Methylprednisolone sodium succinate
- CAS No.
- 2375-03-3
- Chemical Name:
- Methylprednisolone sodium succinate
- Synonyms
- METHYLPREDNISOLONE SODIUM SUCCINATE;6α-methylprednisolone 21-hemisuccinate sodium salt;1,4-PREGNADIEN-6-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-SUCCINATE, SODIUM SALT;6ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE 21-HEMISUCCINATE SODIUM SALT;(6alpha,11beta)-21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-6-methyl-pregna-1,4-diene-3,20-dione monosodium salt;u9088;Metypred;NSC 48989;succinate);solu-medrol
- CBNumber:
- CB5163715
- Molecular Formula:
- C26H33O8.Na
- Molecular Weight:
- 496.53
- MDL Number:
- MFCD00152612
- MOL File:
- 2375-03-3.mol
- MSDS File:
- SDS
| Melting point | >186°C (dec.) |
|---|---|
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | lyophilized powder |
| color | White to Off-White |
| InChIKey | FQISKWAFAHGMGT-JXAFMBTDNA-M |
| SMILES | [C@]12(C[C@@H](C3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@H](C[C@]1(C)[C@@](CC[C@@]21[H])(O)C(=O)COC(=O)CCC([O-])=O)O)C)[H].[Na+] |&1:0,2,9,11,13,15,17,20,r| |
| CAS DataBase Reference | 2375-03-3(CAS DataBase Reference) |
| FDA UNII | LEC9GKY20K |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H351-H360 | |||||||||
| Precautionary statements | P201-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 61-40 | |||||||||
| Safety Statements | 53-22-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TU4154060 | |||||||||
| Toxicity | LD50 oral in rat: > 5gm/kg | |||||||||
| NFPA 704 |
|
Methylprednisolone sodium succinate price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M3781 | 6α-Methylprednisolone 21-hemisuccinate sodium salt lyophilized powder | 2375-03-3 | 25MG | $78.7 | 2023-06-20 | Buy |
| Sigma-Aldrich | M3781 | 6α-Methylprednisolone 21-hemisuccinate sodium salt lyophilized powder | 2375-03-3 | 250MG | $411 | 2023-06-20 | Buy |
| Sigma-Aldrich | M3781 | 6α-Methylprednisolone 21-hemisuccinate sodium salt lyophilized powder | 2375-03-3 | 1G | $1300 | 2023-06-20 | Buy |
| Usbiological | 220287 | Succinate | 2375-03-3 | 100Tests | $1048 | 2021-12-16 | Buy |
| TRC | M326725 | 6α-Methylprednisolone21-HemisuccinateSodiumSalt | 2375-03-3 | 100mg | $140 | 2021-12-16 | Buy |
Methylprednisolone sodium succinate Chemical Properties,Uses,Production
Description
Methylprednisolone Sodium Succinate is the sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. It is converted into active prednisolone in the body, which activates glucocorticoid receptor-mediated gene expression. This includes inducing the synthesis of the anti-inflammatory protein IkappaB-alpha and inhibiting the synthesis of nuclear factor kappa B (NF-kappaB). As a result, proinflammatory cytokine production, such as IL-1, IL-2, and IL-6, is down-regulated, and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved.
Uses
6α-Methylprednisolone 21-Hemisuccinate is a glucocorticosteroid used in anti-inflammatory medication in the treatment of spinal cord injuries.
Uses
6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.
Definition
ChEBI: Methylprednisolone sodium succinate is a corticosteroid hormone.
brand name
A-Methapred (Abbott); A-Methapred (Hospira); Solu-Medrol (Pharmacia & Upjohn).
Biochem/physiol Actions
Glucocorticoid with slightly longer half-life than that of prednisolone.
Side effects
Methylprednisolone Sodium Succinate is commonly given by injection and common side effects include: injection site pain/redness/swelling, nausea, vomiting, heartburn, headache, dizziness, difficulty sleeping, appetite changes, increased sweating, acne, increased blood sugar, sore throat, fever, chills, cough, white spots in the mouth. Serious side effects manifest as abnormal weight gain, menstrual disorders, bone/joint pain, easy bruising/bleeding, mental/mood changes, fast/slow/irregular heartbeat, stomach/intestinal bleeding symptoms, seizures, liver problems, and symptoms of severe allergic reactions. Contact your doctor if any of these serious adverse symptoms occur.
Methylprednisolone sodium succinate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8618959220845 | sales@amoychem.com | China | 6383 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34553 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15354 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8617732866630 | bess@weibangbio.com | China | 18154 | 58 |
View Lastest Price from Methylprednisolone sodium succinate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | 6α-Methylprednisolone 21-hemisuccinate sodium salt
2375-03-3
|
US $39.00-122.00 / mg | 98.69% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-19 | 6α-Methylprednisolone 21-hemisuccinate sodium salt
2375-03-3
|
US $39.00-122.00 / mg | 98.69% | 10g | TargetMol Chemicals Inc. |
-
- 6α-Methylprednisolone 21-hemisuccinate sodium salt
2375-03-3
- US $39.00-122.00 / mg
- 98.69%
- TargetMol Chemicals Inc.
-
- 6α-Methylprednisolone 21-hemisuccinate sodium salt
2375-03-3
- US $39.00-122.00 / mg
- 98.69%
- TargetMol Chemicals Inc.
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