Nefazodone
- CAS No.
- 83366-66-9
- Chemical Name:
- Nefazodone
- Synonyms
- SERZONE;Dutonin;Nefadar;BMY-13754;NEFAZODONE;MJ-13754-1;MJ-13754-I;Nefazodone base;l)-5-ethyl-4-(2-phenoxyethyl)-;Nefazodone (base and/or unspecified salts)
- CBNumber:
- CB5144862
- Molecular Formula:
- C25H32ClN5O2
- Molecular Weight:
- 470.01
- MDL Number:
- MFCD00865396
- MOL File:
- 83366-66-9.mol
- MSDS File:
- SDS
Melting point | 180-182°C |
---|---|
Boiling point | 599.6±60.0 °C(Predicted) |
Density | 1.23±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: ~11 mg/mL at 60 °C |
form | solid |
pka | pKa 6.5 (Uncertain) |
color | white |
CAS DataBase Reference | 83366-66-9(CAS DataBase Reference) |
NCI Dictionary of Cancer Terms | nefazodone; Serzone |
FDA UNII | 59H4FCV1TF |
ATC code | N06AX06 |
NIST Chemistry Reference | Nefazodone(83366-66-9) |
SAFETY
Risk and Safety Statements
Safety Statements | 22-24/25 |
---|---|
WGK Germany | 3 |
Nefazodone price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
American Custom Chemicals Corporation | API0003523 | NEFAZODONE 95.00% | 83366-66-9 | 1G | $800 | 2021-12-16 | Buy |
Medical Isotopes, Inc. | 12475 | NefazodoneHCl | 83366-66-9 | 10mg | $845 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | API0003523 | NEFAZODONE 95.00% | 83366-66-9 | 10G | $4400 | 2021-12-16 | Buy |
Crysdot | CD33000073 | Nefazodone 95+% | 83366-66-9 | 1g | $772 | 2021-12-16 | Buy |
Nefazodone Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Originator
Dutonin,Bristol-Myers Squibb,USA
Uses
A selective serotonin 5-HT2 receptor antagonist. An antidepressant
Definition
ChEBI: Nefazodone is a N-arylpiperazine, a N-alkylpiperazine, a member of triazoles, a member of monochlorobenzenes and an aromatic ether. It has a role as an antidepressant, a serotonergic antagonist, a serotonin uptake inhibitor, an alpha-adrenergic antagonist and an analgesic.
brand name
Serzone (Bristol-Myers Squibb).
Therapeutic Function
Antidepressant
Biological Functions
Although nefazodone (Serzone) is structurally related to trazodone, it is less sedating. It does not block α1- adrenoreceptors, and its use is not associated with priapism. Nefazodone inhibits the neuronal reuptake of serotonin and blocks 5HT2A receptors. Its short half-life requires dosing twice a day. Nefazodone is not associated with weight gain or sexual dysfunction. It inhibits the cytochrome P450 3A4 isoenzyme that is responsible for 50% of known oxidative metabolism, and therefore, nefazodone can elevate levels of drugs dependent on this pathway for metabolism.
Nefazodone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29888 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25363 | 58 |
Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | 1026@dideu.com | China | 8672 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20291 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40068 | 58 |
View Lastest Price from Nefazodone manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2019-07-06 | Nefazodone
83366-66-9
|
US $1.00 / KG | 1G | 98% | 100KG | Career Henan Chemical Co |
- Nefazodone
83366-66-9
- US $1.00 / KG
- 98%
- Career Henan Chemical Co