ChemicalBook >> CAS DataBase List >>3-(Trifluoromethyl)phenyl isocyanate
3-(Trifluoromethyl)phenyl isocyanate
- CAS No.
- 329-01-1
- Chemical Name:
- 3-(Trifluoromethyl)phenyl isocyanate
- Synonyms
- TIC;JAP3;MOP3;BMAL1;PASD3;Sorafenib Impurity 17;isocyanobenzotrifluoride;alpha,alpha,alpha-Trifluo;Sorafenib Impurity 17 CRS;Isocyanatobenzotrifluoride
- CBNumber:
- CB4733591
- Molecular Formula:
- C8H4F3NO
- Molecular Weight:
- 187.12
- MDL Number:
- MFCD00002020
- MOL File:
- 329-01-1.mol
Last updated:2023-04-23 13:52:06
| Melting point | -26 °C |
|---|---|
| Boiling point | 54 °C11 mm Hg(lit.) |
| Density | 1.359 g/mL at 25 °C(lit.) |
| vapor pressure | 2.44 psi ( 20 °C) |
| refractive index |
n |
| Flash point | 138 °F |
| storage temp. | Keep Cold |
| solubility | soluble in Toluene |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Specific Gravity | 1.359 |
| Water Solubility | 5.46g/L at 25℃ |
| Sensitive | Lachrymatory |
| BRN | 744880 |
| LogP | 2.04 |
| CAS DataBase Reference | 329-01-1(CAS DataBase Reference) |
| FDA UNII | QPS7LLZ6XM |
| NIST Chemistry Reference | Benzene, 1-isocyanato-3-(trifluoromethyl)-(329-01-1) |
| EPA Substance Registry System | 3-Trifluoromethylphenyl isocyanate (329-01-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS02,GHS05,GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H226-H302-H311-H315-H317-H318-H330-H335-H411 | |||||||||
| Precautionary statements | P210-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,T,T+ | |||||||||
| Risk Statements | 20/22-37/38-42-36/37/38-26-21/22-22 | |||||||||
| Safety Statements | 23-28-45-36/37/39-28A-26-36/37-22-9 | |||||||||
| RIDADR | UN 3384 6.1/PG 1 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | NR0200000 | |||||||||
| F | 10 | |||||||||
| Hazard Note | Toxic/Lachrymatory/Keep Cold | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29291090 | |||||||||
| NFPA 704 |
|
3-(Trifluoromethyl)phenyl isocyanate price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 159387 | 3-(Trifluoromethyl)phenyl isocyanate 97% | 329-01-1 | 5g | $19.36 | 2024-03-01 | Buy |
| TCI Chemical | I0340 | 3-(Trifluoromethyl)phenyl Isocyanate >96.0%(GC) | 329-01-1 | 5g | $47 | 2024-03-01 | Buy |
| TCI Chemical | I0340 | 3-(Trifluoromethyl)phenyl Isocyanate >96.0%(GC) | 329-01-1 | 25g | $136 | 2024-03-01 | Buy |
| Alfa Aesar | L09448 | 3-(Trifluoromethyl)phenyl isocyanate, 98% | 329-01-1 | 1g | $15.65 | 2024-03-01 | Buy |
| Alfa Aesar | L09448 | 3-(Trifluoromethyl)phenyl isocyanate, 98% | 329-01-1 | 5g | $45.65 | 2024-03-01 | Buy |
3-(Trifluoromethyl)phenyl isocyanate Chemical Properties,Uses,Production
Synthesis
The preparation method is as follows: adding 3-trifluoromethylaniline and chlorobenzene to the reaction flask, stirring, mixing and dissolving it, cooling to 0-10° C., introducing dry hydrogen chloride to make it saturated, and then adding N,N-diisopropylamine. Butyl chloromethylamide, heated to 50°C and kept for 30min, and then introduced phosgene. After a certain amount of phosgene was introduced, the reaction was completed. Then the material is distilled and desolubilized to obtain the finished product.
Chemical Properties
colorless to light yellow liquid
Uses
3-?(Trifluoromethyl)?phenyl Isocyanate is a reagent used in the synthesis of heme-regulated inhibitor as selective activators of the eukaryotic inhibition factor Alpha (eIF2α) phosphorylation arm of the endoplasmic reticulum stress response. Influences cell proliferation, cell differentiaton and adaptation to stress. Also a reagent in the preparation of sorafenib derivatives.
Flammability and Explosibility
Not classified
Safety Profile
Moderately toxic by ingestion, inhalation, and intraperitoneal routes. A lachrymator. Flammable liquid when exposed to heat, sparks, or flame. When heated to decomposition it emits very toxic fumes of NOx and F-. See also ISOCYANATES and FLUORIDES.
3-(Trifluoromethyl)phenyl isocyanate Preparation Products And Raw materials
Global( 127)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1803 | 55 |
| Changzhou Ansciep Chemical Co., Ltd. | +86 519 86305871 | sales@ansciepchem.com | CHINA | 4241 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2158 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10032 | 58 |
View Lastest Price from 3-(Trifluoromethyl)phenyl isocyanate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-02-01 | 3-(Trifluoromethyl)phenyl isocyanate
329-01-1
|
US $1.00 / KG | 1KG | 99% | 200kgs | Career Henan Chemical Co |
-
- 3-(Trifluoromethyl)phenyl isocyanate
329-01-1
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
329-01-1(3-(Trifluoromethyl)phenyl isocyanate)Related Search:
4'-(Trifluoromethyl)acetophenone
PHENYL ACETATE
Trityl olmesartan
Phenyl isothiocyanate
PHENYL VALERATE
ISOCYANIC ACID
2-(Trifluoromethyl)benzoic acid
2-(Trifluoromethyl)benzaldehyde
Benzotrifluoride
Isocyanatocyclohexane
1of4
1-isocyanato-3-(trifluoromethyl)-benzen
1-Isocyanato-3-(trifluoromethyl)benzene
3-Trifluoromethylphenylcyanate
alpha,alpha,alpha-Trifluoro-3-tolyl isocyanate
alpha,alpha,alpha-Trifluoro-meta-tolylisocyanate
benzene-1-isocyanato-3-(trifluoromethyl)-
Isocyanic acid m-trifluoromethylphenyl ester
Isocyanic acid, alpha,alpha,alpha-trifluoro-m-tolyl ester
isocyanicacid,(m-trifluoromethylphenyl)ester
isocyanobenzotrifluoride
TIC
3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE
A,A,A-TRIFLUORO-M-TOLYL ISOCYANATE
ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLYL ISOCYANATE
Isocyanatobenzotrifluoride
ISOCYANIC ACID 3-(TRIFLUOROMETHYL)PHENYL ESTER
3-Isocyanatobenzotrifluoride~alpha,alpha,alpha-Trifluoro-m-tolyl isocyanate
3-Isocyanatobenzotrifluoride
Benzotrifluoro-3-isocyanate
à,à,à-trifluoro-m-tolyl isocyanate
3-Trifluormethyl-phenylisocyanat
TRIFLUOROMETHYL PHENYLISOCYANATE
3-trifluromethyl phenyl isocyanate
Isocyanic acid m-trifluoromethylphenyl
alpha,alpha,alpha-Trifluoro-m-tolyl isocyanate,98%
alpha,alpha,alpha-Trifluo
3-(Trifluoromethyl)phenyl isocyanate ,98%
alpha,alpha,alpha-Trifluoro-M-tolyl isocyanate, 98% 5GR
Isocyanic Acid 3-(Trifluoromethyl)phenyl Ester
alpha,alpha,alpha-Trifluoro-m-tolyl Isocyanate
3-Isocyanatobenzotrifluoride, 1-Isocyanato-3-(trifluoromethyl)benzene
M-(TRIFLUOROMETHYL)PHENYL ISOCYANATE
BMAL1
JAP3
MOP3
PASD3
3-(Trifluoromethyl)phenyl isocyate
α，α，α-Trifluoro-m-tolyl isocyanate
3-(Trifluoromethyl)phenyl Isocyanate(See C4X-112420)
3-(Trifluoromethyl)phenylIsocyanate>
Sorafenib Impurity 17
Sorafenib Impurity 17 CRS
329-01-1
Nitrogen Compounds
Isocyanates
Organic Building Blocks
ARYL ISOCYANATE
Building Blocks
Phenyl isocyanate&Phenyl isothiocyanate