3-chloro-4-(pyridin-2-ylmethoxy)aniline
- CAS No.
- 524955-09-7
- Chemical Name:
- 3-chloro-4-(pyridin-2-ylmethoxy)aniline
- Synonyms
- 3-Chloro-4-[(pyridin-2-yl)Methyloxy]aniline;3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)-BENZENAMINE;AKOS B033273;methoxy)aniL;oro-4-(2-pyridyL;ART-CHEM-BB B033273;Neratinib Impurity 41;UKRORGSYN-BB BBV-019513;Neratinib Intermediate1;AKOS B033273(524955-09-7)
- CBNumber:
- CB4801557
- Molecular Formula:
- C12H11ClN2O
- Molecular Weight:
- 234.68
- MDL Number:
- MFCD08699389
- MOL File:
- 524955-09-7.mol
- MSDS File:
- SDS
Melting point | 91.0 to 95.0 °C |
---|---|
Boiling point | 402.5±35.0 °C(Predicted) |
Density | 1.292±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
form | powder to crystal |
pka | 3.88±0.10(Predicted) |
color | White to Light yellow to Light orange |
FDA UNII | 67KD7Z8H49 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P280-P302+P352-P305+P351+P338 | |||||||||
HS Code | 2933399990 | |||||||||
NFPA 704 |
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3-chloro-4-(pyridin-2-ylmethoxy)aniline price More Price(31)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | C3150 | 3-Chloro-4-(2-pyridylmethoxy)aniline >98.0%(GC)(T) | 524955-09-7 | 1g | $152 | 2024-03-01 | Buy |
TCI Chemical | C3150 | 3-Chloro-4-(2-pyridylmethoxy)aniline >98.0%(GC)(T) | 524955-09-7 | 5g | $456 | 2024-03-01 | Buy |
TRC | C429263 | 3-Chloro-4-(2-pyridylmethoxy)aniline | 524955-09-7 | 5g | $70 | 2021-12-16 | Buy |
TRC | C429263 | 3-Chloro-4-(2-pyridylmethoxy)aniline | 524955-09-7 | 10g | $110 | 2021-12-16 | Buy |
TRC | C429263 | 3-Chloro-4-(2-pyridylmethoxy)aniline | 524955-09-7 | 1g | $45 | 2021-12-16 | Buy |
3-chloro-4-(pyridin-2-ylmethoxy)aniline Chemical Properties,Uses,Production
Physical Form
Solid
Uses
3-Chloro-4-(2-pyridylmethoxy)aniline was used for preparation of disubstituted (arylamino)quinolinecarbonitriles as orally active irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity and antitumor agents.
Synthesis
3-chloro-4-(pyridin-2-ylmethoxy)aniline is synthesised using 2-((2-Chloro-4-nitrophenoxy)methyl)pyridine as a raw material by chemical reaction. The specific synthesis steps are as follows:
The 2-((2-chloro-4-nitrophenoxy)methyl)pyridine (3.9 g, 15 mmol), zinc powder (5.8 g, 88 mmol) and ammonium chloride (2.4 g, 44 mmol) were added into a mixed solution of ethanol (60 mL) and H2O (10 mL).
The mixture was stirred at 60° C. overnight.
Then the reaction mixture was poured into 200 mL of H2O, extracted with ethyl acetate.
The organic phase was separated, washed with saturated brine and dried.
The solvent was removed in vacuo, and the compound shown in the title (3.4 g, 98percent) was obtained.
1H NMR (CDCl3): δ 8.57 (1H, d, J=4.8 Hz), 7.75-7.70 (1H, m), 7.65-7.63 (1H, m), 7.23-7.20 (1H, m), 6.81 (1H, d, J=9.2 Hz), 6.77 (1H, d, J=2.8 Hz), 5.18 (2H, s), 3.48 (2H, br).
3-chloro-4-(pyridin-2-ylmethoxy)aniline Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | export01@shyrchem.com | CHINA | 1320 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21667 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9337 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29889 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | +8618957127338 | stella@zetchem.com | China | 2136 | 58 |
Hangzhou Cyanochem Co., Ltd. | +86 17788583750 | sales@cyanochem.com | CHINA | 283 | 58 |
View Lastest Price from 3-chloro-4-(pyridin-2-ylmethoxy)aniline manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-09-04 | 3-chloro-4-(pyridin-3-ylMethoxy)aniline
524955-09-7
|
US $0.00-0.00 / Kg/Bag | 100g | 98%min | 100kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2024-05-09 | 3-chloro-4-(pyridin-2-ylmethoxy)aniline
524955-09-7
|
US $0.00-0.00 / kg | 1kg | 98% | 1 ton | Nanjing Fred Technology Co., Ltd | |
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2023-04-12 | AKOS B033273
524955-09-7
|
US $14.00 / Kg/Bag | 1Kg/Bag | 99.6% | Weekly supply of 1000 KG | Wuhan Dujiang Industrial Co., Ltd. |
-
- 3-chloro-4-(pyridin-3-ylMethoxy)aniline
524955-09-7
- US $0.00-0.00 / Kg/Bag
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- 3-chloro-4-(pyridin-2-ylmethoxy)aniline
524955-09-7
- US $0.00-0.00 / kg
- 98%
- Nanjing Fred Technology Co., Ltd
-
- AKOS B033273
524955-09-7
- US $14.00 / Kg/Bag
- 99.6%
- Wuhan Dujiang Industrial Co., Ltd.
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