Amfepramone hydrochloride
- CAS No.
- 134-80-5
- Chemical Name:
- Amfepramone hydrochloride
- Synonyms
- Tenapil;tenuate;Anfamon;Moderatan;tenuate-dospan;regenonhydrochloride;tenuatehydrochloride;amfepramonhydrochloride;Amfepramone Hydrocloride;amfepramone hydrochloride
- CBNumber:
- CB4676232
- Molecular Formula:
- C13H20ClNO
- Molecular Weight:
- 241.76
- MDL Number:
- MFCD00058013
- MOL File:
- 134-80-5.mol
- MSDS File:
- SDS
| Melting point | 180-1810C |
|---|---|
| Flash point | 9℃ |
| storage temp. | Controlled Substance, -20°C Freezer |
| solubility | DMF: 1.25 mg/ml; DMSO: 3 mg/ml; Ethanol: 3 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml |
| form | A crystalline solid |
| FDA UNII | 19V2PL39NG |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02,GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H301+H311+H331-H370 | |||||||||
| Precautionary statements | P210-P233-P280-P301+P310-P303+P361+P353-P304+P340+P311 | |||||||||
| Hazard Codes | F,T | |||||||||
| Risk Statements | 11-23/24/25-39/23/24/25-20/21/22 | |||||||||
| Safety Statements | 7-16-36/37-45-36 | |||||||||
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution | |||||||||
| WGK Germany | 1 | |||||||||
| HS Code | 2922310000 | |||||||||
| NFPA 704 |
|
Amfepramone hydrochloride Chemical Properties,Uses,Production
Chemical Properties
Off-White Solid
Originator
Tenuate,Merrell National ,US,1959
Uses
Controlled substance (stimulant). Anorexic.
Definition
ChEBI: The hydrochloride salt of diethylpropion. A central stimulant and indirect-acting sympathomimetic, it is an appetite depressant and is used as an anoretic in the short term management of obesity.
Manufacturing Process
1,145 g of α-bromopropiophenone and 850 g of diethylamine are combined under stirring and heated on a water bath to boiling. The precipitate is filtered off under suction and washed with benzol. The filtrate is shaken up with aqueous hydrogen chloride, the aqueous solution made alkaline and etherified. The solution freed of the ether is fractionated. The boiling point (6 mm) is 140°C and the yield 800 g. The base is dissolved in acetic ester and precipitated with isopropanolic hydrogen chloride. After suction filtration and washing with ether the yield is found to be 750 g (80%)and the melting point 168°C.
Therapeutic Function
Anorexic
General Description
Because it has two large (relative to H or methyl) N-alkylsubstituents, diethylpropion hydrochloride, 1-phenyl-2-diethylaminopropan-1-one hydrochloride (Tenuate, Tepanil),has fewer sympathomimetic, cardiovascular, and CNSstimulatoryeffects than amphetamine. It is reportedly ananorexiant agent that can be used for the treatment of obesityin patients with hypertension and cardiovascular disease.According to the generalization long used for thisgroup of drugs, increasing N-alkyl size reduces central 1effects and increases β effects, even though the effects arelikely mediated principally by indirect NE release.
Amfepramone hydrochloride Preparation Products And Raw materials
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