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3-chloro-4-(pyridin-2-ylmethoxy)aniline

3-chloro-4-(pyridin-2-ylmethoxy)aniline structure

CAS No.: 524955-09-7

Chemical Name:: 3-chloro-4-(pyridin-2-ylmethoxy)aniline

Synonyms: 3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline;3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE;AKOS B033273;methoxy)aniL;oro-4-(2-pyridyL;ART-CHEM-BB B033273;Neratinib Impurity 41;UKRORGSYN-BB BBV-019513;Neratinib Intermediate1;AKOS B033273(524955-09-7)

CBNumber:: CB4801557

Molecular Formula:: C12H11ClN2O

Molecular Weight:: 234.68

MDL Number:: MFCD08699389

MOL File:: 524955-09-7.mol

MSDS File:: SDS

Last updated:2025-02-12 20:55:48

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3-chloro-4-(pyridin-2-ylmethoxy)aniline Properties

Melting point	91.0 to 95.0 °C
Boiling point	402.5±35.0 °C(Predicted)
Density	1.292±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	powder to crystal
pka	3.88±0.10(Predicted)
color	White to Light yellow to Light orange
FDA UNII	67KD7Z8H49

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P280-P302+P352-P305+P351+P338

HS Code

2933399990

NFPA 704

	0
2		0

3-chloro-4-(pyridin-2-ylmethoxy)aniline price More Price(31)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C3150	3-Chloro-4-(2-pyridylmethoxy)aniline >98.0%(GC)(T)	524955-09-7	1g	$152	2024-03-01	Buy
TCI Chemical	C3150	3-Chloro-4-(2-pyridylmethoxy)aniline >98.0%(GC)(T)	524955-09-7	5g	$456	2024-03-01	Buy
TRC	C429263	3-Chloro-4-(2-pyridylmethoxy)aniline	524955-09-7	5g	$70	2021-12-16	Buy
TRC	C429263	3-Chloro-4-(2-pyridylmethoxy)aniline	524955-09-7	10g	$110	2021-12-16	Buy
TRC	C429263	3-Chloro-4-(2-pyridylmethoxy)aniline	524955-09-7	1g	$45	2021-12-16	Buy

Product number	Packaging	Price	Buy
C3150	1g	$152	Buy
C3150	5g	$456	Buy
C429263	5g	$70	Buy
C429263	10g	$110	Buy
C429263	1g	$45	Buy

3-chloro-4-(pyridin-2-ylmethoxy)aniline Chemical Properties,Uses,Production

Physical Form

Solid

Uses

3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino)quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents.

Synthesis

3-chloro-4-(pyridin-2-ylmethoxy)aniline is synthesised using 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
The 2-((2-chloro-4-nitrophenoxy)methyl)pyridine (3.9 g, 15 mmol), zinc powder (5.8 g, 88 mmol) and ammonium chloride (2.4 g, 44 mmol) were added into a mixed solution of ethanol (60 mL) and H2O (10 mL). The mixture was stirred at 60° C. overnight. Then the reaction mixture was poured into 200 mL of H2O, extracted with ethyl acetate. The organic phase was separated, washed with saturated brine and dried. The solvent was removed in vacuo, and the compound shown in the title (3.4 g, 98percent) was obtained. 1H NMR (CDCl3): δ 8.57 (1H, d, J=4.8 Hz), 7.75-7.70 (1H, m), 7.65-7.63 (1H, m), 7.23-7.20 (1H, m), 6.81 (1H, d, J=9.2 Hz), 6.77 (1H, d, J=2.8 Hz), 5.18 (2H, s), 3.48 (2H, br).
3-chloro-4-(pyridin-2-ylmethoxy)aniline synthesis

3-chloro-4-(pyridin-2-ylmethoxy)aniline Preparation Products And Raw materials

Raw materials

Preparation Products

3-chloro-4-(pyridin-2-ylmethoxy)aniline Suppliers

Global( 260)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	export01@shyrchem.com	CHINA	1319	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29792	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21632	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	FandaChem@Gmail.com	China	8441	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29871	58
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	stella@zetchem.com	China	2136	58
Hangzhou Cyanochem Co., Ltd.	+86 17788583750	sales@cyanochem.com	CHINA	281	58

Supplier	Advantage
Shanghai Yingrui Biopharma Co.,Ltd	58
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
Shanghai Yingrui Biopharma Co., Ltd.	60
Anqing Chico Pharmaceutical Co., Ltd.	58
career henan chemical co	58
Zhejiang ZETian Fine Chemicals Co. LTD	58
Hangzhou Cyanochem Co., Ltd.	58

View Lastest Price from 3-chloro-4-(pyridin-2-ylmethoxy)aniline manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-02-13	3-chloro-4-(pyridin-3-ylMethoxy)aniline 524955-09-7	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2025-02-12	3-chloro-4-(pyridin-3-ylMethoxy)aniline 524955-09-7	US $0.00-0.00 / Kg/Bag	100g	98%min	100kg	WUHAN FORTUNA CHEMICAL CO., LTD
2024-11-26	3-chloro-4-(pyridin-2-ylmethoxy)aniline 524955-09-7	US $0.00-0.00 / kg	1kg	98%	1 ton	Nanjing Fred Technology Co., Ltd

3-chloro-4-(pyridin-3-ylMethoxy)aniline
524955-09-7
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

3-chloro-4-(pyridin-3-ylMethoxy)aniline
524955-09-7
US $0.00-0.00 / Kg/Bag
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

3-chloro-4-(pyridin-2-ylmethoxy)aniline
524955-09-7
US $0.00-0.00 / kg
98%
Nanjing Fred Technology Co., Ltd

3-chloro-4-(pyridin-2-ylmethoxy)aniline Spectrum

AKOS B033273(524955-09-7)¹HNMR

524955-09-7(3-chloro-4-(pyridin-2-ylmethoxy)aniline)Related Search:

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AKOS B033273 3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-PHENYLAMINE ART-CHEM-BB B033273 UKRORGSYN-BB BBV-019513 3-chloro-4-(2-pyridinylMethoxy)- BenzenaMine 3-Chloro-4-[(pyridin-2-yl)Methoxy]benzenaMine [3-Chloro-4-(pyridin-2-ylMethoxy)phenyl]aMine BenzenaMine, 3-chloro-4-(2-pyridinylMethoxy)- Neratinib Intermediate1 3-Chloro-4-(pyridin-2-ylmethoxy) 3-Chloro-4-(2-pyridylmethoxy)aniline 3-Chloro-4-(pyridine-2-ylmethoxy)aniline AKOS B033273(524955-09-7) 4-((pyridin-2-yl)methoxy)-3-chlorobenzenamine methoxy)aniL oro-4-(2-pyridyL AKOS B033273 ISO 9001：2015 REACH Neratinib Impurity 41 524955-09-7 AKOS B033273 3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE 3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline 3-Chloro-4-(pyridin-2-ylmethoxy)aniline (Neratinib Impurity) 3-chloro-4-(pyridin-2-ylmethoxy)aniline 3-chloro-4-(2-pyridinylmethoxy) benzeneamine 524955-09-7 524955-09-7