ChemicalBook >> CAS DataBase List >>1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YL]CARBONYL]-2,3,6,7-TETRAHYDROSPIRO[FURO[2,3-F]INDOLE]-3,4'-PIPERIDINE HYDROCHLORIDE

1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YL]CARBONYL]-2,3,6,7-TETRAHYDROSPIRO[FURO[2,3-F]INDOLE]-3,4'-PIPERIDINE HYDROCHLORIDE

1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YL]CARBONYL]-2,3,6,7-TETRAHYDROSPIRO[FURO[2,3-F]INDOLE]-3,4'-PIPERIDINE HYDROCHLORIDE structure

CAS No.: 180083-23-2

Chemical Name:: 1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YL]CARBONYL]-2,3,6,7-TETRAHYDROSPIRO[FURO[2,3-F]INDOLE]-3,4'-PIPERIDINE HYDROCHLORIDE

Synonyms: CS-2436;SB 224289;SB224289HCl;SB 224,289 HYDROCHLORIDE;(2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro;(2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[fu;1Methyl-5-((2methyl-4(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)carbonyl)-2,3,6,7-tetrahydrospiro(furo[2.3-f]ind;6,7-DIHYDRO-1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)[1,1'-BIPHENYL]-4-YL]CARBONYL]-SPIRO[2H-FURO[2,3-F]INDOLE-3(5H) HYDROCHLORIDE;(2'-Methyl-4'-(5-Methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-Methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)Methanone;[2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl](2,5,6,7-tetrahydro-1'-methylspiro[3H-furo[2,3-f]indole-3,4'-piperidin]-5-yl)methanone

CBNumber:: CB4494847

Molecular Formula:: C32H32N4O3

Molecular Weight:: 520.62

MDL Number:: MFCD06407944

MOL File:: 180083-23-2.mol

MSDS File:: SDS

Last updated:2023-05-04 17:34:35

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1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YL]CARBONYL]-2,3,6,7-TETRAHYDROSPIRO[FURO[2,3-F]INDOLE]-3,4'-PIPERIDINE HYDROCHLORIDE Properties

Melting point	>280℃
Boiling point	724.8±70.0 °C(Predicted)
Density	1.34
storage temp.	Store at RT
solubility	DMSO: 4.5 mg/mL
form	solid
pka	9.85±0.20(Predicted)
color	off-white
FDA UNII	F95C648W4N

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3

1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YL]CARBONYL]-2,3,6,7-TETRAHYDROSPIRO[FURO[2,3-F]INDOLE]-3,4'-PIPERIDINE HYDROCHLORIDE price More Price(8)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Tocris	1221	SB224289hydrochloride ≥95%(HPLC)	180083-23-2	50	$899	2021-12-16	Buy
Tocris	1221	SB224289hydrochloride ≥95%(HPLC)	180083-23-2	10	$212	2021-12-16	Buy
TRC	S154610	SB224289	180083-23-2	2.5mg	$775	2021-12-16	Buy
Matrix Scientific	095128	(2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone 95+%	180083-23-2	1g	$4725	2021-12-16	Buy
AK Scientific	9446AA	(2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)methanone	180083-23-2	1g	$6428	2021-12-16	Buy

Product number	Packaging	Price	Buy
1221	50	$899	Buy
1221	10	$212	Buy
S154610	2.5mg	$775	Buy
095128	1g	$4725	Buy
9446AA	1g	$6428	Buy

1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YL]CARBONYL]-2,3,6,7-TETRAHYDROSPIRO[FURO[2,3-F]INDOLE]-3,4'-PIPERIDINE HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

SB 224289A is a 5-HT1B antagonist and a useful compound to examine the role of 5-HT1B receptors in cocaine self-administration and cocaine-seeking behavior (1,2).

Definition

ChEBI: SB 224289 is a member of the class of benzamides obtained by formal condensation of the carboxy group of 2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-carboxylic acid with the secondary amino group of 1'-methyl-6,7-dihydro-5H-spiro[furo[2,3-f]indole-3,4'-piperidine]. Selective 5-HT1B receptor antagonist (pKi = 8.2). Displays >60-fold selectivity over 5-HT1D, 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A and 5-HT2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo. It has a role as a serotonergic antagonist. It is an organic heterotetracyclic compound, an azaspiro compound, a 1,2,4-oxadiazole and a member of benzamides. It is a conjugate base of a SB 224289(1+).

Biological Activity

Selective 5-HT 1B receptor antagonist (pK i = 8.2). Displays > 60-fold selectivity over 5-HT 1D , 5-HT 1A , 5-HT 1E , 5-HT 1F , 5-HT 2A and 5-HT 2C receptors in radioligand binding and functional assays. Centrally active following oral administration in vivo .

1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YL]CARBONYL]-2,3,6,7-TETRAHYDROSPIRO[FURO[2,3-F]INDOLE]-3,4'-PIPERIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YL]CARBONYL]-2,3,6,7-TETRAHYDROSPIRO[FURO[2,3-F]INDOLE]-3,4'-PIPERIDINE HYDROCHLORIDE Suppliers

Global( 27)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43348	58
Shanghai Likang New Materials Co., Limited	+86-16631818819 +86-17736933208	3684455296@qq.com	China	9311	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chengdu NoVi Biotechnology Co., Ltd.	028-81458053	novibiotech@163.com sales@novi-biotech.com	China	226	55
LETOPHARM LIMITED	+86-21-5821 5861	sales@letopharm.com	China	2384	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4182	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60

Supplier	Advantage
TargetMol Chemicals Inc.	58
InvivoChem	58
LEAPCHEM CO., LTD.	58
Shanghai Likang New Materials Co., Limited	58
Amadis Chemical Company Limited	58
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Chengdu NoVi Biotechnology Co., Ltd.	55
LETOPHARM LIMITED	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
EMMX Biotechnology LLC	60

180083-23-2(1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YL]CARBONYL]-2,3,6,7-TETRAHYDROSPIRO[FURO[2,3-F]INDOLE]-3,4'-PIPERIDINE HYDROCHLORIDE)Related Search:

BENZAMIDE, N-(2,5-DIMETHYLPHENYL)-4-METHYL 6-METHYL-2,3-DIHYDRO-1H-INDOLE 4-[(1-METHYL-4-PIPERIDINYL)METHOXY]BENZENAMINE 4-AMINO-2-ISOPROPYL-5-METHYLPHENOL 4-(3-AMINOPHENYL)PIPERIDINE HYDROCHLORIDE

1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YL]CARBONYL]-2,3,6,7-TETRAHYDROSPIRO[FURO[2,3-F]INDOLE]-3,4'-PIPERIDINE HYDROCHLORIDE 6-AMINOTHYMOL HYDROCHLORIDE 2,3-Dihydrobenzo[b]furan-5-ylamine 2-ISOPROPYL-4-AMINO ANISOLE HYDROCHLORIDE (S)-4-(2-METHYL-BUTOXY)-PHENYLAMINE

4-ISOPROPYLPHENETHYLAMINE HYDROCHLORIDE 6-(PIPERIDIN-4-YL)INDOLINE N-METHYLCARVACRYLAMINE Enefexine

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1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-YL]CARBONYL]-2,3,6,7-TETRAHYDROSPIRO[FURO[2,3-F]INDOLE]-3,4'-PIPERIDINE HYDROCHLORIDE 1Methyl-5-((2methyl-4(5-methyl-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)carbonyl)-2,3,6,7-tetrahydrospiro(furo[2.3-f]ind SB224289HCl 6,7-DIHYDRO-1'-METHYL-5-[[2'-METHYL-4'-(5-METHYL-1,2,4-OXADIAZOL-3-YL)[1,1'-BIPHENYL]-4-YL]CARBONYL]-SPIRO[2H-FURO[2,3-F]INDOLE-3(5H) HYDROCHLORIDE SB 224,289 HYDROCHLORIDE [2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl](2,5,6,7-tetrahydro-1'-methylspiro[3H-furo[2,3-f]indole-3,4'-piperidin]-5-yl)methanone SB 224289 (2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro[fu (2'-Methyl-4'-(5-Methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-Methyl-6,7-dihydrospiro[furo[2,3-f]indole-3,4'-piperidin]-5(2H)-yl)Methanone (2'-Methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)-[1,1'-biphenyl]-4-yl)(1'-methyl-6,7-dihydrospiro CS-2436 Methanone, [2'-methyl-4'-(5-methyl-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl](2,5,6,7-tetrahydro-1'-methylspiro[3H-furo[2,3-f]indole-3,4'-piperidin]-5-yl)- 180083-23-2