4-Nitro-3-trifluoromethyl aniline
- CAS No.
- 393-11-3
- Chemical Name:
- 4-Nitro-3-trifluoromethyl aniline
- Synonyms
- FLU-1;4-Nitro-α,α,α;TIMTEC-BB SBB006652;Flutamide Impurity A;Nilutamide Impurity 3;Nilutamide impurity B CRS;FlutaMide Related CoMpound A;2-Nitro-5-aminobenzotriluoride;5-AMINO-2-NITROBENZOTRIFLUORIDE;3-AMINO-6-NITROBENZOTRIFLUORIDE
- CBNumber:
- CB4483928
- Molecular Formula:
- C7H5F3N2O2
- Molecular Weight:
- 206.12
- MDL Number:
- MFCD00014717
- MOL File:
- 393-11-3.mol
- MSDS File:
- SDS
Melting point | 125-129 °C (lit.) |
---|---|
Boiling point | 326.4±42.0 °C(Predicted) |
Density | 1.4711 (estimate) |
storage temp. | 2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | -0.22±0.10(Predicted) |
color | Yellow to Orange-Yellow |
BRN | 2650702 |
InChIKey | UTKUVRNVYFTEHF-UHFFFAOYSA-N |
CAS DataBase Reference | 393-11-3(CAS DataBase Reference) |
FDA UNII | 15YY91105I |
NIST Chemistry Reference | 5-Amino-2-nitrobenzotrifluoride(393-11-3) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
Hazard Codes | Xi,Xn | |||||||||
Risk Statements | 36/37/38-20/21/22 | |||||||||
Safety Statements | 26-36-36/37 | |||||||||
WGK Germany | 2 | |||||||||
Hazard Note | Irritant | |||||||||
HS Code | 29214200 | |||||||||
NFPA 704 |
|
4-Nitro-3-trifluoromethyl aniline price More Price(28)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | A68807 | 4-Nitro-3-(trifluoromethyl)aniline 98% | 393-11-3 | 5g | $57.6 | 2024-03-01 | Buy |
Sigma-Aldrich | 1285997 | Flutamide Related Compound A United States Pharmacopeia (USP) Reference Standard | 393-11-3 | 20mg | $1300 | 2024-03-01 | Buy |
TCI Chemical | A0377 | 5-Amino-2-nitrobenzotrifluoride >98.0%(GC) | 393-11-3 | 5g | $18 | 2024-03-01 | Buy |
TCI Chemical | A0377 | 5-Amino-2-nitrobenzotrifluoride >98.0%(GC) | 393-11-3 | 25g | $60 | 2024-03-01 | Buy |
Alfa Aesar | A13798 | 4-Nitro-3-(trifluoromethyl)aniline, 98% | 393-11-3 | 1g | $31.65 | 2024-03-01 | Buy |
4-Nitro-3-trifluoromethyl aniline Chemical Properties,Uses,Production
Description
4-Nitro-3-trifluoromethyl aniline is an organic intermediate, which can be used to prepare 4-bromo-2-nitrotrifluorotoluene, an intermediate of medicine and optical waveguide materials, and flutamide, a non steroidal anti androgen drug.
Chemical Properties
Orange to Brown to Dark red powder to crystal.
Uses
4-Nitro-3-(trifluoromethyl)aniline is a metabolite of Flutamide (F598850) (FLU-1 or M2).
Uses
A metabolite of Flutamide (FLU-1 or M2).
Synthesis
The
thiazolium salt 3 (3.30 mg, 0.0122 mmol) was added to a solution of
1-azido-4-nitrobenzene (0.122 mmol) and t-BuOH (18.0 mg, 0.244 mmol) in
degassed THF (0.50 mL) under argon at r.t. The resulting suspension was
stirred for 5 min, and then NaOt-Bu (23.4 mg, 0.244 mmol) was added in
one portion, and the mixture was stirred (Table 2). Water (2 mL) was
added, and the products were extracted with EtOAc (2 ?á 2 mL), the
combined organic phase was dried over anhyd MgSO4, filtered,
and concentrated in vacuo. Purification was achieved by passing the
resulting residue through a short pad of silica (eluting with 50% light
PE-EtOAc) unless otherwise stated.
4-Nitro-3-trifluoromethyl aniline, Time: 12 h, Pale yellow
solid (21.0 mg, 84%). (70:30 petrol-EtOAc) 0.5; mp 90-93 ??C (lit.,
92-93 ??C); IR (FTIR, CHCl3) |ímax cm-1: 3535 (NH2), 3434 (NH2), 1635, 1592 (NO2), 1520 (NO2), 1119; 1H NMR (400 MHz, DMSO-6) 8.59 (d, = 2.7 Hz, 1H), 8.55 (dd, = 9.3, 2.7 Hz, 1H), 7.55 (br s, 2H), 7.32 (d, = 9.3 Hz, 1H); 13C NMR (100 MHz, DMSO-6) 151.8 (C), 135.0 (C), 128.7 (CH), 123.7 (J = 5.9 Hz, F3N2NaO2 [M+Na]+, 229.0195; found, 229.0195.
Fig. The synthetic of 4-Nitro-3-trifluoromethyl aniline
4-Nitro-3-trifluoromethyl aniline Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12450 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5828 | 58 |
Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 | linda@zhongda-biotech.com | China | 204 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29894 | 58 |
Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4242 | 58 |
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10312 | 58 |
Related articles
- Synthesis and application of 4-Nitro-3-trifluoromethyl aniline
- 4-Nitro-3-trifluoromethyl aniline can be used to prepare non steroidal antiandrogenic drug flutamide.
- Oct 13,2022
View Lastest Price from 4-Nitro-3-trifluoromethyl aniline manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-08-24 | 4-Nitro-3-trifluoromethyl aniline
393-11-3
|
US $7.00-123.00 / g | 1g | 99% | 100kg | Wuhan Cell Pharmaceutical Co., Ltd | ||
2024-08-23 | 4-Nitro-3-trifluoromethyl aniline
393-11-3
|
US $10.00 / kg | 1kg | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD | ||
2023-11-09 | 4-Nitro-3-trifluoromethyl aniline
393-11-3
|
US $600.00 / g | 1g | 98% | 10tons | qingdao future trading Co., Ltd |
- 4-Nitro-3-trifluoromethyl aniline
393-11-3
- US $7.00-123.00 / g
- 99%
- Wuhan Cell Pharmaceutical Co., Ltd
- 4-Nitro-3-trifluoromethyl aniline
393-11-3
- US $10.00 / kg
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
- 4-Nitro-3-trifluoromethyl aniline
393-11-3
- US $600.00 / g
- 98%
- qingdao future trading Co., Ltd