3-(Trifluoromethyl)phenyl isocyanate
- CAS No.
- 329-01-1
- Chemical Name:
- 3-(Trifluoromethyl)phenyl isocyanate
- Synonyms
- TIC;JAP3;MOP3;BMAL1;PASD3;Sorafenib Impurity 17;isocyanobenzotrifluoride;alpha,alpha,alpha-Trifluo;Sorafenib Impurity 17 CRS;Isocyanatobenzotrifluoride
- CBNumber:
- CB4733591
- Molecular Formula:
- C8H4F3NO
- Molecular Weight:
- 187.12
- MDL Number:
- MFCD00002020
- MOL File:
- 329-01-1.mol
Melting point | -26 °C |
---|---|
Boiling point | 54 °C11 mm Hg(lit.) |
Density | 1.359 g/mL at 25 °C(lit.) |
vapor pressure | 2.44 psi ( 20 °C) |
refractive index |
n |
Flash point | 138 °F |
storage temp. | Keep Cold |
solubility | soluble in Toluene |
form | clear liquid |
color | Colorless to Almost colorless |
Specific Gravity | 1.359 |
Water Solubility | 5.46g/L at 25℃ |
Sensitive | Lachrymatory |
BRN | 744880 |
LogP | 2.04 |
CAS DataBase Reference | 329-01-1(CAS DataBase Reference) |
FDA UNII | QPS7LLZ6XM |
NIST Chemistry Reference | Benzene, 1-isocyanato-3-(trifluoromethyl)-(329-01-1) |
EPA Substance Registry System | 3-Trifluoromethylphenyl isocyanate (329-01-1) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() ![]() GHS02,GHS05,GHS06,GHS09 |
|||||||||
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Signal word | Danger | |||||||||
Hazard statements | H226-H302-H311-H315-H317-H318-H330-H335-H411 | |||||||||
Precautionary statements | P210-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
Hazard Codes | Xn,T,T+ | |||||||||
Risk Statements | 20/22-37/38-42-36/37/38-26-21/22-22 | |||||||||
Safety Statements | 23-28-45-36/37/39-28A-26-36/37-22-9 | |||||||||
RIDADR | UN 3384 6.1/PG 1 | |||||||||
WGK Germany | 2 | |||||||||
RTECS | NR0200000 | |||||||||
F | 10 | |||||||||
Hazard Note | Toxic/Lachrymatory/Keep Cold | |||||||||
TSCA | Yes | |||||||||
HazardClass | 6.1 | |||||||||
PackingGroup | II | |||||||||
HS Code | 29291090 | |||||||||
NFPA 704 |
|
3-(Trifluoromethyl)phenyl isocyanate price More Price(15)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 159387 | 3-(Trifluoromethyl)phenyl isocyanate 97% | 329-01-1 | 5g | $19.36 | 2024-03-01 | Buy |
TCI Chemical | I0340 | 3-(Trifluoromethyl)phenyl Isocyanate >96.0%(GC) | 329-01-1 | 5g | $47 | 2024-03-01 | Buy |
TCI Chemical | I0340 | 3-(Trifluoromethyl)phenyl Isocyanate >96.0%(GC) | 329-01-1 | 25g | $136 | 2024-03-01 | Buy |
Alfa Aesar | L09448 | 3-(Trifluoromethyl)phenyl isocyanate, 98% | 329-01-1 | 1g | $15.65 | 2024-03-01 | Buy |
Alfa Aesar | L09448 | 3-(Trifluoromethyl)phenyl isocyanate, 98% | 329-01-1 | 5g | $45.65 | 2024-03-01 | Buy |
3-(Trifluoromethyl)phenyl isocyanate Chemical Properties,Uses,Production
Synthesis
The preparation method is as follows: adding 3-trifluoromethylaniline and chlorobenzene to the reaction flask, stirring, mixing and dissolving it, cooling to 0-10° C., introducing dry hydrogen chloride to make it saturated, and then adding N,N-diisopropylamine. Butyl chloromethylamide, heated to 50°C and kept for 30min, and then introduced phosgene. After a certain amount of phosgene was introduced, the reaction was completed. Then the material is distilled and desolubilized to obtain the finished product.
Chemical Properties
colorless to light yellow liquid
Uses
3-?(Trifluoromethyl)?phenyl Isocyanate is a reagent used in the synthesis of heme-regulated inhibitor as selective activators of the eukaryotic inhibition factor Alpha (eIF2α) phosphorylation arm of the endoplasmic reticulum stress response. Influences cell proliferation, cell differentiaton and adaptation to stress. Also a reagent in the preparation of sorafenib derivatives.
Flammability and Explosibility
Not classified
Safety Profile
Moderately toxic by ingestion, inhalation, and intraperitoneal routes. A lachrymator. Flammable liquid when exposed to heat, sparks, or flame. When heated to decomposition it emits very toxic fumes of NOx and F-. See also ISOCYANATES and FLUORIDES.
3-(Trifluoromethyl)phenyl isocyanate Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4242 | 58 |
Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2169 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14336 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29825 | 58 |
Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
View Lastest Price from 3-(Trifluoromethyl)phenyl isocyanate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2020-02-01 | 3-(Trifluoromethyl)phenyl isocyanate
329-01-1
|
US $1.00 / KG | 1KG | 99% | 200kgs | Career Henan Chemical Co |
-
- 3-(Trifluoromethyl)phenyl isocyanate
329-01-1
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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