonyl)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl](1r,2c,3t,4t)-3,4-diphenylcyclobutane-1,2-dicarboxylate(β-truxilline)
Diclazuril Impurity?1 (Diclazuril EP Impurity?A)
490-15-3