piritramide
- CAS No.
- 302-41-0
- Chemical Name:
- piritramide
- Synonyms
- A 65;R 3365;Pirdolan;Piridolan;Dipidolor;Pirtramide;piritramide;Pirinitramide;DipiritraMide;Piritramide (1 mg/mL in Methanol)
- CBNumber:
- CB4893624
- Molecular Formula:
- C27H34N4O
- Molecular Weight:
- 430.59
- MDL Number:
- MOL File:
- 302-41-0.mol
| Melting point | 149-150° |
|---|---|
| Boiling point | 544.82°C (rough estimate) |
| Density | 1.0967 (rough estimate) |
| refractive index | 1.5900 (estimate) |
| storage temp. | Controlled Substance, -20°C Freezer |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 16.19±0.20(Predicted) |
| color | White to Pale Beige |
| FDA UNII | 4RP92LYZ2F |
| NCI Drug Dictionary | piritramide |
| ATC code | N02AC03 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H315-H319-H335-H302 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501 |
piritramide Chemical Properties,Uses,Production
Chemical Properties
Off-White Low Melting Solid
Originator
Dipidolor ,Janssen W. ,Germany,1969
Uses
Piritramide is a synthetic opioid commonly used in Germany and Austria for the analgesia of pediatric patients.
Definition
ChEBI: Piritramide is a nitrile.
Manufacturing Process
A mixture of 84 parts of 3,3-diphenyl-3-cyanopropyl bromide, 41 parts of 4piperidino-4-piperidinecarboxamide, 64 parts of sodium carbonate, a small amount of potassium iodide and 1,200 parts of anhydrous toluene was stirred, and heated under reflux for 48 hours. At the end of this time the reaction mixture was allowed to cool to room temperature, and 500 parts of water were added. The resultant precipitate was removed by filtration, and triturated with diisopropyl ether. The crystalline material thus obtained was removed by filtration, and recrystallized from 320 parts of acetone, to give 1-(3,3diphenyl-3-cyanopropyl)-4-piperidino-4-piperidinecarboxamide, melting at about 149°C to 150°C.
Therapeutic Function
Analgesic
piritramide Preparation Products And Raw materials
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