L-Lysine
- CAS No.
- 56-87-1
- Chemical Name:
- L-Lysine
- Synonyms
- LYSINE;Lys;H-LYS-OH;L-LYSINE BASE;(S)-2,6-Diaminohexanoic acid;2,6-Diaminohexanoic acid;laiansuan;L-Lys-OH;Lysine acid;l-lysine solution
- CBNumber:
- CB4492106
- Molecular Formula:
- C6H14N2O2
- Molecular Weight:
- 146.19
- MDL Number:
- MFCD00064433
- MOL File:
- 56-87-1.mol
- MSDS File:
- SDS
| Melting point | 215 °C (dec.)(lit.) |
|---|---|
| alpha | D20 +14.6° (c = 6.5); D23 +25.9° (c = 2 in 6.0N HCl) |
| Boiling point | 265.81°C (rough estimate) |
| Density | 1.1360 (rough estimate) |
| FEMA | 3847 | L-LYSINE |
| refractive index | 26 ° (C=2, 5mol/L HCl) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | H2O: 0.1 g/mL, clear, colorless |
| form | Powder or Crystals |
| pka | 2.16(at 25℃) |
| color | White to light yellow |
| PH | 9.74 |
| Odor | odorless |
| optical activity | [α]20/D +26.0±1.0°, c = 2% in 6 M HCl |
| Water Solubility | Soluble in water. Insoluble in ethanol, ethyl ether, acetone, benzene and common neutral solvent. |
| Merck | 14,5636 |
| JECFA Number | 1439 |
| BRN | 1722531 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | KDXKERNSBIXSRK-YFKPBYRVSA-N |
| LogP | -3.05 |
| Substances Added to Food (formerly EAFUS) | L-LYSINE |
| FDA 21 CFR | 172.320; 310.545 |
| CAS DataBase Reference | 56-87-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | K3Z4F929H6 |
| NCI Drug Dictionary | L-lysine |
| ATC code | B05XB03 |
| NIST Chemistry Reference | Lysine(56-87-1) |
| EPA Substance Registry System | Lysine (56-87-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| Hazard Codes | Xi |
| Safety Statements | 24/25 |
| WGK Germany | 3 |
| RTECS | OL5540000 |
| TSCA | Yes |
| HS Code | 29224110 |
L-Lysine price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | W384720 | L-Lysine ≥98%, FG | 56-87-1 | 100g | $161 | 2024-03-01 | Buy |
| Sigma-Aldrich | W384720 | L-Lysine ≥98%, FG | 56-87-1 | 1kg | $969 | 2024-03-01 | Buy |
| Sigma-Aldrich | W384720 | L-Lysine ≥98%, FG | 56-87-1 | 5kg | $4310 | 2024-03-01 | Buy |
| Sigma-Aldrich | 62840 | L-Lysine crystallized, ≥98.0% (NT) | 56-87-1 | 25g | $129 | 2024-03-01 | Buy |
| Sigma-Aldrich | 62840 | L-Lysine crystallized, ≥98.0% (NT) | 56-87-1 | 100g | $202 | 2024-03-01 | Buy |
L-Lysine Chemical Properties,Uses,Production
Description
See ι-LYSINE MONOCHLORIDE.
Chemical Properties
L-Lysine is an essential amino acid (a protein building block) that cannot be produced by the body from other nutri ents. It helps ensure adequate absorption of calcium and the formation of collagen for bone, cartilage and connective tissue. This compound is odorless.
Chemical Properties
White to pale yellow crystalline powder
Occurrence
Some natural food sources for l-lysine include lima beans, kidney beans, potatoes, corn, red meat, fish and milk.
Uses
lysine is a skin-conditioning amino acid.
Uses
Essential amino acid for human development. Lysine residues are useful in many cellular processes, due to their ability to accept a wide variety of post-translational modifications.
Uses
A moderate serotonin antagonist and essential amino acid.
Uses
L-Lysine is an essential amino acid used in human nutrition. It plays a vital role in calcium absorption, building muscle protein and recovering from surgery or sports injuries. It is used for the treatment of herpes infections and cold sores. Its derivatives lysine acetylsalicylate is utilized to treat pain as well as to detoxify the body after heroin use. It is an important additive to animal feed. Further, it is used in many foods, especially red meats, fish and dairy products.
Preparation
Produced by fermentation. Also produced by use of continuous ion exchange technology.
Definition
ChEBI: An L-alpha-amino acid; the L-isomer of lysine.
Biotechnological Production
C. glutamicum and, to a lesser extent, E. coli are the main organisms used today
for industrial L-lysine production. The first L-producing strains based on C. glutamicum
were reported in 1961, and those based on E. coli in 1995. The
advantages of using E. coli versus C. glutamicum include the achievement of
higher growth rates at higher fermentation temperatures. The formation of lysine
is highly influenced by two enzymes, aspartate kinase (AK) and homoserine
dehydrogenase (HDH). AK converts aspartate into aspartate semialdehyde, and is highly feedback-inhibited by lysine and threonine. HDH converts aspartate semialdehyde
into homoserine, which is an intermediate for the biosynthesis of threonine,
methionine, and isoleucine. L-Lysine–producing strains therefore often
contain a deregulated AK and/or a reduced activity HDH. Despite the
improvement of the flux from aspartate towards lysine, the availability of key
metabolites from the central metabolic pathways is also essential. Here the formation
of oxaloacetate directly from phosphoenol pyruvate or via pyruvate is
essential for the carbon yield as some unnecessary cycles are included. For
example, inactivation of the enzyme phosphoenol pyruvate carboxykinase, which
catalyzes the reverse reaction from oxaloacetate to phosphoenol pyruvate gave an
improvement in lysine formation. By overexpression of pyruvate carboxylase,
the conversion yield of glucose to lysine could be increased by 50 %. With a
synthetic lysine hyperproducing strain, containing 12 defined modifications from
the wild type, a carbon yield of 0.55 g/g and a product titer of 120 g/L over 30 h
fermentation could be obtained.
Today, however, the main commercial process for L-lysine remains the fermentation
of C. glutamicum. This is performed in fed-batch mode in large-scale
fermenters of up to 500 m3 volume, with production capacities in excess of
100,000 tonnes. The commercial manufacturing process has been comprehensively
described by Pfefferle.
Aroma threshold values
Detection: 500 ppm
Synthesis Reference(s)
Journal of the American Chemical Society, 71, p. 3161, 1949 DOI: 10.1021/ja01177a063
General Description
L-Lysine is a basic amino acid.
Safety Profile
An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Veterinary Drugs and Treatments
Lysine may be effective in suppressing FHV-1 infections in cats.
Purification Methods
Crystallise L-lysine from aqueous EtOH. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2097-2122 1961, Kearley & Ingersoll J Am Chem Soc 73 5783 1951, Beilstein 4 IV 2717.]
L-Lysine Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
1of3
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| DONBOO AMINO ACID COMPANY | +8613063595538 | donboo@donboo.com | China | 9363 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| Yancheng Green Chemicals Co.,Ltd | +undefined-86-25-86655873 | info@royal-chem.com | China | 114 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8812 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81148696 +86-15536356810 | 1022@dideu.com | China | 3882 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 5857 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5978 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18154 | 58 |
| Wuhan Han Sheng New Material Technology Co.，Ltd | +8617798174412 | admin01@hsnm.com.cn | China | 2097 | 58 |
Related articles
- Lysine: Polarity and Application
- Lysine is polar, positively charged and hydrophilic.
- Jan 3，2024
View Lastest Price from L-Lysine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-21 | L-Lysine
56-87-1
|
US $0.00-0.00 / Kg/Bag | 2Kg/Bag | 0.99 | 20 tons | Sinoway Industrial co., ltd. | |
 |
2024-11-21 | L-Lysine
56-87-1
|
US $6.00 / kg | 1kg | 99% | 2000KG/Month | HebeiShuoshengImportandExportco.,Ltd | |
 |
2024-11-21 | L-Lysine
56-87-1
|
US $0.00 / Kg/Drum | 1KG | 98%min | 20 TONS | WUHAN FORTUNA CHEMICAL CO., LTD |