[2H9]-N-Butyldeoxynojirimycin Hydrochloride
- CAS No.
- 1883545-57-0
- Chemical Name:
- [2H9]-N-Butyldeoxynojirimycin Hydrochloride
- Synonyms
- Miglustat-d9 HCl;N-Butyldeoxynojirimycin-d9 (hydrochloride);[2H9]-N-Butyldeoxynojirimycin Hydrochloride
- CBNumber:
- CB48012555
- Molecular Formula:
- C10H22ClNO4
- Molecular Weight:
- 255.74
- MDL Number:
- MOL File:
- 1883545-57-0.mol
[2H9]-N-Butyldeoxynojirimycin Hydrochloride price
[2H9]-N-Butyldeoxynojirimycin Hydrochloride Chemical Properties,Uses,Production
Uses
N-Butyldeoxynojirimycin Hydrochloride-d9 is labelled N-Butyldeoxynojirimycin Hydrochloride (B691000) which is an inhibitor of a-glucosidase 1 as well as being an inhibitor of HIV cytopathicity.
Biological Activity
N-Butyldeoxynojirimycin-d9 (NB-DNJ-d9) is intended for use as an internal standard for the quantification of NB-DNJ by GC- or LC-MS. NB-DNJ is an iminosugar that inhibits UDP-glucose ceramide glucosyltransferase and β-glucosidase 2 (IC50s = 32 and 81 μM, respectively, for the rat recombinant enzymes).1 It also increases the activity of wild-type acid β-glucosidase, as well as the S364R, N370S, V15M, or M123T mutants, in COS-7 cells expressing the human enzymes when used at a concentration of 10 μM.2 NB-DNJ also inhibits HIV-1 and HIV-2 infection of peripheral blood mononuclear cells (PBMCs; IC50s = 282 and 211 μM, respectively).3 Formulations containing NB-DNJ have been used in the treatment of Gaucher disease, an inborn error of metabolism characterized as a lysosomal storage disorder resulting from substantial deficiency of β-glucosidase.
References
1.Lee, J.C., Francis, S., Dutta, D., et al.Synthesis and evaluation of eight- and four-membered iminosugar analogues as inhibitors of testicular ceramide-specific glucosyltransferase, testicular β-glucosidase 2, and other glycosidasesJ. Org. Chem.77(7)3082-3098(2012) 2.Alfonso, P., Pampín, S., Estrada, J., et al.Miglustat (NB-DNJ) works as a chaperone for mutated acid β-glucosidase in cells transfected with several Gaucher disease mutationsBlood Cells Mol. Dis.35(2)268-276(2005) 3.Pollock, S., Dwek, R.A., Burton, D.R., et al.N-Butyldeoxynojirimycin is a broadly effective anti-HIV therapy significantly enhanced by targeted liposome deliveryAIDS22(15)1961-1969(2008)
[2H9]-N-Butyldeoxynojirimycin Hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
[2H9]-N-Butyldeoxynojirimycin Hydrochloride Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai isotope chemical co.,ltd | 021-021-51600108 13062666369 | sales@chinaisotope.com | China | 4274 | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8739 | 58 |
Xi'an Ruipuyuan Biotechnology Co., Ltd | 18909235869 18909235890 | customsynthesis@rpybiotech.com | China | 155 | 58 |
TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 28091 | 58 |
Supplier | Advantage |
---|---|
Shanghai isotope chemical co.,ltd | 58 |
Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
Xi'an Ruipuyuan Biotechnology Co., Ltd | 58 |
TargetMol Chemicals Inc. | 58 |