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(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Structure
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol structure
CAS No.
112068-01-6
Chemical Name:
(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol
Synonyms
(S)-DIPHENYL(PYRROLIDIN-2-YL)METHANOL;(S)-DIPHENYLPROLINOL;SDPP;(S)-(-)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL;ALPHA,ALPHA-DIPHENYL-L-PROLINOL;Diphenyl(2-pyrrolidinyl)methanol;(S)-(-)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE;alpha,alpha-Diphenyl;Nebivolol Impurity 49;Dextrodiphenylprolinol
CBNumber:
CB5178203
Molecular Formula:
C17H19NO
Molecular Weight:
253.34
MDL Number:
MFCD00075506
MOL File:
112068-01-6.mol
MSDS File:
SDS
Last updated:2024-10-29 11:48:30
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(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Properties

Melting point 77-80 °C(lit.)
alpha -59 º (c=3, methanol 25 ºC)
Boiling point 396.54°C (rough estimate)
Density 1.0078 (rough estimate)
refractive index -66.5 ° (C=3, CHCl3)
storage temp. Inert atmosphere,Room Temperature
solubility Soluble in chloroform.
form powder
pka 13.15±0.29(Predicted)
color white to off white ., crystal
optical activity [α]20/D 67°, c = 3 in chloroform
Merck 14,155
BRN 17103
InChIKey OGCGXUGBDJGFFY-INIZCTEOSA-N
CAS DataBase Reference 112068-01-6(CAS DataBase Reference)
FDA UNII K3HE3KC32M
NIST Chemistry Reference S-(-)-1,1-diphenylprolinol(112068-01-6)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39-24/25-36
WGK Germany  3
F  10-34
TSCA  No
HS Code  29339900
NFPA 704
1
2 0

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol price More Price(38)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 368199 (S)-(?)-α,α-Diphenyl-2-pyrrolidinemethanol 99% 112068-01-6 1g $15.6 2024-03-01 Buy
Sigma-Aldrich 368199 (S)-(?)-α,α-Diphenyl-2-pyrrolidinemethanol 99% 112068-01-6 5g $90.5 2024-03-01 Buy
TCI Chemical D2735 (S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol >98.0%(GC)(T) 112068-01-6 1g $52 2024-03-01 Buy
TCI Chemical D2735 (S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidinemethanol >98.0%(GC)(T) 112068-01-6 5g $248 2024-03-01 Buy
Alfa Aesar L09217 (S)-(-)-alpha,alpha-Diphenylprolinol 98% 112068-01-6 1g $82 2023-06-20 Buy
Product number Packaging Price Buy
368199 1g $15.6 Buy
368199 5g $90.5 Buy
D2735 1g $52 Buy
D2735 5g $248 Buy
L09217 1g $82 Buy

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Chemical Properties,Uses,Production

Chemical Properties

white to beige crystals or crystalline powder

Uses

suzuki reaction

Uses

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol is used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.

Preparation

Into a four-necked flask, add tetrahydrofuran, L-proline methyl ester hydrochloride, and phenyl magnesium chloride （dissolved in tetrahydrofuran) solution was added dropwise from a constant pressure dropping funnel, and the addition was completed in about 4 hours, and then stirred at 10-15°C for 3 hours. Add water, adjust the pH to 5-6 with 10% ammonium chloride aqueous solution, extract with dichloromethane, extract the aqueous layer twice with dichloromethane each time, and obtain the organic phase. Wash once with saturated sodium chloride aqueous solution. The organic phase was dried with anhydrous sodium sulfate for 4 hours and filtered. The obtained organic phase was distilled under reduced pressure to distill dichloromethane and tetrahydrofuran to obtain light yellow oily (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol, yield 86.6%.
(S)-( )-α,α-Diphenyl-2-pyrrolidinemethanol

Application

(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol (DPPM) may be used in the following processes:

  • DPPM reacts with catecholborane to form a spiroborate ester, which can be an efficient catalyst for the synthesis of enantiopure alcohols by borane reduction of acetophenone.
  • The catalyst generated in situ by reacting DPPM with borane-diethylaniline, can efficiently catalyze the enantioselective reduction of 2′-fluoroacetophenone.
  • Mesoporous SBA-15 silica functionalized with DPPM can catalyze the addition of diethylzinc to benzaldehyde to form (S)-1-phenyl-propanol.
Used to prepare the corresponding oxazaborolidines for the borane-mediated asymmetric reduction of ketones.

General Description

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol is a bifunctional organocatalyst.

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Preparation Products And Raw materials

Raw materials

PHENYLMAGNESIUM BROMIDE Ethyl formate L-Proline Tetrahydrofuran

Preparation Products

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Suppliers

Global( 518)Suppliers
Supplier Tel Email Country ProdList Advantage
China Synchem Technology Co.,Ltd. 		+86-0552-4929304 +86-18055277008 wangxuhui1985@126.com China 57 55
Hebei Weibang Biotechnology Co., Ltd 		+8617732866630 bess@weibangbio.com China 18154 58
Springchem New Material Technology Co.,Limited 		+86-021-62885108 +8613917661608 info@spring-chem.com China 2068 57
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 18779 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Hangzhou FandaChem Co.,Ltd. 		+8615858145714 FandaChem@Gmail.com China 9214 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29884 58
Shanghai Arbor Chemical Co., Ltd. 		021-60451682 act@arborchemical.com CHINA 904 58
Supplier Advantage
China Synchem Technology Co.,Ltd. 		55
Hebei Weibang Biotechnology Co., Ltd 		58
Springchem New Material Technology Co.,Limited 		57
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
Hangzhou FandaChem Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shanghai Arbor Chemical Co., Ltd. 		58

Related articles

View Lastest Price from (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol pictures 2024-10-29 (S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol
112068-01-6
 US $0.00 / KG 1KG 99% 500000kg Hebei Weibang Biotechnology Co., Ltd
Dapoxetine Impurity 72 pictures 2024-09-20 Dapoxetine Impurity 72
112068-01-6
 US $0.00-0.00 / mg 10mg 0.98 10g ShenZhen H&D Pharmaceutical Technology Co., LTD
(S)-(-)-Diphenyl-2-Pyrrolidinemethanol pictures 2023-01-31 (S)-(-)-Diphenyl-2-Pyrrolidinemethanol
112068-01-6
 US $100.00 / kg 25kg 99.99% 200ton Hebei Mojin Biotechnology Co., Ltd

(S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol Spectrum

(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol(112068-01-6)1HNMR(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol(112068-01-6)Raman(S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol(112068-01-6)IR

112068-01-6((S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol)Related Search:

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A,A-DIPHENYL-L-PROLINOL (s)-(-)-à,à-diphenyl-2-pyrrolidinemethanol (s)-(-)-à,à-diphenylprolinol α,α-diphenyl-l-prolinol 2,2-DIPHENYL-(2S)-2-PYRROLIDINEMETHANOL (S)-(-)-alpha,alpha-diphenyl-2-pyrrolidine (S)-(-)-ALPHA ALPHA-DIPHENYL-2- PYRROLIDINEMETHANOL 99% 2-PYRROLIDINEMETHANOL, .ALPHA.,.ALPHA.-DIPHENYL-, (2S)- (S)-(-)-2-(Diphenylhydroxymethyl)pyrrolidine alpha,alpha-Diphenyl-L-prolinol (S)-Alpha,alpha-diphenyl-l-prolinol (S)-(-)-alpha,alpha-Diphenyl-2-pyrrolidineMethanol, 99+% 1GR (S)-()-α,α-Diphenyl-2-pyrrolidineMethanol 99% (S)-(-)-alpha,alpha-Diphenyl-2-rrolidine Methanol (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol (S)-()-α,α-Diphenyl-2-pyrrolidinemethanol, >=99% (S)-1,1-Diphenylprolinol (S)-α,α-Diphenyl-2-pyrrolidinemethanol,99%e.e. (S)-(-)-α,α-Diphenylprolinol for synthesis 2-Pyrrolidinemethanol, α,α-diphenyl-, (2S)- (S)-(-)-ɑ,ɑ-Diphenylprolinol, 98% (S)-2-(Hydroxydiphenylmethyl)pyrrolidine alpha,alpha-diphenyl-L-proline (S)-α,α-Diphenyl-2-pyrrolidinemethanol, (S)-2-(Diphenylhydroxymethyl)pyrrolidine (S)-(-)-2-(Diphenylhydroxymethyl)pyrrolidine, α,α-Diphenyl-L-prolinol (S)-(-)-Alpha,alpha-diphenyl-2-pyrrolidin emethanol, 99+% (2S)-α,α-Diphenyl-2-pyrrolidinemethanol (2S)-α,α-Diphenyl-2α-pyrrolidinemethanol (2S)-α,α-Diphenylpyrrolidine-2α-methanol [(2S)-Pyrrolidine-2-yl]diphenylmethanol Diphenyl[(2S)-2-pyrrolidinyl]methanol (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol ,98% (S)-()-α,α-Diphenyl-2-pyrrolidinemethanol,(S)-()-2-(Diphenylhydroxymethyl)pyrrolidine, α,α-Diphenyl-L-prolinol alpha,alpha-Diphenyl (S)-|á,|á-Diphenyl-2-pyrrolidinemethanol (S)-(-)-alpha,alpha-alpha,alpha-diphenyl-2-pyrrolidine methanol (a,a-Diphenyl-L-prolinol) (S)-A,A-DIPHENYL-2-PYRROLIDINE METHANOL (S)-(-)-A,A-DIPHENYLPROLINOL (S)-1-DIPHENYL-PROLINOL (S)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE (S)-(-)-ALPHA,ALPHA-DIPHENYLPROLINOL (S)-ALPHA,ALPHA-DIPHENYL-2-PYRROLIDINEMETHANOL (S)-(-)-DIPHENYL-2-PYRROLIDINEMETHANOL (S)-(-)-DIPHENYLPYRROLIDINEMETHANOL DIPHENYL-L-PYRROLIDIN-2-YL-METHANOL 2-PYRROLIDINEMETHANOL, A,A-DIPHENYL-, (2S)- (-)-ALPHA,ALPHA-DIPHENYL-L-PROLINOL (S)-(-)-ALPHA, ALPHA-DIPHENYI-2-PYRROLIDINE METHANOL (S)-(-)-α,α-Diphenyl-2-pyrrolidinemethanol> (S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol (S)-(-)- α,α-Diphenylprolinol (S)-(+)-α,α-Diphenyl-2-pyrrolidinemethanol USP/EP/BP (S)-(-)-2-(Diphenylhydroxymethyl)pyrrolidine alpha,alpha-Diphenyl-L- Dextrodiphenylprolinol Nebivolol Impurity 49 TIANFU-CHEM CAS:112068-01-6 alpha,alpha-Diphenyl-L-prolinol (S)-DIPHENYL(PYRROLIDIN-2-YL)METHANOL Diphenyl(2-pyrrolidinyl)methanol (S)-(-)-2-(DIPHENYLHYDROXYMETHYL)PYRROLIDINE