ELOVL6-IN-1
- CAS No.
- 1185736-98-4
- Chemical Name:
- ELOVL6-IN-1
- Synonyms
- ELOVL6-IN-1;ELOVL6IN1,noncompetitive,orally,palmitoyl-CoA,potent,malonyl-CoA,ELOVL-6-IN-1,Inhibitor,selective,ELOVL6 IN 1,inhibit;1H-Indole-2,4-dione, 3-(2,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)-3,5,6,7-tetrahydro-5,5-dimethyl-1-phenyl-3-(trifluoromethyl)-
- CBNumber:
- CB49380433
- Molecular Formula:
- C27H24F3N3O3
- Molecular Weight:
- 495.49
- MDL Number:
- MOL File:
- 1185736-98-4.mol
ELOVL6-IN-1 Chemical Properties,Uses,Production
Biological Activity
ELOVL6-IN-1 is a potent, orally active and selective ELOVL6 inhibitor. ELOVL6-IN-1 dose-dependently inhibits mouse ELOVL6 activities, with an IC50 value of 0.350 μM. ELOVL6-IN-1 inhibits ELOVL6 in a noncompetitive manner for malonyl-CoA (Ki=994 nM) and palmitoyl-CoA[1]. ELOVL6-IN-1 has sufficiently lipophilic having the potential to penetrate the intracellular space in a passive diffusion manner[1]. ELOVL6-IN-1 (10 mg/kg; p.o.; 0~2 hours) displays appreciable plasma and liver exposure[1].ELOVL6-IN-1 (10 and 30 mg/kg; p.o.; 0~2 hours) reduces the elongation index of the liver lipids[1].ELOVL6-IN-1 (100 mg/kg; p.o.; 2 days) reduces the elongation index of the total fatty acids of the liver[1].
References
[1]. Shimamura K, et al. 5,5-Dimethyl-3-(5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-1-phenyl-3-(trifluoromethyl)-3,5,6,7-tetrahydro-1H-indole-2,4-dione, a potent inhibitor for mammalian elongase of long-chain fatty acids family 6: examination of its potential utility as a pharmacological tool. J Pharmacol Exp Ther. 2009;330(1):249-256.
ELOVL6-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
ELOVL6-IN-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Shanghai Beckham Medical Technology Co., Ltd | 021-13816613772 13816613772 | huahero21@sina.com | China | 377 | 55 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8010 | 62 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24017 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Shanghai Beckham Medical Technology Co., Ltd | 55 |
| ShangHai Biochempartner Co.,Ltd | 62 |
| TargetMol Chemicals Inc. | 58 |