Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>DMP 777

DMP 777

DMP 777 Structure
DMP 777 structure
CAS No.
157341-41-8
Chemical Name:
DMP 777
Synonyms
DMP 777;L 694458;L-694458; DMP-777; DMP777;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl);(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phe;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-Methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxaMide;(2S)-N-[(1R)-1-(1,3-Benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide;1-AzetidinecarboxaMide,N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-,(2S)-;(S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide (3.5% w/w solution)
CBNumber:
CB51333719
Molecular Formula:
C31H40N4O6
Molecular Weight:
564.67
MDL Number:
MFCD00871548
MOL File:
157341-41-8.mol
Last updated:2024-10-23 13:36:13
Request For Quotation

DMP 777 Properties

Density 1.227
storage temp. Store at -20°C
solubility DMSO : 38.33 mg/mL (67.88 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form Powder
pka pKa 7.04(H2O tunde?ned Iunde?ned) (Uncertain)
FDA UNII 3Q0469283P

DMP 777 price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0355 DMP777 99.13% 157341-41-8 10mg $300 2021-12-16 Buy
Biosynth Carbosynth FB167347 (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide 157341-41-8 2mg $300 2021-12-16 Buy
American Custom Chemicals Corporation KIN0001205 L-694458 95.00% 157341-41-8 5MG $496.38 2021-12-16 Buy
ChemScene CS-0355 DMP777 99.13% 157341-41-8 25mg $510 2021-12-16 Buy
ChemScene CS-0355 DMP777 99.13% 157341-41-8 5mg $200 2021-12-16 Buy
Product number Packaging Price Buy
CS-0355 10mg $300 Buy
FB167347 2mg $300 Buy
KIN0001205 5MG $496.38 Buy
CS-0355 25mg $510 Buy
CS-0355 5mg $200 Buy

DMP 777 Chemical Properties,Uses,Production

Biological Activity

DMP 777 is a potent, selective, orally available inhibitor of human leukocyte elastase (HLE).

in vivo

DMP-777-treated rats show a marked decrease in H/K-ATPase staining parietal cells. DMP-777-induced loss of parietal cells is significantly ameliorated with coadministration of omeprazole. DMP-777-treated animals demonstrates marked foveolar hyperplasia in the fundus with prominent expansion of diastase-resistant, PAS-positive surface mucous cells. When DMP-777 is coadministered with omprazole, there is a significant decrease in BrdUpositive S-phase cells compared with rats that receive DMP-777 alone. After oral dosing of monkeys at 40 mg/kg with DMP-777 the only stereoisomer detected in the post-dose plasma samples is the starting material DMP-777, and no inversion of the configuration at positions 'a' and 'b' of DMP- 777 has occurred in vivo. Mist1-/- mice treated with DMP-777 show fewer chief cell to SPEM transitions. Mist1-/- mice treated with L635 demonstrates significantly fewer proliferative SPEM cells compared to control mice.

target

Human leukocyte elastase (HLE)

DMP 777 Preparation Products And Raw materials

Raw materials

Preparation Products

DMP 777 Suppliers

Global( 47)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49374 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226 sales@hzclap.com CHINA 6312 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
TargetMol Chemicals Inc. 		+8613564774135 zijue.cai@tsbiochem.com United States 19885 58
Chembest Research Laboratories Limited +86-21-20908456 sales@BioChemBest.com China 6005 61
Shanghai Holy Biohemdeviser Co., Ltd 021-61551100 China 444 57
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7552 61
MedChemexpress LLC 021-58955995 sales@medchemexpress.cn United States 4861 58
SPIRO PHARMA eric_feng1954@126.com China 9248 55
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
TargetMol Chemicals Inc. 		58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		58
Aladdin Scientific 		58
TargetMol Chemicals Inc. 		58
Chembest Research Laboratories Limited 61
Shanghai Holy Biohemdeviser Co., Ltd 57
Haoyuan Chemexpress Co., Ltd. 61
MedChemexpress LLC 58
SPIRO PHARMA 55

View Lastest Price from DMP 777 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
DMP 777 pictures 2024-10-24 DMP 777
157341-41-8
 US $95.00-163.00 / mg 10g TargetMol Chemicals Inc.
  • DMP 777 pictures
  • DMP 777
    157341-41-8
  • US $95.00-163.00 / mg
  • TargetMol Chemicals Inc.

157341-41-8(DMP 777)Related Search:

N,N'-Ethylenebis(stearamide) Sulfanilamide
DMP 777 (2S)-N-[(1R)-1-(1,3-Benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-1-azetidinecarboxamide (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl) 1-AzetidinecarboxaMide,N-[(1R)-1-(1,3-benzodioxol-5-yl)butyl]-3,3-diethyl-2-[4-[(4-Methyl-1-piperazinyl)carbonyl]phenoxy]-4-oxo-,(2S)- (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4-Methylpiperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxaMide (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phe L 694458 (S)-N-((R)-1-(Benzo[d][1,3]dioxol-5-yl)butyl)-3,3-diethyl-2-(4-(4methyl-piperazine-1-carbonyl)phenoxy)-4-oxoazetidine-1-carboxamide (3.5% w/w solution) L-694458; DMP-777; DMP777 157341-41-8 C31H40N4O6