ChemicalBook >> CAS DataBase List >>2H-Indol-2-one, 3-(4,4-difluoro-1-piperidinyl)-1,3-dihydro-3-(4-hydroxyphenyl)-7-(trifluoromethyl)-, (3R)-

2H-Indol-2-one, 3-(4,4-difluoro-1-piperidinyl)-1,3-dihydro-3-(4-hydroxyphenyl)-7-(trifluoromethyl)-, (3R)-

2H-Indol-2-one, 3-(4,4-difluoro-1-piperidinyl)-1,3-dihydro-3-(4-hydroxyphenyl)-7-(trifluoromethyl)-, (3R)- structure

CAS No.: 2768139-76-8

Chemical Name:: 2H-Indol-2-one, 3-(4,4-difluoro-1-piperidinyl)-1,3-dihydro-3-(4-hydroxyphenyl)-7-(trifluoromethyl)-, (3R)-

Synonyms: (3R)-3-(4,4-difluoro-1-piperidyl)-3-(4-hydroxyphenyl)-7-(trifluoromethyl)indolin-2-one;(R)-3-(4,4-Difluoropiperidin-1-yl)-3-(4-hydroxyphenyl)-7-(trifluoromethyl)indolin-2-one;2H-Indol-2-one, 3-(4,4-difluoro-1-piperidinyl)-1,3-dihydro-3-(4-hydroxyphenyl)-7-(trifluoromethyl)-, (3R)-

CBNumber:: CB512231671

Molecular Formula:: C20H17F5N2O2

Molecular Weight:: 412.35

MDL Number:

MOL File:: 2768139-76-8.mol

Last updated:2024-07-02 08:55:09

Request For Quotation

2H-Indol-2-one, 3-(4,4-difluoro-1-piperidinyl)-1,3-dihydro-3-(4-hydroxyphenyl)-7-(trifluoromethyl)-, (3R)- Properties

Boiling point	485.1±45.0 °C(Predicted)
Density	1.49±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	9?+-.0.30(Predicted)
form	Solid
color	White to pink

2H-Indol-2-one, 3-(4,4-difluoro-1-piperidinyl)-1,3-dihydro-3-(4-hydroxyphenyl)-7-(trifluoromethyl)-, (3R)- Chemical Properties,Uses,Production

Biological Activity

ErSO-DFP is an anticipatory unfolded protein response (a-UPR) activator. ErSO-DFP has enhanced selectivity for estrogen receptor alpha-positive (ERα+) cancer cells with a wider selectivity window than ErSO.ErSO-DFP displays antitumor activity and leads to profound regression of MCF-7 tumors in mice model[1].

References

[1]. Matthew W Boudreau, et al. Activators of the Anticipatory Unfolded Protein Response with Enhanced Selectivity for Estrogen Receptor Positive Breast Cancer. J Med Chem. 2022 Mar 10;65(5):3894-3912.

2H-Indol-2-one, 3-(4,4-difluoro-1-piperidinyl)-1,3-dihydro-3-(4-hydroxyphenyl)-7-(trifluoromethyl)-, (3R)- Preparation Products And Raw materials

Raw materials

Preparation Products

2H-Indol-2-one, 3-(4,4-difluoro-1-piperidinyl)-1,3-dihydro-3-(4-hydroxyphenyl)-7-(trifluoromethyl)-, (3R)- Suppliers

Global( 3)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou ARTK Medchem Co., Ltd.	+86-512-68323658 +86-18168183658	sales1@artkmedchem.com	China	39010	58
Bide Pharmatech Ltd.	400-1647117 13681763483	product02@bidepharm.com	China	62163	58
PharmaBlock Sciences (Nanjing), Inc.	4000255188 4000255188	sales@pharmablock.com	China	7268	58

Supplier	Advantage
Suzhou ARTK Medchem Co., Ltd.	58
Bide Pharmatech Ltd.	58
PharmaBlock Sciences (Nanjing), Inc.	58

2H-Indol-2-one, 3-(4,4-difluoro-1-piperidinyl)-1,3-dihydro-3-(4-hydroxyphenyl)-7-(trifluoromethyl)-, (3R)- (3R)-3-(4,4-difluoro-1-piperidyl)-3-(4-hydroxyphenyl)-7-(trifluoromethyl)indolin-2-one (R)-3-(4,4-Difluoropiperidin-1-yl)-3-(4-hydroxyphenyl)-7-(trifluoromethyl)indolin-2-one 2768139-76-8