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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Structure
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate structure
CAS No.
141942-85-0
Chemical Name:
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Synonyms
ATS-5;ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE;RETINCIC ACID;Ethyl (R)-(-)-4-cyan;(R)-Ethyl 4-cyano-3-;Ats-5(For Atorvastatin);Atorvastatin Impurity 127;Atorvastatin Impurity 166;)-4-cyano-3-hydroxybutyrate;(R)-4-cyano-3-hydroxybutyric
CBNumber:
CB5188978
Molecular Formula:
C7H11NO3
Molecular Weight:
157.17
MDL Number:
MFCD00270839
MOL File:
141942-85-0.mol
MSDS File:
SDS
Last updated:2025-01-27 09:38:02
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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Properties

alpha -5 º (neat)
Boiling point 270 °C(lit.)
Density 1.114 g/mL at 25 °C(lit.)
refractive index n20/D 1.448(lit.)
Flash point >230 °F
storage temp. 2-8°C
solubility Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
form Liquid
pka 13.03±0.20(Predicted)
color Colorless to yellow
Specific Gravity 1.114
optical activity [α]25/D 5°, neat
BRN 5328715
InChIKey LOQFROBMBSKWQY-ZCFIWIBFSA-N
CAS DataBase Reference 141942-85-0(CAS DataBase Reference)
UNSPSC Code 12352108
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319
Precautionary statements  P264-P280-P305+P351+P338-P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  1
HS Code  29269090
NFPA 704
0
2 0

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 479772 Ethyl (R)-(?)-4-cyano-3-hydroxybutyrate 95% 141942-85-0 5g $87.2 2023-06-20 Buy
TCI Chemical C1474 Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate >97.0%(GC) 141942-85-0 1g $16 2024-03-01 Buy
TCI Chemical C1474 Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate >97.0%(GC) 141942-85-0 5g $35 2024-03-01 Buy
Alfa Aesar L19771 Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98% 141942-85-0 5g $43.65 2024-03-01 Buy
Alfa Aesar L19771 Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98% 141942-85-0 25g $137.65 2024-03-01 Buy
Product number Packaging Price Buy
479772 5g $87.2 Buy
C1474 1g $16 Buy
C1474 5g $35 Buy
L19771 5g $43.65 Buy
L19771 25g $137.65 Buy

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemical Properties,Uses,Production

Chemical Properties

yellow liquid

Uses

(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester is used in a biocatalytic process for the synthesis of an atorvastatin intermediate and degredation products/impurities.

Uses

analgesic, antipyretic, and anti-inflammatory

Application

Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease.
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate synthesis

638-07-3
143-33-9
141942-85-0
Synthesis of Ethyl (R)-(-)-4-cyano-3-hydroxybutyate from Ethyl 4-chloroacetoacetate and Sodium cyanide

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Preparation Products And Raw materials

Raw materials

Butanoic acid, 4-cyano-3-hydroxy-, (3R)- Ethyl 4-bromo-3-hydroxybutyrate Sodium cyanide Ethanol Ethyl 4-chloroacetoacetate

Preparation Products

(3R,5R)-6-Cyano-3,5-dihydroxy-hexanoic Acid tert-Butyl Ester

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Suppliers

Global( 428)Suppliers
Supplier Tel Email Country ProdList Advantage
Jiangxi Sunway Chemical Co., Ltd.
+86-0794-5259909 +8615888611133 dave@jxswchem.com China 22 58
Jiangxi Sunway Chemical Co., Ltd.
+86-0794-5259909 +8615888611133 dave@jxswchem.com China 22 58
Hebei Mujin Biotechnology Co.,Ltd 		+86 13288715578 +8613288715578 sales@hbmojin.com China 12827 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5887 58
Hebei Dangtong Import and export Co LTD 		+86-86-4001020630 +8619831957301 admin@hbdangtong.com China 1000 58
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410 sales@ichemie.com China 1014 58
hebei hongtan Biotechnology Co., Ltd 		+86-86-1913198-3935 +8617331935328 sales03@chemcn.cn China 970 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29792 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886 info@dakenam.com China 19914 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21632 55
Supplier Advantage
Jiangxi Sunway Chemical Co., Ltd.
58
Jiangxi Sunway Chemical Co., Ltd.
58
Hebei Mujin Biotechnology Co.,Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Dangtong Import and export Co LTD 		58
Hangzhou ICH Biofarm Co., Ltd 		58
hebei hongtan Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55

Related articles

View Lastest Price from Ethyl (R)-(-)-4-cyano-3-hydroxybutyate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate pictures 2025-02-18 Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
141942-85-0
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate pictures 2025-02-18 Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
141942-85-0
 US $0.00 / KG 1KG 99% 50000KG/month Hebei Mujin Biotechnology Co.,Ltd
Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate pictures 2025-02-18 Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate
141942-85-0
 US $5.00 / kg 1kg ≥98% 200mt/year Jinan Finer Chemical Co., Ltd

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(R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER (R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER (R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE (R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE (S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL ETHYL (3R)-4-CYANO-3-HYDROXY-BUTANOATE ETHYL (R)-4-CYANO-3-HYDROXYBUTANOATE ETHYL-(R)-(+)-4-CYANO-3-HYDROXYBUTANOATE Ethyl (R)-(-)-4-cyano-3-hydroxybutyate ETHYL (R)-(-)-4-CYANO-3-HYDROXYBUTYRATE ETHYL (R)-4-CYANO-3-HYDROXYBUTYRATE BUTANOIC ACID, 4-CYANO-3-HYDROXY-, ETHYL ESTER, (R) BUTANOIC ACID 4-CYANO-3-HYDROXY-ETHYL ESTER, (S) thyl (R)-(-)-4-Cyano-3-Hydroxy Butyate (3R)-4-cyano-3-hydroxybutyric acid ethyl ester FEthyl (R)-(-)-4-cyano-3-hydroxybutyrate Atorvastatin interMediates Ats-5 (R)-4-cyano-3-hydrobutyric acid ethyl ester Butanoic acid, 4-cyano-3-hydroxy-, ethyl ester, (3R)- (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester ethyle(R)-4-cyano-3-hydroxybutanoate (R)-4-Cyano-3-hydroxy butanoate (R)-4-cyano-3-hydroxybutyric R(-)-4-cyano-3-hydroxybutyrtc ethyl ester ATS-5:(R)ETHYL-4-CYANO-3-HYCLROXY BUTANCATE R(-)4-CYANO-3-HYDROXYBUTYRIC ETHYL ESTER R(-)-4-CYANO-3-HYDROXYBUTYRTC ETHYL ESTER /ATS-5 R(-)-4-Cyano-3-hydroxubutyricethylester (R)-4-Cyano-3-hydroxybuttersureethylester (R)-4-cyano-3-hydrobutyric acid ethyl ester (R)-4-CYANO-3-HYDROXYBUTANOATE ETHYL RETINCIC ACID [R]-[-]-Ethyl-cyano-3-hydroxybutyrate (R)-(-)-4-Cyano-3-hydroxybutyratic acid, ethyl ester Ethyl (R)-4-cyano-3-hydroxybutanoate,99% Ethyl (R)-4-cyano-3-hydroxybutanoate,95% Atorvastatincalcium(R)-4-cyano-3-hydrobutyric Acid Ethyl Ester Ethyl (R)-(-)-4-cyan 4-Cyano-3-hydroxy-butyric acid ethyl ester )-4-cyano-3-hydroxybutyrate Ethyl-(R)-4-(-)-cyano-3-hydroxybutyrate(C-1) (R)-Ethyl 4-cyano-3- Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0] Ats-5(For Atorvastatin) Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate > (R)-(-)-4-Cyano-3-hydroxybutyrate Atorvastatin Impurity 127 (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl (R)-(-)-4-CYANO-3-HYDROXYBUTYATE (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl EsterQ: What is (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the CAS Number of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the storage condition of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE ATS-5 Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate(ATS-5) Atorvastatin calcium impurity 63 ethyl (R)-3-hydroxy-4-cyano-butyrate Atorvastatin Impurity 166 141942-85-0 41942-85-0 NCCH2CHOHCH2CO2C2H5