T0070907
- CAS No.
- 313516-66-4
- Chemical Name:
- T0070907
- Synonyms
- CS-2314;T 0070907;T0070907 USP/EP/BP;T0070907 (T-0070907;2-CHLORO-5-NITRO-N-(4-PYRIDYL)BENZAMIDE;2-CHLORO-5-NITRO-N-4-PYRIDINYLBENZAMIDE;T0070907 - CAS 313516-66-4 - Calbiochem;N1-(4-PYRIDYL)-2-CHLORO-5-NITROBENZAMIDE;BenzaMide, 2-chloro-5-nitro-N-4-pyridinyl-
- CBNumber:
- CB4771443
- Molecular Formula:
- C12H8ClN3O3
- Molecular Weight:
- 277.66
- MDL Number:
- MFCD00121849
- MOL File:
- 313516-66-4.mol
- MSDS File:
- SDS
| Melting point | >184°C (dec.) |
|---|---|
| Density | 1.498 |
| storage temp. | 2-8°C |
| solubility | DMSO: >10mg/mL |
| form | White solid |
| color | white |
| Water Solubility | Soluble in DMSO at 10mg/ml. Insoluble in water. |
| Sensitive | Light Sensitive |
| FDA UNII | N2LK5944GW |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H335-H302-H319 | |||||||||
| Precautionary statements | P305+P351+P338-P261-P280a-P304+P340-P405-P501a | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 2 | |||||||||
| HS Code | 29333990 | |||||||||
| NFPA 704 |
|
T0070907 price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T8703 | T0070907 ≥98% (HPLC) | 313516-66-4 | 5mg | $174 | 2024-03-01 | Buy |
| Alfa Aesar | J64455 | 2-Chloro-5-nitro-N-(4-pyridyl)benzamide | 313516-66-4 | 50mg | $444 | 2021-12-16 | Buy |
| Alfa Aesar | J64455 | 2-Chloro-5-nitro-N-(4-pyridyl)benzamide | 313516-66-4 | 10mg | $118 | 2021-12-16 | Buy |
| Cayman Chemical | 10026 | T0070907 ≥98% | 313516-66-4 | 1mg | $14 | 2024-03-01 | Buy |
| Cayman Chemical | 10026 | T0070907 ≥98% | 313516-66-4 | 5mg | $53 | 2024-03-01 | Buy |
T0070907 Chemical Properties,Uses,Production
Description
The peroxisome proliferator-
Chemical Properties
Off-White Solid
Uses
A cell-permeable chloro-nitro-benzamido compound that acts as a potent, specific, irreversible, and high-affinity antagonist of PPAR with a Ki of 1 nM. Displays >800-fold greater selectivity for PPAR over PPARa and PPARd (Ki = 0.85 and 1.8 ,
Uses
T0070907 has been used to reduce peroxisome proliferator-activated receptor gamma (PPAR-γ) expression in lipopolysaccharide (LPS)-induced leukemia RAW264.7 cell line. It also has been used to evaluate the involvement of wogonin in alleviating EtOH (ethanol)-induced inflammation in RAW264.7 cell line.
Definition
ChEBI: 2-chloro-5-nitro-N-pyridin-4-ylbenzamide is a carbonyl compound and an organohalogen compound.
General Description
T0070907 has antimicrotubule, antitumor and radiosensitizing properties. It decreases tubulin protein levels, which is associated with cell cycle arrest, apoptosis and also reduces metastasis of colorectal carcinoma cells. T0070907 is used as a therapeutic target in breast cancer. It stimulates proteasome-dependent degradation of tubulin.
Biological Activity
Potent and selective PPAR γ antagonist (IC 50 = 1 nM). Displays > 800-fold selectivity for PPAR γ over PPAR α and PPAR δ . In vitro, blocks transcriptional activity of PPAR γ and inhibits rosiglitazone-induced adipogenesis.
Biochem/physiol Actions
T0070907 is very similar in structure and activity to the PPAR-γ antagonist GW9662. T0070907 is more potent and has higher selectivity for PPAR-γ over all other subtypes (about 800-fold) whereas GW9662 has been reported to have some PPAR-α agonist activity.
storage
Store at RT
References
[1] lee g, elwood f, mcnally j, weiszmann j, lindstrom m, amaral k, nakamura m, miao s, cao p, learned rm, chen jl, li y. t0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities. j biol chem. 2002 may 31;277(22):19649-57.
T0070907 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32820 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29815 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32063 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23225 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38463 | 58 | |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 | sales@senfeida.com | China | 23046 | 58 |
