ERYTHROMYCIN A DIHYDRATE
- CAS No.
- 59319-72-1
- Chemical Name:
- ERYTHROMYCIN A DIHYDRATE
- Synonyms
- Erythromycin A, EvoPure;Roxithromycin Impurity A;ERYTHROMYCIN A, DIHYDRATE VETRANAL;Erythromycin A dihydrateQ: What is Erythromycin A dihydrate Q: What is the CAS Number of Erythromycin A dihydrate Q: What is the storage condition of Erythromycin A dihydrate
- CBNumber:
- CB4502522
- Molecular Formula:
- C37H67NO13.H2O
- Molecular Weight:
- 751.945
- MDL Number:
- MFCD00144254
- MOL File:
- 59319-72-1.mol
Melting point | 197.6 °C |
---|---|
FDA UNII | T0O317A6OW |
ERYTHROMYCIN A DIHYDRATE Chemical Properties,Uses,Production
Biological Activity
Erythromycin dihyrate is a macrolide antibiotic produced by actinomycetes with broad antibacterial activity. It acts by binding to the bacterial 50S ribosomal subunit and inhibits RNA-dependent protein synthesis by blocking transpeptidation and/or translocation reactions without affecting nucleic acid synthesis .
in vitro
Erythromycin dihyrate inhibits growth of P. falciparum with IC 50 and IC 90 values of 58.2 μM and 104.0 μM, respectively .
in vivo
Mice of the ddY strain began to receive Erythromycin dihyrate 7 days after inoculation of EAC cells, and CDF mice begins to receive Erythromycin dihyrate immediately after inoculation of P388 cells. Erythromycin dihyrate (gastric intubation; 0.1-50 mg/ kg; 30-120 days) decreases tumor growth from the dose of 5 mg/kg, mice receiving 1-10 mg/kg of Erythromycin dihyrate survives much longer than control mice, Only 10% of mice treated with 5 mg/kg of Erythromycin dihyrate had no evidence of tumor formation on day 60, and the mice are alive even at 120 days after inoculation. However, treatment with 50 mg/kg of Erythromycin dihyrate shortens mean survival time in tumorbearing mice by 4-5 days when it compares to controls.
Animal Model: | Female ddY mice at the age of 6 weeks with EAC cells or CDF mice at the age of 6 weeks with P388 ce lls |
Dosage: | 0.1 mg/kg; 0.5 mg/kg; 10 mg/kg; 30 mg/kg; 50 mg/kg |
Administration: | Gastric intubation; 30-120 days |
Result: | Decrease tumor growth and prolonged the mean survival time of mice from the dose of 5 mg/kg, however, the 50 mg/kg dosage shortens the MST in tumorbearing mice. |
ERYTHROMYCIN A DIHYDRATE Preparation Products And Raw materials
Raw materials
Preparation Products
ERYTHROMYCIN A DIHYDRATE Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
Hangzhou J&H Chemical Co., Ltd. | 0571-+86-571-87396432 | sales@jhechem.com | China | 11280 | 59 |
Shenzhen SUNGENING Bio-Medical Co., Ltd. | 0755-28967200 13631290199 | wxf@sungening.com | China | 9592 | 60 |
Jinan blalong chemical co. LTD | 2710913286@.com | 1513643261@qq.com | China | 14253 | 58 |
Hubei Moco Chemical Co., Ltd. | 18576690171 | 3001071511@qq.com | China | 10987 | 58 |
Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 12007 | 58 |
59319-72-1(ERYTHROMYCIN A DIHYDRATE)Related Search:
1of3