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INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED Structure
INDEX NAME NOT YET ASSIGNED structure
CAS No.
2641601-67-2
Chemical Name:
INDEX NAME NOT YET ASSIGNED
Synonyms
PROTAC EZH2 Degrader-1
CBNumber:
CB511784859
Molecular Formula:
C54H67N7O8
Molecular Weight:
942.17
MDL Number:
MOL File:
2641601-67-2.mol
Last updated:2024-07-02 08:55:09
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INDEX NAME NOT YET ASSIGNED Properties

Boiling point 1066.8±65.0 °C(Predicted)
Density 1.234±0.06 g/cm3(Predicted)
storage temp. -20°C, away from moisture
solubility DMSO : 160 mg/mL (169.82 mM; Need ultrasonic)
pka 10.70±0.40(Predicted)
form Solid
color Off-white to light yellow

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Biological Activity

PROTAC EZH2 Degrader-1 (Compound 150d), a potent PROTAC EZH2 Degrader, exerts inhibitory effect on EZH2 methyltransferase activity with the IC50 of 2.7 nM. EZH2 plays an important role in many tumorigenesis and development processes[1].

References

[1]. Juan Xia, et al. Targeting Enhancer of Zeste Homolog 2 for the Treatment of Hematological Malignancies and Solid Tumors: Candidate Structure-Activity Relationships Insights and Evolution Prospects. J Med Chem. 2022 May 26;65(10):7016-7043.

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 1)Suppliers
Supplier Tel Email Country ProdList Advantage
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1381 58
Supplier Advantage
Jilin Province Woda Biotechnology Co., Ltd. 58
PROTAC EZH2 Degrader-1 2641601-67-2 C54H67N7O8