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Flumethasone 21-pivalate

CAS No.
2002-29-1
Chemical Name:
Flumethasone 21-pivalate
Synonyms
Losalen;Lorinden;locorten;locacorten;NSC 107680;21-pivalate;FLUMETHSONEPIVALATE;FLUMETHASONE PIVALATE;Flumethasome pivalate;flumetasone 21-pivalate
CBNumber:
CB4762018
Molecular Formula:
C27H36F2O6
Molecular Weight:
494.57
MDL Number:
MFCD00079287
MOL File:
2002-29-1.mol
Last updated:2024-12-18 14:08:52

Flumethasone 21-pivalate Properties

Melting point >263°C (dec.)
Boiling point 600.3±55.0 °C(Predicted)
Density 1.27±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility dioxane: soluble4.0ML, clear, colorless to very faintly yellow (50 mg + 4.0 mL dioxane)
form solid
pka 11.86±0.70(Predicted)
color White to Off-White
optical activity [α]25/D 71.0 to 82.0°, c = 1 in dioxane
CAS DataBase Reference 2002-29-1(CAS DataBase Reference)
FDA UNII 0DV09X6F21
EPA Substance Registry System Flumethasone-21-pivalate (2002-29-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Warning
Hazard statements  H351
Precautionary statements  P201-P202-P280-P308+P313-P405-P501
Hazard Codes  Xn
Risk Statements  40
Safety Statements  22-36
WGK Germany  3
RTECS  TU3832010
HS Code  2937220000
Toxicity mouse,LD50,oral,> 5gm/kg (5000mg/kg),Drugs in Japan Vol. 6, Pg. 705, 1982.

Flumethasone 21-pivalate price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich F0891 Flumethasone pivalate 2002-29-1 100mg $177 2023-06-20 Buy
Sigma-Aldrich F0188500 Flumethasone pivalate European Pharmacopoeia (EP) Reference Standard 2002-29-1 f0188500 $153 2024-03-01 Buy
TRC F455015 Flumethasone21-Pivalate 2002-29-1 10mg $65 2021-12-16 Buy
TRC F455015 Flumethasone21-Pivalate 2002-29-1 50mg $110 2021-12-16 Buy
AK Scientific Q560 Flumethasone pivalate 2002-29-1 100mg $238 2021-12-16 Buy
Product number Packaging Price Buy
F0891 100mg $177 Buy
F0188500 f0188500 $153 Buy
F455015 10mg $65 Buy
F455015 50mg $110 Buy
Q560 100mg $238 Buy

Flumethasone 21-pivalate Chemical Properties,Uses,Production

Chemical Properties

White or almost white, crystalline powder.

Uses

An anti-inflammatory anti-itching corticosteroid found in topical creams.

Uses

flumethasone pivalate is a moderately potent difluorinated corticosteroid ester with anti-inflammatory, antipruritic and vasoconstrictive properties. As it is a pivalate, its anti-inflammatory action is concentrated at the site of application. This local effect on diseased areas results in a prompt decrease in inflammation, exudation and itching.

Definition

ChEBI: Flumethasone pivalate is a pivalate ester, a glucocorticoid, an 11beta-hydroxy steroid, a 17alpha-hydroxy steroid, a 20-oxo steroid, a fluorinated steroid, a 3-oxo-Delta(1),Delta(4)-steroid and a tertiary alpha-hydroxy ketone. It has a role as an anti-inflammatory drug and an antipruritic drug. It is functionally related to a flumethasone.

brand name

Locorten (Novartis).

Flumethasone 21-pivalate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 94)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649 sarah@tnjone.com China 1143 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427 sales@conier.com China 49374 58
Nanjing Shizhou Biotechnology Co., Ltd
+86-15850508050 +86-15850508050 sean.lv@synzest.com China 323 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32161 58
AFINE CHEMICALS LIMITED
+86-0571-85134551 sales@afinechem.com China 15352 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com China 52849 58
Henan Alfa Chemical Co., Ltd
China 11415 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630 bess@weibangbio.com China 18151 58
PT CHEM GROUP LIMITED
+86-85511178; +86-85511178; peter68@ptchemgroup.com China 35425 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490 info@gihichemicals.com China 49978 58

View Lastest Price from Flumethasone 21-pivalate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Flumethasone pivalate pictures 2024-11-19 Flumethasone pivalate
2002-29-1
US $55.00-139.00 / mg 99.56% 10g TargetMol Chemicals Inc.
Flumethasone Pivalate pictures 2024-04-25 Flumethasone Pivalate
2002-29-1
US $0.00 / kg 1kg 99% 20tons Shaanxi TNJONE Pharmaceutical Co., Ltd

Flumethasone 21-pivalate Spectrum

21-pivalate locacorten flumethasone 21-pivalate FLUMETHASONE PIVALATE 6a,9a-difluoro-16a-methyl-prednisolone-21-pivalate 6ALPHA,9-DIFLUORO-11BETA,17,21-TRIHYDROXY-16ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-[2,2-DIMETHYLPROPIONATE] Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-, (6.alpha.,11.beta.,16.alpha.)- 6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(2,2-dimethylpropionate) 6α,9α-Difluoro-11β,17α,21-trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione 21-pivalate 6α,9α-Difluoro-16α-methylprednisolone 21-pivalate Lorinden Losalen NSC 107680 Pivalic acid, 21-ester with 6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione (8CI) Pregna-1,4-diene-3,20-dione, 21-(2,2-dimethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-methyl-, (6α,11β,16α)- Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,17,21-trihydroxy-16α-methyl-, 21-pivalate (7CI, 8CI) locorten pregna-1,4-diene-3,20-dione,6-alpha,9-difluoro-11-beta,17,21-trihydroxy-16-alp flumetasone 21-pivalate Flumethasome pivalate Flumethasone Pivalate (200 mg) FLUMETHSONEPIVALATE (6α,11β,16α)-21-(2,2-DiMethyl-1-oxopropoxy)-6,9-difluoro-11,17-dihydroxy-16-Methyl-pregna-1,4-diene-3,20-dione FluMethasone pivalate USP Flumetasone pivalate CRS Flumethasone Pivalate (1274006) Flumethasone Impurity 13(Flumethasone 21-Pivalate) 2002-29-1 C27H36F2O6 BioChemical Antibiotics Antibiotics A-F Antibiotics A to Z Steroids Intermediates & Fine Chemicals Pharmaceuticals Organics