ANTI-CASPASE-12
- CAS No.
- Chemical Name:
- ANTI-CASPASE-12
- Synonyms
- ANTI-CASPASE-12;MONOCLONAL ANTI-CASPASE 12;ANTISERUM TO CASPASE-12 (NT);POLYCLONAL ANTIBODY TO CASPASE-12 (NT);Anti-Caspase-12 (small) antibody produced in rabbit;Anti-Caspase-12 (large) antibody produced in rabbit;Monoclonal Anti-Caspase 12 antibody produced in rat
- CBNumber:
- CB4677350
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD03454855
- MOL File:
- Mol file
ANTI-CASPASE-12 price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C7611 | Monoclonal Anti-Caspase 12 antibody produced in rat clone 14F7, purified immunoglobulin, buffered aqueous solution | 0.2mL | $217.6 | 2024-03-01 | Buy | |
| Sigma-Aldrich | PRS3195 | Anti-Caspase-12 (large) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution | 100μG | $503 | 2023-06-20 | Buy |
ANTI-CASPASE-12 Chemical Properties,Uses,Production
Uses
Monoclonal Anti-Caspase 12 has been used in immunoblotting and immunocytochemistry (4% paraformaldehyde-fixed, paraffin-embedded).
General Description
Caspase 12 is a protein that belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The human caspase 12 gene is localized at a single locus within the caspase 1/ICE gene cluster on chromosome 11q22. The functionality is lost in humans and they cannot play a role in Alzheimer′s disease. Caspase-12 is detected in endoplasmic reticulum (ER), plays a role in ER-mediated apoptosis and inflammatory caspase activation pathway.
Biochem/physiol Actions
Murine caspase 12 (CASP12) is activated during endoplasmic reticulum stress and activates other caspases which act on substrates, ultimately leading to apoptosis. The protein has been shown to be activated during progression of retinal degeneration in animal models. In mice models, CASP12 has been shown to cause neuronal death resulting from ischemia/reperfusion. Casp12 might stimulate nuclear factor-κB (NF-κB) by directing the post-translational degradation of inhibitor of kappa B (IκBα). Overexpression of caspase 12 induces apoptosis, which is inhibited by the pan caspase inhibitor carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]- fluoromethyl ketone (z-VAD-FMK).
ANTI-CASPASE-12 Preparation Products And Raw materials
Raw materials
Preparation Products
ANTI-CASPASE-12 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Riedel-de Haen AG | -- | United States | 6825 | 87 | |
| SIGMA-RBI | -- | Switzerland | 6913 | 91 | |
| Kamiya Biomedical Company | -- | ordering@kamiyabiomedical.com | United States | 736 | 72 |
| Fluorochem Ltd. | -- | enquiries@fluorochem.co.uk | United Kingdom | 6406 | 74 |
| BD Biosciences | -- | United States | 5013 | 82 | |
| MP Biomedicals, Inc. | -- | United States | 6566 | 81 |
| Supplier | Advantage |
|---|---|
| Riedel-de Haen AG | 87 |
| SIGMA-RBI | 91 |
| Kamiya Biomedical Company | 72 |
| Fluorochem Ltd. | 74 |
| BD Biosciences | 82 |
| MP Biomedicals, Inc. | 81 |