ChemicalBook >> CAS DataBase List >>INDEX NAME NOT YET ASSIGNED
INDEX NAME NOT YET ASSIGNED
- CAS No.
- 2738688-57-6
- Chemical Name:
- INDEX NAME NOT YET ASSIGNED
- Synonyms
- CBP/p300-IN-12
- CBNumber:
- CB511614839
- Molecular Formula:
- C33H29F4N5O6
- Molecular Weight:
- 667.61
- MDL Number:
- MOL File:
- Mol file
Last updated:2023-07-14 17:28:39
INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production
Biological Activity
CBP/p300-IN-12 is a potent and selective covalent histone acetyltransferases p300 (IC50 of 166 nM) and CBP inhibitor. CBP/p300-IN-12 decreases the levels of H3K27Ac of PC-3 cells (EC50 of 37 nM). CBP/p300-IN-12 forms a covalent adduct with C1450[1]. CBP/p300-IN-12 (Compound 2) shows antiproliferative effect against androgen receptor (AR)-positive LnCaP-FGC cells (EC50 of 87 nM), while displaying significantly less activity in the AR-negative cell line DU-145 (EC50 of 1.37 μM).
References
[1]. Anthony Mastracchio, et al. Discovery of a Potent and Selective Covalent p300/CBP Inhibitor. ACS Med Chem Lett. 2021 Apr 5;12(5):726-731.
INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials
Raw materials
Preparation Products
INDEX NAME NOT YET ASSIGNED Suppliers
Global( 1)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Supplier | Advantage |
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Aladdin Scientific | 58 |
CBP/p300-IN-12
2738688-57-6
C33H29F4N5O6