ChemicalBook >> CAS DataBase List >>N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
- CAS No.
- 302964-08-5
- Chemical Name:
- N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
- Synonyms
- Dasatinib Int N-1;CAY10697;2-((6-ChL;)amino)-N-(2-chL;dasatinib Dichloro;Dasatinib Impurity M;Dasatinib EP Impurity-D;Dasatinib Intermediate 1;Dasatinib Dichloro Impurity;2-(6-Chloro-2-MethylpyriMidin-4-ylaMino)-N-(2-chloro-6-Methyl
- CBNumber:
- CB51473109
- Molecular Formula:
- C16H13Cl2N5OS
- Molecular Weight:
- 394.28
- MDL Number:
- MFCD11045075
- MOL File:
- 302964-08-5.mol
- MSDS File:
- SDS
Last updated:2024-08-21 22:41:43
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Properties
Melting point | 333-335°C |
---|---|
Boiling point | 566.95° C (Predicted) |
Density | 1.516±0.06 g/cm3(Predicted) |
refractive index | n20D 1.72 (Predicted) |
storage temp. | Inert atmosphere,2-8°C |
solubility | DMSO (Slightly) |
pka | 10.92±0.70(Predicted) |
form | Solid |
color | Pale Yellow |
Water Solubility | Slightly soluble in water |
InChI | InChI=1S/C16H13Cl2N5OS/c1-8-4-3-5-10(17)14(8)23-15(24)11-7-19-16(25-11)22-13-6-12(18)20-9(2)21-13/h3-7H,1-2H3,(H,23,24)(H,19,20,21,22) |
InChIKey | LMXUWARKUIELGT-UHFFFAOYSA-N |
SMILES | S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1NC1C=C(Cl)N=C(C)N=1 |
CAS DataBase Reference | 302964-08-5(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
HS Code | 2933399990 | |||||||||
NFPA 704 |
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N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide price More Price(31)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | C3675 | 2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide | 302964-08-5 | 1G | $23 | 2024-03-01 | Buy |
TCI Chemical | C3675 | 2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide | 302964-08-5 | 5G | $65 | 2024-03-01 | Buy |
Cayman Chemical | 17806 | CAY10697 ≥98% | 302964-08-5 | 50mg | $56 | 2024-03-01 | Buy |
Cayman Chemical | 17806 | CAY10697 ≥98% | 302964-08-5 | 100mg | $105 | 2024-03-01 | Buy |
Cayman Chemical | 17806 | CAY10697 ≥98% | 302964-08-5 | 250mg | $241 | 2024-03-01 | Buy |
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Chemical Properties,Uses,Production
Description
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide is a pharmaceutical intermediate compound used as a synthetic intermediate for dasatinib. Dasatinib is a targeted anticancer drug used to treat chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL). It is also a receptor and non-receptor Tyk (tyrosine kinase) inhibitor, which plays an important role in certain cancers and fibrotic diseases.
Chemical Properties
Pale Yellow Solid
Uses
Dasatinib intermediate. A protein tyrosine kinase inhibitor.
![1780-26-3](/CAS/GIF/1780-26-3.gif)
![302964-24-5](/CAS/GIF/302964-24-5.gif)
![302964-08-5](/CAS/GIF/302964-08-5.gif)
Synthesis of N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide from 4,6-Dichloro-2-methylpyrimidine and 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 290)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Yangzhou Qinyuan Pharmatech Co.,ltd | +86-18752526868 | jennysun@yzqyyykj.com | China | 71 | 58 |
Huanfu Industrial Co.,(Shanghai)Ltd. | +86-18001856580 +86-18001856580 | 2415195517@qq.com | China | 43 | 58 |
Hebei Guanlang Biotechnology Co,.LTD | +8619930503252 | daisy@crovellbio.com | China | 5828 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 16914 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21668 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9332 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 | chloewu@chicopharm.cn | CHINA | 341 | 58 |
View Lastest Price from N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-08-22 | N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]
302964-08-5
|
US $0.00 / KG | 1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
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2024-08-21 | Dasatinib Intermediate
302964-08-5
|
US $5.00-2.00 / KG | 1KG | 99% | 10000kg | Hebei Guanlang Biotechnology Co,.LTD | |
![]() |
2024-08-20 | N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
302964-08-5
|
US $1350.00 / Kg/Bag | 1KG | 99% | 100kg | Baoji Guokang Bio-Technology Co., Ltd. |
-
- N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]
302964-08-5
- US $0.00 / KG
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Dasatinib Intermediate
302964-08-5
- US $5.00-2.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co,.LTD
-
- N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
302964-08-5
- US $1350.00 / Kg/Bag
- 99%
- Baoji Guokang Bio-Technology Co., Ltd.
302964-08-5(N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide)Related Search:
2-(6-Chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-
Dasatinib Intermediate 1
2-(6-Chloro-2-MethylpyriMidin-4-ylaMino)-N-(2-chloro-6-Methyl
2-[(6-chloro-2-MethylpyriMidin-4-yl)aMino]-N-(2-chloro-6-Methylphenyl)-1,3-thiazole-5-carboxaMide
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-yrimidinyl)amino]-5-thiazolecarboxamide
N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]
CAY10697
N-(2-Chloro-6-methyl-phenyl)-2-[(6-chloro-2-methyl-pyrimidin-4-yl)amino]thiazole-5-carboxamide
N-(2-CHLORO-6-METHYLPHENYL)-2-[(6-CHLORO-2-METHYL-4-PYRIMIDINYL)AMINO]-5-THIAZOLECARBOXAMIDE
2-[(6-Chloro-2-methyl-4-pyrimidyl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide
Dasatinib Dichloro Impurity
)amino)-N-(2-chL
2-((6-ChL
N- (2-chloro-6-methylphenyl) -2-[(6-chloro-2-methyl-4-pyrimidinyl) amino] -5-thiazole-formamide
Dasatinib Impurity M
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidi...
dasatinib Dichloro
2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide 95%
Dasatinib Int N-1
Dasatinib EP Impurity-D
N - (2-chloro-6-methylphenyl) -2- [(6-chloro-2-methyl-4-pyrimidinyl) amino] -5-thiazolamide
N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)ami]-5-thiazolecarboxamide
2-(6-Chloro-2-methyl-pyrimidin-4-ylamino)-thiazole-5-carboxylic acid (2-chloro-6-methyl-phenyl)-amide
N-(2-Chloro-6-Methylphenyl)-2-[(6-chloro-2-Methyl-4-pyriMidinyl)aMino]-5-thiazolecarboxaMi
302964-08-5
2964-08-5
964-08-5
Dasatinib
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Intermediates & Fine Chemicals
Pharmaceuticals
Sulfur & Selenium Compounds