NEP
- CAS No.
- 2414276-32-5
- Chemical Name:
- NEP
- Synonyms
- NEP
- CBNumber:
- CB48648318
- Molecular Formula:
- C29H31AsN4O5S2
- Molecular Weight:
- 654.63
- MDL Number:
- MOL File:
- 2414276-32-5.mol
NEP Chemical Properties,Uses,Production
Biological Activity
NEP (VDP-green (NEP)) is an intramolecular charge transfer (ICT)-based sensing fluorescent probe for sensing orthodithiol-containing proteins (VDPs). NEP exhibits high selectivity for VDPs in living cells and animals, and displays a strong green fluorescence signal (λex/λem=430/535 nm). NEP has potential for Parkinson's research.
in vitro
NEP (1-30 μM; 6 hours) has no or little cytotoxicity in HepG2 and PC12 cells.
NEP (10 μM; 4 hours) causes the fluorescence intensity to decrease gradually in PC12 cells pretreated with 6-OHDA (0, 50, 100, and 200 μM; for 30 min).
NEP contains a dithiarsolane moiety (five-membered As-S ring) as the receptor of VDPs. In the presence of VDPs, NEP displays a strong green fluorescence signal produced by the cyclic dithiarsolane cleavage and subsequent intramolecular cyclization to liberate the fluorophore. NEP maintains a reliable fluorescence response within the range of pH 7-10.
in vivo
NEP (10 μM; for 4 h) causes the obvious green signal in zebrafishes (4 day old).
NEP Preparation Products And Raw materials
Raw materials
Preparation Products
NEP Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| MedChemExpress | -- | sales@medchemexpress.com | United States | 6398 | 58 |
| Supplier | Advantage |
|---|---|
| MedChemExpress | 58 |