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PROTAC PARP1 degrader

PROTAC PARP1 degrader Structure
PROTAC PARP1 degrader structure
CAS No.
2369022-68-2
Chemical Name:
PROTAC PARP1 degrader
Synonyms
PROTAC PARP1 degrader;2-(4-(1-(1-(4-((4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)-2-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-17-yl)-1H-1,2,3-triazol-4-yl)phenyl)-2H-indazole-7-carboxamide;2-(4-{1-[14-(2-{4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazole-1-carbonyl]-2-oxopiperazin-1-yl}acetamido)-3,6,9,12-tetraoxatetradecan-1-yl]-1H-1,2,3-triazol-4-yl}phenyl)-2H-indazole-7-carboxamide;2H-Indazole-7-carboxamide, 2-[4-[1-[17-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-1-piperazinyl]-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]phenyl]-
CBNumber:
CB48054607
Molecular Formula:
C58H63Cl2N11O10
Molecular Weight:
1145.09
MDL Number:
MFCD32705102
MOL File:
2369022-68-2.mol
Last updated:2025-04-17 18:22:24
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PROTAC PARP1 degrader Properties

Density 1.39±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
form Solid
pka 14.32±0.46(Predicted)
color White to off-white

PROTAC PARP1 degrader Chemical Properties,Uses,Production

Uses

PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. PROTAC PARP1 degrader induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader consists of E3 ubiquitinase ligand MDM2 ligand (HY-128836), blue part; target protein ligand PAPR1 ligand (HY-171543), red part; PROTAC linker N3-PEG4-C2-NH2 (HY-128834), black part[1][2].

Biological Activity

PROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.

IC 50

PARP1; MDM2

References

[1]. Zhao Q, et al. Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule. Chem Commun (Camb). 2019 Jan 2;55(3):369-372.

PROTAC PARP1 degrader Preparation Products And Raw materials

Raw materials

Preparation Products

PROTAC PARP1 degrader Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32202 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7787 56
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1592 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18478 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24683 58
Henan Alpha Chemical Co., Ltd. 0371-55013243 15324716602 2853979810@qq.com China 10003 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 13417589054 trendseenbio@gmail.com China 9070 58
Suzhou Zhongke New Drug Basket Biomedical Technology Co., Ltd. 13616278204 shenlei@supharm.cn China 87 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 sales@chemhifuture.com China 5237 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 025-58851090 17714375163 2881759498@qq.com China 13012 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Jilin Province Woda Biotechnology Co., Ltd. 58
Changzhou Bojia Biomedical Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Henan Alpha Chemical Co., Ltd. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Suzhou Zhongke New Drug Basket Biomedical Technology Co., Ltd. 58
Nantong QuanYi Biotechnology Co., Ltd 58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd 58

2369022-68-2(PROTAC PARP1 degrader)Related Search:

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SGK3 degrader-1 Sirt2-PROTAC-1 PROTAC MDM2 Degrader-3 PROTAC Mcl1 degrader-1

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PROTAC PARP1 degrader 2H-Indazole-7-carboxamide, 2-[4-[1-[17-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-1-piperazinyl]-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]phenyl]- 2-(4-(1-(1-(4-((4R,5S)-4,5-Bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)-2-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-17-yl)-1H-1,2,3-triazol-4-yl)phenyl)-2H-indazole-7-carboxamide 2-(4-{1-[14-(2-{4-[(4R,5S)-4,5-bis(4-chlorophenyl)-2-[4-methoxy-2-(propan-2-yloxy)phenyl]-4,5-dihydro-1H-imidazole-1-carbonyl]-2-oxopiperazin-1-yl}acetamido)-3,6,9,12-tetraoxatetradecan-1-yl]-1H-1,2,3-triazol-4-yl}phenyl)-2H-indazole-7-carboxamide 2369022-68-2