4-Nitro-3-trifluoromethyl aniline
- CAS No.
- 393-11-3
- Chemical Name:
- 4-Nitro-3-trifluoromethyl aniline
- Synonyms
- FLU-1;4-Nitro-α,α,α;TIMTEC-BB SBB006652;Flutamide Impurity A;Nilutamide Impurity 3;Nilutamide impurity B CRS;FlutaMide Related CoMpound A;Linagliptin Impurity CD10103;2-Nitro-5-aminobenzotriluoride;5-AMINO-2-NITROBENZOTRIFLUORIDE
- CBNumber:
- CB4483928
- Molecular Formula:
- C7H5F3N2O2
- Molecular Weight:
- 206.12
- MDL Number:
- MFCD00014717
- MOL File:
- 393-11-3.mol
- MSDS File:
- SDS
| Melting point | 125-129 °C (lit.) |
|---|---|
| Boiling point | 326.4±42.0 °C(Predicted) |
| Density | 1.4711 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | -0.22±0.10(Predicted) |
| color | Yellow to Orange-Yellow |
| BRN | 2650702 |
| InChIKey | UTKUVRNVYFTEHF-UHFFFAOYSA-N |
| CAS DataBase Reference | 393-11-3(CAS DataBase Reference) |
| FDA UNII | 15YY91105I |
| NIST Chemistry Reference | 5-Amino-2-nitrobenzotrifluoride(393-11-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36-36/37 | |||||||||
| WGK Germany | 2 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 29214200 | |||||||||
| NFPA 704 |
|
4-Nitro-3-trifluoromethyl aniline price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A68807 | 4-Nitro-3-(trifluoromethyl)aniline 98% | 393-11-3 | 5g | $57.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1285997 | Flutamide Related Compound A United States Pharmacopeia (USP) Reference Standard | 393-11-3 | 20mg | $1300 | 2024-03-01 | Buy |
| TCI Chemical | A0377 | 5-Amino-2-nitrobenzotrifluoride >98.0%(GC) | 393-11-3 | 5g | $18 | 2024-03-01 | Buy |
| TCI Chemical | A0377 | 5-Amino-2-nitrobenzotrifluoride >98.0%(GC) | 393-11-3 | 25g | $60 | 2024-03-01 | Buy |
| Alfa Aesar | A13798 | 4-Nitro-3-(trifluoromethyl)aniline, 98% | 393-11-3 | 1g | $31.65 | 2024-03-01 | Buy |
4-Nitro-3-trifluoromethyl aniline Chemical Properties,Uses,Production
Description
4-Nitro-3-trifluoromethyl aniline is an organic intermediate, which can be used to prepare 4-bromo-2-nitrotrifluorotoluene, an intermediate of medicine and optical waveguide materials, and flutamide, a non steroidal anti androgen drug.
Chemical Properties
Orange to Brown to Dark red powder to crystal.
Uses
4-Nitro-3-(trifluoromethyl)aniline is a metabolite of Flutamide (F598850) (FLU-1 or M2).
Uses
A metabolite of Flutamide (FLU-1 or M2).
Synthesis
The
thiazolium salt 3 (3.30 mg, 0.0122 mmol) was added to a solution of
1-azido-4-nitrobenzene (0.122 mmol) and t-BuOH (18.0 mg, 0.244 mmol) in
degassed THF (0.50 mL) under argon at r.t. The resulting suspension was
stirred for 5 min, and then NaOt-Bu (23.4 mg, 0.244 mmol) was added in
one portion, and the mixture was stirred (Table 2). Water (2 mL) was
added, and the products were extracted with EtOAc (2 ?á 2 mL), the
combined organic phase was dried over anhyd MgSO4, filtered,
and concentrated in vacuo. Purification was achieved by passing the
resulting residue through a short pad of silica (eluting with 50% light
PE-EtOAc) unless otherwise stated.
4-Nitro-3-trifluoromethyl aniline, Time: 12 h, Pale yellow
solid (21.0 mg, 84%). (70:30 petrol-EtOAc) 0.5; mp 90-93 ??C (lit.,
92-93 ??C); IR (FTIR, CHCl3) |ímax cm-1: 3535 (NH2), 3434 (NH2), 1635, 1592 (NO2), 1520 (NO2), 1119; 1H NMR (400 MHz, DMSO-6) 8.59 (d, = 2.7 Hz, 1H), 8.55 (dd, = 9.3, 2.7 Hz, 1H), 7.55 (br s, 2H), 7.32 (d, = 9.3 Hz, 1H); 13C NMR (100 MHz, DMSO-6) 151.8 (C), 135.0 (C), 128.7 (CH), 123.7 (J = 5.9 Hz, F3N2NaO2 [M+Na]+, 229.0195; found, 229.0195.
Fig. The synthetic of 4-Nitro-3-trifluoromethyl aniline
4-Nitro-3-trifluoromethyl aniline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8808 | 58 |
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12834 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| Anhui Zhongda Biotechnology Co., Ltd | +8615689548120 | linda@zhongda-biotech.com | China | 193 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9087 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29880 | 58 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
Related articles
- Synthesis and application of 4-Nitro-3-trifluoromethyl aniline
- 4-Nitro-3-trifluoromethyl aniline can be used to prepare non steroidal antiandrogenic drug flutamide.
- Oct 13，2022
View Lastest Price from 4-Nitro-3-trifluoromethyl aniline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | 4-Nitro-3-trifluoromethyl aniline
393-11-3
|
US $201.00 / mg | 99.68% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-05 | 4-Nitro-3-trifluoromethyl aniline
393-11-3
|
US $0.00-0.00 / KG | 50mg | 99%HPLC | 2000tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2024-10-30 | 4-NITRO-3-TRIFLUOROMETHYL ANILINE
393-11-3
|
US $10.00 / kg | 1kg | 99% | 100 | Hebei Weibang Biotechnology Co., Ltd |
-
- 4-Nitro-3-trifluoromethyl aniline
393-11-3
- US $201.00 / mg
- 99.68%
- TargetMol Chemicals Inc.
-
- 4-Nitro-3-trifluoromethyl aniline
393-11-3
- US $0.00-0.00 / KG
- 99%HPLC
- Shaanxi Dideu Medichem Co. Ltd
-
- 4-NITRO-3-TRIFLUOROMETHYL ANILINE
393-11-3
- US $10.00 / kg
- 99%
- Hebei Weibang Biotechnology Co., Ltd