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Thalidomide-O-amido-C8-NH2 hydrochloride

Thalidomide-O-amido-C8-NH2 hydrochloride Structure
Thalidomide-O-amido-C8-NH2 hydrochloride structure
CAS No.
2415263-07-7
Chemical Name:
Thalidomide-O-amido-C8-NH2 hydrochloride
Synonyms
Thalidomide-O-amido-C8-NH2 hydrochloride;N-(8-aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide hydrochloride
CBNumber:
CB49023929
Molecular Formula:
C23H31ClN4O6
Molecular Weight:
494.97
MDL Number:
MOL File:
2415263-07-7.mol
Last updated:2024-04-01 13:48:23
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Thalidomide-O-amido-C8-NH2 hydrochloride Chemical Properties,Uses,Production

Biological Activity

Thalidomide-O-amido-C8-NH2 hydrochloride, a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker, can be used in the synthesis of PROTACs[1]. Thalidomide-O-amido-C8-NH2 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is bound lo at least one targeting ligand. Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein(s)[1].

storage

Desiccate at RT

References

[1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.

Thalidomide-O-amido-C8-NH2 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Thalidomide-O-amido-C8-NH2 hydrochloride Suppliers

Global( 10)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanxi Tihondan Pharmaceutical Technology Co., Ltd 		+8618235132063 sales@tihondan.com China 3741 58
Xian confluore Biological Technology Co., Ltd. 		+86-15680926068 +86-15680926068 1924344760@confluore.cn China 2996 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4825 58
SuZhou Medinoah Co.,LTD. 0512-69561983 13914027025 zhang_q@medinoah.com China 3606 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1458 58
Changzhou Bojia Biomedical Technology Co., Ltd. 2122619822 czbjpharma@126.com China 18478 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 13417589054 trendseenbio@gmail.com China 9470 58
Abosyn 0512-69561983 13914027025 he_qf@medinoah.com China 3001 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. +86-18521732826 market@aladdin-e.com China 48461 58
Supplier Advantage
Shanxi Tihondan Pharmaceutical Technology Co., Ltd 		58
Xian confluore Biological Technology Co., Ltd. 		58
Aladdin Scientific 		58
Xi'an Confluore Biological Technology Co., Ltd. 58
SuZhou Medinoah Co.,LTD. 58
Jilin Province Woda Biotechnology Co., Ltd. 58
Changzhou Bojia Biomedical Technology Co., Ltd. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Abosyn 58
Shanghai Aladdin Biochemical Technology Co.,Ltd. 58

View Lastest Price from Thalidomide-O-amido-C8-NH2 hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Thalidomide-O-amido-C8-NH2 hydrochloride pictures 2024-04-02 Thalidomide-O-amido-C8-NH2 hydrochloride
2415263-07-7
 US $0.00 / mg 100mg >98.00% 100mg Xian confluore Biological Technology Co., Ltd.

2415263-07-7(Thalidomide-O-amido-C8-NH2 hydrochloride)Related Search:

Thalidomide-O-amido-PEG4-azide Thalidomide-O-amido-PEG4-C2-NH2 hydrochloride Thalidomide-linker 14 N-(4-azidobutyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide E3 Ligase Ligand-Linker Conjugates 24 (TFA)
1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- Cereblon Ligand 1 E3 Ligase Ligand-Linker Conjugates 21 E3 Ligase Ligand-Linker Conjugates 19 Thalidomide-O-PEG4-Propargyl
Thalidomide-linker 10 Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride Thalidomide-O-PEG4-Boc
tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate Thalidomide-linker 13 Thalidomide-linker 15

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Thalidomide-O-amido-C8-NH2 hydrochloride N-(8-aminooctyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetamide hydrochloride 2415263-07-7