CITCO
- CAS No.
- 338404-52-7
- Chemical Name:
- CITCO
- Synonyms
- CITCO,Inhibitor,inhibit,Apoptosis;6-(4-Chlorophenyl)imidazo[2,1-b]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl) oxime;Imidazo[2,1-b]thiazole-5-carboxaldehyde, 6-(4-chlorophenyl)-, O-[(3,4-dichlorophenyl)methyl]oxime
- CBNumber:
- CB4497318
- Molecular Formula:
- C19H12Cl3N3OS
- Molecular Weight:
- 436.74
- MDL Number:
- MFCD00139608
- MOL File:
- 338404-52-7.mol
- MSDS File:
- SDS
| Density | 1.48±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | -20°C |
| solubility | DMSO: 28 mg/mL, soluble |
| form | solid |
| pka | 4.05±0.40(Predicted) |
| color | Light yellow to yellow |
| FDA UNII | D77H8321PB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
CITCO price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C6240 | CITCO ≥98% (HPLC), solid | 338404-52-7 | 5mg | $135 | 2024-03-01 | Buy |
| Cayman Chemical | 16027 | CITCO ≥95% | 338404-52-7 | 5mg | $72 | 2024-03-01 | Buy |
| Cayman Chemical | 16027 | CITCO ≥95% | 338404-52-7 | 10mg | $135 | 2024-03-01 | Buy |
| Cayman Chemical | 16027 | CITCO ≥95% | 338404-52-7 | 25mg | $301 | 2024-03-01 | Buy |
| TRC | C433048 | CITCO | 338404-52-7 | 1mg | $75 | 2021-12-16 | Buy |
CITCO Chemical Properties,Uses,Production
Uses
CITCO has been used for the activation of mouse constitutive androstane receptor (CAR) and human CAR.
Definition
ChEBI: 1-[6-(4-chlorophenyl)-5-imidazo[2,1-b]thiazolyl]-N-[(3,4-dichlorophenyl)methoxy]methanimine is a member of imidazoles.
General Description
CITCO is an imidazothiazole derivative. It stimulates human constitutive androstane receptor (CAR) nuclear translocation.
Biological Activity
citco, an imidazothiazole derivative, is a selective agonist of human car, with an ec50 value of 49 nm and > 50-fold selectivity to car over pregnane x receptor (pxr), and no activity on other nuclear receptors. upon activation with specific agonists, car translocates into the nucleus and binds to the response elements as monomers or car/rxr heterodimers. the car functions as a xenobiotic receptor, involved in detoxification and clearance of toxic substances from the liver. in addition, activation with selective car agonists such as citco has also been shown to inhibit growth and expansion of brain tumor stem cells.1. chakraborty s, kanakasabai s, bright jj. constitutive androstane receptor agonist citco inhibits growth and expansion of brain tumour stem cells. british journal of cancer, 2011, 104(3): 448-459.
Biochem/physiol Actions
CITCO is a constitutive androstane receptor (CAR) agonist; nuclear receptor NR113 agonist.
storage
Desiccate at -20°C
CITCO Preparation Products And Raw materials
Raw materials
Preparation Products
CITCO Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3465 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8005 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2976 | 58 |